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July 2021
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Cover Image
Cover Image
SMCHD1 is an epigenetic regulator that mediates gene expression silencing at targeted sites across the genome. In this issue Gurzau and colleagues (pp. 2555–2569) use biophysical techniques to we demonstrate that the SMCHD1 ATPase undergoes dimerization in a process that is dependent on both the N-terminal Ubiquitin-like domain and ATP binding. The cover image shows immunofluorescence with DAPI staining in cyan and SMCHD1 showing in yellow. Scale bars are 20 µm. Image provided by James M. Murphy.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
Commentaries
Review Articles
Research Articles
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
Jingkun Zeng; Florian Weissmann; Agustina P. Bertolin; Viktor Posse; Berta Canal; Rachel Ulferts; Mary Wu; Ruth Harvey; Saira Hussain; Jennifer C. Milligan; Chloe Roustan; Annabel Borg; Laura McCoy; Lucy S. Drury; Svend Kjaer; John McCauley; Michael Howell; Rupert Beale; John F.X. Diffley
Biochem J (2021) 478 (13): 2405–2423.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase
Agustina P. Bertolin; Florian Weissmann; Jingkun Zeng; Viktor Posse; Jennifer C. Milligan; Berta Canal; Rachel Ulferts; Mary Wu; Lucy S. Drury; Michael Howell; Rupert Beale; John F.X. Diffley
Biochem J (2021) 478 (13): 2425–2443.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
Berta Canal; Allison W. McClure; Joseph F. Curran; Mary Wu; Rachel Ulferts; Florian Weissmann; Jingkun Zeng; Agustina P. Bertolin; Jennifer C. Milligan; Souradeep Basu; Lucy S. Drury; Tom D. Deegan; Ryo Fujisawa; Emma L. Roberts; Clovis Basier; Karim Labib; Rupert Beale; Michael Howell; John F.X. Diffley
Biochem J (2021) 478 (13): 2445–2464.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
Berta Canal; Ryo Fujisawa; Allison W. McClure; Tom D. Deegan; Mary Wu; Rachel Ulferts; Florian Weissmann; Lucy S. Drury; Agustina P. Bertolin; Jingkun Zeng; Rupert Beale; Michael Howell; Karim Labib; John F.X. Diffley
Biochem J (2021) 478 (13): 2465–2479.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
Souradeep Basu; Tiffany Mak; Rachel Ulferts; Mary Wu; Tom Deegan; Ryo Fujisawa; Kang Wei Tan; Chew Theng Lim; Clovis Basier; Berta Canal; Joseph F. Curran; Lucy S. Drury; Allison W. McClure; Emma L. Roberts; Florian Weissmann; Theresa U. Zeisner; Rupert Beale; Victoria H. Cowling; Michael Howell; Karim Labib; John F.X. Diffley
Biochem J (2021) 478 (13): 2481–2497.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
Jennifer C. Milligan; Theresa U. Zeisner; George Papageorgiou; Dhira Joshi; Christelle Soudy; Rachel Ulferts; Mary Wu; Chew Theng Lim; Kang Wei Tan; Florian Weissmann; Berta Canal; Ryo Fujisawa; Tom Deegan; Hema Nagaraj; Ganka Bineva-Todd; Clovis Basier; Joseph F. Curran; Michael Howell; Rupert Beale; Karim Labib; Nicola O'Reilly; John F.X. Diffley
Biochem J (2021) 478 (13): 2499–2515.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
Chew Theng Lim; Kang Wei Tan; Mary Wu; Rachel Ulferts; Lee A. Armstrong; Eiko Ozono; Lucy S. Drury; Jennifer C. Milligan; Theresa U. Zeisner; Jingkun Zeng; Florian Weissmann; Berta Canal; Ganka Bineva-Todd; Michael Howell; Nicola O'Reilly; Rupert Beale; Yogesh Kulathu; Karim Labib; John F.X. Diffley
Biochem J (2021) 478 (13): 2517–2531.
Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment
Biochem J (2021) 478 (13): 2539–2553.
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii
Carolina Conter; Luca Bombardi; Marco Pedretti; Filippo Favretto; Adele Di Matteo; Paola Dominici; Alessandra Astegno
Biochem J (2021) 478 (13): 2571–2587.
Hetero-oligomerization of Bacillus thuringiensis Cry1A proteins enhance binding to the ABCC2 transporter of Spodoptera exigua
Biochem J (2021) 478 (13): 2589–2600.
Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site
Víctor Juarez-Quintero; Antolín Peralta-Castro; Claudia G. Benítez Cardoza; Tom Ellenberger; Luis G. Brieba
Biochem J (2021) 478 (13): 2665–2679.
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
Tess R. Malcolm; Karolina W. Swiderska; Brooke K. Hayes; Chaille T. Webb; Marcin Drag; Nyssa Drinkwater; Sheena McGowan
Biochem J (2021) 478 (13): 2697–2713.
Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha
Hamine C. de Oliveira; Tainá D. da Silva; Guilherme H. M. Salvador; Ivan R. Moraes; Cíntia A. Fukuda; Andrea C. de Barros; Marcos R. M. Fontes
Biochem J (2021) 478 (13): 2715–2732.
Correspondence
Corrections
Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity
Biochem J (2021) 478 (13): 2537–2538.
