The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated
The laterally acquired GH5 ZgEngAGH5_4 from the marine bacterium Zobellia galactanivorans is dedicated to hemicellulose hydrolysis
In this issue Moreira and colleagues provide insights into leptin signaling and male reproductive health and ask if leptin signaling is the missing link between obesity and subfertility. The cover image shows a representation of leptin signaling pathways. Circulating leptin bounds to the long isoform of leptin receptor (LepRb), which activates JAK2 tyrosine kinase, triggering a cascade of downstream signaling pathways. For further details, see pages 3535–3560.