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Volume 476, Issue 2

January 2019

All Issues

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review Articles
Research Articles

Review Articles

Progress in targeting RAS with small molecule drugs

Frank McCormick

Biochem J (2019) 476 (2): 365–374.

Abstract

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Research Articles

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

Peter M. Fernandes; James Kinkead; Iain W. McNae; Frédéric Bringaud; Paul A.M. Michels; Malcolm D. Walkinshaw

Biochem J (2019) 476 (2): 179–191.

Abstract

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Ca²⁺-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Malene Brohus; Mads T. Søndergaard; Sui Rong Wayne Chen; Filip van Petegem; Michael T. Overgaard

Biochem J (2019) 476 (2): 193–209.

Abstract

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Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides

Tianrong Hang; Wanbiao Chen; Minhao Wu; Li Zhan; Chengliang Wang; Nan Jia; Xuan Zhang; Jianye Zang

Biochem J (2019) 476 (2): 211–223.

Abstract

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Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

Cindy C. Shu; Susan M. Smith; Christopher B. Little; James Melrose

Biochem J (2019) 476 (2): 225–243.

Abstract

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Repurposing of idebenone as a potential anti-cancer agent

Elisabetta Damiani; Raif Yuecel; Heather M. Wallace

Biochem J (2019) 476 (2): 245–259.

Abstract

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Validation of anti-glucocerebrosidase antibodies for western blot analysis on protein lysates of murine and human cells

Wenduo Qi; Brad A. Davidson; Matthew Nguyen; Taylor Lindstrom; Richard J. Grey; Robert Burnett; Elma Aflaki; Ellen Sidransky; Wendy Westbroek

Biochem J (2019) 476 (2): 261–274.

Abstract

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Adaptation of the Staphylococcus aureus leukocidin LukGH for the rabbit host by protein engineering

Nikolina Trstenjak; Lukas Stulik; Harald Rouha; Jakub Zmajkovic; Manuel Zerbs; Eszter Nagy; Adriana Badarau

Biochem J (2019) 476 (2): 275–292.

Abstract

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Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number

Caroline S. Binda; Yasuko Nakamura; Jeremy M. Henley; Kevin A. Wilkinson

Biochem J (2019) 476 (2): 293–306.

Abstract

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The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry

Tiila-Riikka Kiema; Chandan J. Thapa; Mikko Laitaoja; Werner Schmitz; Mirko M. Maksimainen; Toshiyuki Fukao; Juha Rouvinen; Janne Jänis; Rik K. Wierenga

Biochem J (2019) 476 (2): 307–332.

Abstract

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The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally

Lisa Schmidtke; Katharina Schrick; Sabrina Saurin; Rudolf Käfer; Fabian Gather; Julia Weinmann-Menke; Hartmut Kleinert; Andrea Pautz

Biochem J (2019) 476 (2): 333–352.

Abstract

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Phosphofructokinase controls the acetaldehyde-induced phase shift in isolated yeast glycolytic oscillators

David D. van Niekerk; Anna-Karin Gustavsson; Martin Mojica-Benavides; Caroline B. Adiels; Mattias Goksör; Jacky L. Snoep

Biochem J (2019) 476 (2): 353–363.

Abstract

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Double trouble? Gag in conjunction with double insert in HIV protease contributes to reduced DRV susceptibility

Alison Williams; Adriaan Basson; Ikechukwu Achilonu; Heini W. Dirr; Lynn Morris; Yasien Sayed

Biochem J (2019) 476 (2): 375–384.

Abstract

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ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα

Feng-Juan Yan; Yong-Jian Wang; Shi-Ran Yan; Jun Lu; Yuan-Lin Zheng

Biochem J (2019) 476 (2): 385–404.

Abstract

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Silencing of type II phosphatidylinositol 4-kinase β stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells

Sonica Chaudhry; Vibhor Joshi; Naveen Bojjireddy; Maikho Thoh; Santosh K. Sandur; Gosukonda Subrahmanyam

Biochem J (2019) 476 (2): 405–419.

Abstract

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Solution structure of TbTFIIS2-2 PWWP domain from Trypanosoma brucei and its binding to H4K17me3 and H3K32me3

Rui Wang; Jie Gao; Jiahai Zhang; Xuecheng Zhang; Chao Xu; Shanhui Liao; Xiaoming Tu

Biochem J (2019) 476 (2): 421–431.

Abstract

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Review Articles

Progress in targeting RAS with small molecule drugs

Research Articles

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

Ca²⁺-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

Repurposing of idebenone as a potential anti-cancer agent

Validation of anti-glucocerebrosidase antibodies for western blot analysis on protein lysates of murine and human cells

Adaptation of the Staphylococcus aureus leukocidin LukGH for the rabbit host by protein engineering

Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry

The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally

Phosphofructokinase controls the acetaldehyde-induced phase shift in isolated yeast glycolytic oscillators

Double trouble? Gag in conjunction with double insert in HIV protease contributes to reduced DRV susceptibility

ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα

Silencing of type II phosphatidylinositol 4-kinase β stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells

Solution structure of TbTFIIS2-2 PWWP domain from Trypanosoma brucei and its binding to H4K17me3 and H3K32me3

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