Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release
Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP
In this issue Felisberto-Rodrigues (2521–2543) report the biochemical characterisation of full-length human DHX8 and the catalytically active helicase core DHX8Δ547. This study provides an in-depth understanding of the activity of DHX8 and contributes insights into the RNA-unwinding mechanisms of the DEAH-box helicase family. The cover image shows the surface representation of the DHX8 RNA-binding channel with poly(A)6 RNA shown in grey. Cover image provided by Rob L. M. van Montfort.