Issues

In this issue, Hodapp and colleagues (pp. 759–775) examine the effect of four cancer-associated mutations, R145H/C in the autoinhibitory pseudosubstrate, E161K in the regulatory C1A domain, and R635W in the regulatory C-terminal tail, on the cellular activity and stability of PKCθ. Their results reveal that PKCθ function is lost in cancer. The cover image model structure of PKCθ in its autoinhibited conformation. The image is courtesy of Alexandra Newton.