G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants
Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation
Variants with increased negative electrostatic potential in the Cx50 gap junction pore increased unitary channel conductance and magnesium modulation
Structure-function studies of the asparaginyl-tRNA synthetase from Fasciola gigantica: understanding the role of catalytic and non-catalytic domains
Multiphasic effect of vinyl pyrrolidone polymers on amyloidogenesis, from macromolecular crowding to inhibition
The cover image shows an artistic representation of the fluorescence-based assay of deadenylase activity used by Pavanello et al. in this issue, with fluorescence proportional to enzyme activity. Fluorescence (λem = 528 nm) was detected in a multi-mode reader using 96-well plates. Activity of different enzyme complexes (left to right) was measured at various time points (top to bottom). Controls (inactive enzyme preparations and no enzyme controls) were also included (bottom two rows). Pavanello et al. report that the central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4–Not nuclease module (see pages 3437–3450).