Issues

In this issue, Witus and colleagues (pp. 3467–3483) discuss the Ub ligase function of BRCA1/BARD1, highlighting experimental approaches, mechanistic considerations, and reagents that are useful in the study of substrate ubiquitylation. The review also looks at the current understanding of two well established BRCA1/BARD1 substrates and several recently discovered substrates. The cover image shows that BRCA1 and BARD1 bind the nucleosome substrate and E2 simultaneously. Image courtesy of Rachel E. Klevit.