Issues

ADP-ribosylation is a prominent and versatile post-translational modification, which regulates a diverse set of cellular processes. Poly-ADP-ribose (PAR) is synthesised by the poly-ADP-ribosyltransferases PARP1, PARP2, tankyrase (TNKS), and tankyrase 2 (TNKS2), all of which are linked to human disease. In this issue, Jessop and colleagues (pp. 1097–1123) compare these poly-ADP-ribosyltransferases and point towards emerging parallels and open questions, whose pursuit will inform future drug development efforts. The cover image shows the cryo-EM map of the TNKS2 SAM-ART^G1032W filament (EMD-15520). The image is courtesy of Sebastian Guettler.