Issues

In this issue Voronkova et al. (pp. 1411–1427) characterize mutations disrupting an evolutionarily conserved salt bridge between aspartic acid and arginine in human platelet (PFKP) and liver (PFKL) isoforms. Their results suggest that mutations in Arg–Asp pair at the interface of the catalytic-regulatory domains stabilizes the t-state and presents novel mechanistic insight for therapeutic development in cancer. The image is a painting titled Phosphofructokinase-1, the ‘gatekeeper of glycolysis’. Painting by Madison Cooper, West Virginia University, USA.