Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate
Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate
Role of cysteine 416 in N-ethylmaleimide sensitivity of human equilibrative nucleoside transporter 1 (hENT1)
In this issue of the Biochemical Journal, Müller et al. report on the role of inorganic polyphosphate (polyP) and ATP during the initial state of microvascularization. The research shows that exposure of endothelial cells to energy-rich polyP accelerates an autocrine mechanism involved in cell migration via induction of ATP production both extracellularly and intracellularly. For details, see pages 3255–3273. The cover image shows the journey of polyP from its release by platelets to the formation of extracellular ATP and the induction of intracellular ATP production via glycolysis close to the cell membrane, resulting in the generation of an ATP gradient that enables chemotaxis to occur. The image was kindly provided by Werner E.G. Müller and Xiaohong Wang.