Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway
RIBEYE(B)-domain binds to lipid components of synaptic vesicles in an NAD(H)-dependent, redox-sensitive manner
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element
Structure of O-acetylserine sulfhydrylase (OASS) from Brucella abortus compared with all known OASS structures. The high degree of variation is observed in N-terminal domain, which determined the size of active site cleft and responsible for interactions with Serine acetyl Transferase. The co-factor Pyridoxal phosphate (PLP) is shown in ball & stick model in the active site. For more information, please see study by Dharavath et al. in this issue, pages 1221–1239. Image provided by Samudrala Gourinath.