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Issues

ISSN 0264-6021
EISSN 1470-8728
In this Issue

Review Articles

Biochemical Journal (16 August 2018) 475 (15): 2491–2509.
Biochemical Journal (16 August 2018) 475 (15): 2511–2545.

Research Articles

Biochemical Journal (16 August 2018) 475 (15): 2417–2433.
Biochemical Journal (16 August 2018) 475 (15): 2435–2455.
Biochemical Journal (16 August 2018) 475 (15): 2457–2471.
Biochemical Journal (16 August 2018) 475 (15): 2473–2489.
Biochemical Journal (16 August 2018) 475 (15): 2547–2557.
Biochemical Journal (16 August 2018) 475 (15): 2559–2576.
  • Cover Image

    Cover Image

    issue cover

    Cartoon illustration of the simultaneous binding of PAP (a competitive inhibitor of the physiological enzyme co-factor adeonosine 3′-phosphate 5′-phosphosulfate, PAPS) and a heptapeptide saccharide substrate (sticks), poised for sulfation (dashed line) in the active site of heparan sulfate 2-O-sulfotransferase (PDB ID: 4NDZ). The PAP(S)-binding site and the oligosaccharide-binding sites provide dual opportunities for the screening, identification and rational design of small molecule inhibitors of this enzyme, which include the highly sulfated polyanionic drug suramin and the promiscuous protein kinase inhibitor rottlerin. Rottlerin competes with the PAPS co-factor in sulfotransferases, opening the door for the discovery and optimisation of other kinase inhibitors that inhibit these classes of enzyme, including protein tyrosine sulfotransferases (TPSTs). For further details, see the article by Byrne et al. in this issue (pages 2417–2433) and its companion article on pages 2435–2455. Image kindly provided by Neil Berry and Patrick Eyers.

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