Issues

The cover of this issue of the Biochemical Journal details Cardiac ketone metabolism in type 2 diabetes (T2D). During T2D, there is a down-regulation of BDH1 protein expression and an up-regulation of SCOT activity (as indicated by the red arrows), which may explain contrasting findings on whether ketone oxidation is decreased or increased in the diabetic heart depending on which ketone substrate is being provided (AcAc or ßOHB). AcAc, acetoacetate; AcAc-CoA, acetoacetyl CoA; ACAT, acetoacetyl CoA thiolase; ATP, adenosine triphosphate; ßOHB, ß-hydroxybutyrate; BDH1, ß-hydroxybutyrate dehydrogenase 1; ETC, electron transport chain; FADH2, flavin adenine dinucleotide; MCT1, monocarboxylic acid transporter 1; NADH, nicotinamide adenine dinucleotide; SCOT, succinyl CoA:3-ketoacid CoA transferase; T2D, type 2 diabetes; TCA, tricarboxylic acid. Created in Biorender.com. Read more here: https://doi.org/10.1042/BCJ20240189