The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2: a phosphatidylserine flippase
Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes
Structure of SPH (self-incompatibility protein homologue) proteins: a widespread family of small, highly stable, secreted proteins
Aminoglycoside antibiotic resistance conferred by Hpa2 of MDR Acinetobacter baumannii: an unusual adaptation of a common histone acetyltransferase
Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity
ULK1 is a kinase that has role in autophagy initiation and has been targeted for inhibition as a potential cancer therapy. In this issue Chaikuad and colleagues (875–887) demonstrate the structure of ULK2 is surprisingly similar. The cover image shows the superimposition of ULK1/2-inhibitor complexes demonstrating highly similar binding sites in both ULK kinases.