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Issues
January 2021
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Cover Image
Cover Image
Tumor organoids are a relevant, 3-dimensional, culture method which allows long-term growth preserving the stem cell identity and reconstituting to some extent the morphological and phenotypic heterogeneity of the original tumor. Representative fluorescence image of a tumour organoid derived from patient derived GSCs after 23 days of culture, stained for anti-αTubulin (microtubules, white) and Phalloidin (actin red). In this issue Pinto and colleagues (pp. 21–39) observed that different types of cell protrusions (TMs and TNTs) connecting cells were present and coexist inside the organoid. The image was captured by Inés Saenz-de-Santa-Maria with an inverted confocal microscope LSM700, Pln-Apo 10X/0.45 objective.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
Research Articles
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids
Giulia Pinto; Inés Saenz-de-Santa-Maria; Patricia Chastagner; Emeline Perthame; Caroline Delmas; Christine Toulas; Elizabeth Moyal-Jonathan-Cohen; Christel Brou; Chiara Zurzolo
Biochem J (2021) 478 (1): 21–39.
Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli
Keita Sugawara; Hayato Toyoda; Mami Kimura; Shunsuke Hayasaka; Hiromi Saito; Hiroshi Kobayashi; Kunio Ihara; Tomoaki Ida; Takaaki Akaike; Eiji Ando; Mamoru Hyodo; Yoshihiro Hayakawa; Shin Hamamoto; Nobuyuki Uozumi
Biochem J (2021) 478 (1): 41–59.
Hydrogen deuterium exchange mass spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody
Lukas Uhrik; Lenka Hernychova; Petr Muller; Umesh Kalathiya; Malgorzata M. Lisowska; Mikolaj Kocikowski; Maciej Parys; Jakub Faktor; Marta Nekulova; Chris Nortcliffe; Pavlina Zatloukalova; Barbara Ruetgen; Robin Fahraeus; Kathryn L. Ball; David J. Argyle; Borivoj Vojtesek; Ted R. Hupp
Biochem J (2021) 478 (1): 99–120.
Weakening of interaction networks with aging in tip-link protein induces hearing loss
Surbhi Garg; Amin Sagar; Gayathri S. Singaraju; Rahul Dani; Naimat K. Bari; Athi N. Naganathan; Sabyasachi Rakshit
Biochem J (2021) 478 (1): 121–134.
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells
Biochem J (2021) 478 (1): 179–196.
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner
Biochem J (2021) 478 (1): 197–215.
Stability of Smyd1 in endothelial cells is controlled by PML-dependent SUMOylation upon cytokine stimulation
Samuel Becker; Gustav Steinemann; Weronika Karle; Kerrin Roos; Celine Huajia Liem; Shalini Muralikumar; Andrea Volkamer; Barbara Munz; Andreas Zakrzewicz; Janine Berkholz
Biochem J (2021) 478 (1): 217–234.
The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression
Biochem J (2021) 478 (1): 247–260.
Review Articles
Commentaries
A new function for the xanthophyll zeaxanthin: glueing chlorophyll biosynthesis to thylakoid protein assembly
Biochem J (2021) 478 (1): 61–62.