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Issues
March 2019
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Cover Image
Cover Image
ULK1 is a kinase that has role in autophagy initiation and has been targeted for inhibition as a potential cancer therapy. In this issue Chaikuad and colleagues (875–887) demonstrate the structure of ULK2 is surprisingly similar. The cover image shows the superimposition of ULK1/2-inhibitor complexes demonstrating highly similar binding sites in both ULK kinases.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2: a phosphatidylserine flippase
Lisa Theorin; Kristina Faxén; Danny Mollerup Sørensen; Rebekka Migotti; Gunnar Dittmar; Jürgen Schiller; David L. Daleke; Michael Palmgren; Rosa Laura López-Marqués; Thomas Günther Pomorski
Biochem J (2019) 476 (5): 783–794.
Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes
Eri Sato; Yoshinori Maeda; Yui Sato; Airi Hinata; Hiroshi Gomi; Daisuke Koga; Seiji Torii; Tsuyoshi Watanabe; Masahiro Hosaka
Biochem J (2019) 476 (5): 827–842.
Structure of SPH (self-incompatibility protein homologue) proteins: a widespread family of small, highly stable, secreted proteins
Karthik V. Rajasekar; Shuangxi Ji; Rachel J. Coulthard; Jon P. Ride; Gillian L. Reynolds; Peter J. Winn; Michael J. Wheeler; Eva I. Hyde; Lorna J. Smith
Biochem J (2019) 476 (5): 809–826.
Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states
Anukool A. Bhopatkar; Gaurav Ghag; Lauren M. Wolf; Dexter N. Dean; Melissa A. Moss; Vijayaraghavan Rangachari
Biochem J (2019) 476 (5): 859–873.
Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
Apirat Chaikuad; Sebastian E. Koschade; Alexandra Stolz; Katarina Zivkovic; Christian Pohl; Shabnam Shaid; Huiyu Ren; Lester J. Lambert; Nicholas D.P. Cosford; Christian H. Brandts; Stefan Knapp
Biochem J (2019) 476 (5): 875–887.
Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity
Richa Dubey; Ketaki Patil; Sarath C. Dantu; Devika M. Sardesai; Parnika Bhatia; Nikita Malik; Jhankar D. Acharya; Soham Sarkar; Soumadwip Ghosh; Rajarshi Chakrabarti; Shilpy Sharma; Ashutosh Kumar
Biochem J (2019) 476 (5): 889–907.
