Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies
Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity
Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells
New tools for an old question: dependence of ATP and bicarbonate for branched-chain keto acids oxidation
The spatial configuration of chromatin is fundamental to ensure any given cell can fulfil its functional duties. In this issue MacGregor and colleagues (pages 2141–2156) discuss the similarities and differences of large-scale chromatin architecture, as well as the mechanisms which underlie them. The cover image shows FISH analysis of two distinct loci in an adult mouse seminiferous tubule section. White: DAPI, Green and Red: FISH probe signal. Image courtesy of Isobel MacGregor.