Parp7 is part of an androgen signaling axis that controls its expression in prostate cancer cells. Kamata and colleagues (pp. 2999–3014) show that Parp7 selectively ADP-ribosylates the agonist conformation of the androgen receptor (AR). The cover image shows nuclear localization of Parp7 (red) and AR (green) in prostate cancer cells using confocal scanning microscopy. Co-localization of Parp7 and AR (yellow) and DAPI staining of DNA (blue) is also shown. Image provided by Natalia Dworak, Chun-Song Yang, and Bryce Paschal.