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May 2018
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Cover Image
Cover Image
A high-resolution crystal structure of the molybdenum insertase Cnx1E from Arabidopsis thaliana reveals two mutually exclusive molybdate binding sites, that have mechanistic implications for the Mo-insertion process into the pterin moiety of the molybdenum cofactor. In this issue of the Biochemical Journal, Kruse et al. found that molybdate is sequentially bound to the entry and the catalytically-productive site, going hand in hand with a distinct backbone conformation shift. In this image, adenylated molybdopterin and the two molybdate ions are shown in front of the Cnx1E active site. (Image provided by J. Krausze, W. A. Sassen and T. Kruse); for details see pages 1739–1753.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
Review Articles
Commentaries
Research Articles
MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis
Biochem J (2018) 475 (10): 1687–1699.
TFE-induced local unfolding and fibrillation of SOD1: bridging the experiment and simulation studies
Biochem J (2018) 475 (10): 1701–1719.
The functional principle of eukaryotic molybdenum insertases
Joern Krausze; Thomas W. Hercher; Dagmar Zwerschke; Martin L. Kirk; Wulf Blankenfeldt; Ralf R. Mendel; Tobias Kruse
Biochem J (2018) 475 (10): 1739–1753.
Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways
Leena Rauhala; Tiina Jokela; Riikka Kärnä; Geneviève Bart; Piia Takabe; Sanna Oikari; Markku I. Tammi; Sanna Pasonen-Seppänen; Raija H. Tammi
Biochem J (2018) 475 (10): 1755–1772.
Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Biochem J (2018) 475 (10): 1773–1788.
Deregulation of LIMD1–VHL–HIF-1α–VEGF pathway is associated with different stages of cervical cancer
Chandraditya Chakraborty; Sraboni Mitra; Anirban Roychowdhury; Sudip Samadder; Sankhadeep Dutta; Anup Roy; Pradip Das; Ranajit Kumar Mandal; Tyson V. Sharp; Susanta Roychoudhury; Chinmay Kumar Panda
Biochem J (2018) 475 (10): 1793–1806.
Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes
Biochem J (2018) 475 (10): 1807–1820.
An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
Meng Yuan; Iain W. McNae; Yiyuan Chen; Elizabeth A. Blackburn; Martin A. Wear; Paul A.M. Michels; Linda A. Fothergill-Gilmore; Ted Hupp; Malcolm D. Walkinshaw
Biochem J (2018) 475 (10): 1821–1837.
ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity
Ioannis Dafnis; Christina Raftopoulou; Christina Mountaki; Evgenia Megalou; Vassilis I. Zannis; Angeliki Chroni
Biochem J (2018) 475 (10): 1839–1859.