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April 2025
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Cover Image
The cover of this issue of the Biochemical Journal features a 3-D rendered image of dividing cancer cells. In this issue, Li et al. investigate the links between PRL2, miR-21 and PTEN. Their research provides evidence that PRL2 serves as a negative regulator of PTEN. Reductions in PTEN significantly impact cancer development and progression, and therefore the therapeutic targeting of PRL2 is a promising strategy for cancer treatment. Read more at: https://doi.org/10.1042/BCJ20240626
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ISSN 0264-6021
EISSN 1470-8728
In this Issue
The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor
Qinglin Li; Yunpeng Bai; Sarah M. Cavender; Yiming Miao; Frederick Nguele Meke; Emily L. Lasse-Opsahl; Peipei Zhu; Gina M. Doody; W. Andy Tao; Zhong-Yin Zhang
Biochem J (2025) 482 (07): 341–356.