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A E Pegg
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Articles

Stable intracellular acidification upon polyamine depletion induced by α -difluoromethylornithine or N 1 , N 12 -bis(ethyl)spermine in L1210 leukaemia cells

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R Poulin, A E Pegg
Journal: Biochemical Journal
Biochem J (1995) 312 (3): 749–756.
https://doi.org/10.1042/bj3120749
Published: 15 December 1995
View articletitled, Stable intracellular acidification upon polyamine depletion induced by α -difluoromethylornithine or N 1 , N 12 -bis(ethyl)spermine in L1210 leukaemia cells
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Articles

Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells

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R Poulin, G Pelletier, A E Pegg
Journal: Biochemical Journal
Biochem J (1995) 311 (3): 723–727.
https://doi.org/10.1042/bj3110723
Published: 01 November 1995
View articletitled, Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells
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Articles

Post-transcriptional regulation of the content of spermidine/spermine N 1 -acetyltransferase by N 1 N 12 -bis(ethyl)spermine

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L Parry, R Balaña Fouce, A E Pegg
Journal: Biochemical Journal
Biochem J (1995) 305 (2): 451–458.
https://doi.org/10.1042/bj3050451
Published: 15 January 1995
View articletitled, Post-transcriptional regulation of the content of spermidine/spermine N 1 -acetyltransferase by N 1 N 12 -bis(ethyl)spermine
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Articles

The role of hypusine depletion in cytostasis induced by S-adenosyl-l-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine

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T L Byers, J R Lakanen, J K Coward, A E Pegg
Journal: Biochemical Journal
Biochem J (1994) 303 (2): 363–368.
https://doi.org/10.1042/bj3030363
Published: 15 October 1994
View articletitled, The role of hypusine depletion in cytostasis induced by S-adenosyl-l-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine
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Articles

Effects of the S -adenosylmethionine decarboxylase inhibitor, 5′-{[(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures

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T L Byers, R S Wechter, R H Hu, A E Pegg
Journal: Biochemical Journal
Biochem J (1994) 303 (1): 89–96.
https://doi.org/10.1042/bj3030089
Published: 01 October 1994
View articletitled, Effects of the S -adenosylmethionine decarboxylase inhibitor, 5′-{[(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures
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Articles

Role of the 5′-untranslated region of mRNA in the synthesis of S -adenosylmethionine decarboxylase and its regulation by spermine

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L M Shantz, R Viswanath, A E Pegg
Journal: Biochemical Journal
Biochem J (1994) 302 (3): 765–772.
https://doi.org/10.1042/bj3020765
Published: 15 September 1994
View articletitled, Role of the 5′-untranslated region of mRNA in the synthesis of S -adenosylmethionine decarboxylase and its regulation by spermine
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Articles

Investigations of the mechanism by which mammalian cell growth is inhibited by N 1 N 12 -bis(ethyl)spermine

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L Albanese, R J Bergeron, A E Pegg
Journal: Biochemical Journal
Biochem J (1993) 291 (1): 131–137.
https://doi.org/10.1042/bj2910131
Published: 01 April 1993
View articletitled, Investigations of the mechanism by which mammalian cell growth is inhibited by N 1 N 12 -bis(ethyl)spermine
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Articles

Effects of chronic 5′-{[( Z )-4-amino-2-butenyl]methylamino)-5′-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells

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T L Byers, L Wiest, R S Wechter, A E Pegg
Journal: Biochemical Journal
Biochem J (1993) 290 (1): 115–121.
https://doi.org/10.1042/bj2900115
Published: 15 February 1993
View articletitled, Effects of chronic 5′-{[( Z )-4-amino-2-butenyl]methylamino)-5′-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells
Open the PDF for Effects of chronic 5′-{[( Z )-4-amino-2-butenyl]methylamino)-5′-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells in another window
Articles

Regulation of S -adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content

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L M Shantz, I Holm, O A Jänne, A E Pegg
Journal: Biochemical Journal
Biochem J (1992) 288 (2): 511–518.
https://doi.org/10.1042/bj2880511
Published: 01 December 1992
View articletitled, Regulation of S -adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content
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Articles

Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-l-methionine decarboxylase inhibitor 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine may be due to hypusine depletion

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T L Byers, B Ganem, A E Pegg
Journal: Biochemical Journal
Biochem J (1992) 287 (3): 717–724.
https://doi.org/10.1042/bj2870717
Published: 01 November 1992
View articletitled, Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-l-methionine decarboxylase inhibitor 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine may be due to hypusine depletion
Open the PDF for Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-l-methionine decarboxylase inhibitor 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine may be due to hypusine depletion in another window
Articles

Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover

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L Lu, B A Stanley, A E Pegg
Journal: Biochemical Journal
Biochem J (1991) 277 (3): 671–675.
https://doi.org/10.1042/bj2770671
Published: 01 August 1991
View articletitled, Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover
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Articles

Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells

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A E Pegg, S Nagarajan, S Naficy, B Ganem
Journal: Biochemical Journal
Biochem J (1991) 274 (1): 167–171.
https://doi.org/10.1042/bj2740167
Published: 15 February 1991
View articletitled, Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells
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Articles

High specific induction of spermidine/spermine N 1 -acetyltransferase in a human large cell lung carcinoma

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R A Casero, Jr, P Celano, S J Ervin, L Wiest, A E Pegg
Journal: Biochemical Journal
Biochem J (1990) 270 (3): 615–620.
https://doi.org/10.1042/bj2700615
Published: 15 September 1990
View articletitled, High specific induction of spermidine/spermine N 1 -acetyltransferase in a human large cell lung carcinoma
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Articles

Combined regulation of ornithine and S -adenosylmethionine decarboxylases by spermine and the spermine analogue N 1 N 12 -bis(ethyl)spermine

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C W Porter, A E Pegg, B Ganis, R Madhabala, R J Bergeron
Journal: Biochemical Journal
Biochem J (1990) 268 (1): 207–212.
https://doi.org/10.1042/bj2680207
Published: 15 May 1990
View articletitled, Combined regulation of ornithine and S -adenosylmethionine decarboxylases by spermine and the spermine analogue N 1 N 12 -bis(ethyl)spermine
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Articles

Induction of spermidine/spermine N 1 -acetyltransferase activity in Chinese-hamster ovary cells by N 1 N 11 -bis(ethyl)norspermine (corrected) and related compounds

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A E Pegg, R Pakala, R J Bergeron
Journal: Biochemical Journal
Biochem J (1990) 267 (2): 331–338.
https://doi.org/10.1042/bj2670331
Published: 15 April 1990
View articletitled, Induction of spermidine/spermine N 1 -acetyltransferase activity in Chinese-hamster ovary cells by N 1 N 11 -bis(ethyl)norspermine (corrected) and related compounds
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Articles

Expression of a human gene for polyamine transport in Chinese-hamster ovary cells

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T L Byers, R Wechter, M E Nuttall, A E Pegg
Journal: Biochemical Journal
Biochem J (1989) 263 (3): 745–752.
https://doi.org/10.1042/bj2630745
Published: 01 November 1989
View articletitled, Expression of a human gene for polyamine transport in Chinese-hamster ovary cells
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Articles

Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells

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R Poulin, J A Secrist, 3rd, A E Pegg
Journal: Biochemical Journal
Biochem J (1989) 263 (1): 215–221.
https://doi.org/10.1042/bj2630215
Published: 01 October 1989
View articletitled, Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells
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Articles

Effects of S -adenosyl-1,8-diamino-3-thio-octane and S -methyl-5′-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells

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I Holm, L Persson, A E Pegg, O Heby
Journal: Biochemical Journal
Biochem J (1989) 261 (1): 205–210.
https://doi.org/10.1042/bj2610205
Published: 01 July 1989
View articletitled, Effects of S -adenosyl-1,8-diamino-3-thio-octane and S -methyl-5′-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells
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Articles

Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to α-difluoromethylornithine

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S Nagarajan, B Ganem, A E Pegg
Journal: Biochemical Journal
Biochem J (1988) 254 (2): 373–378.
https://doi.org/10.1042/bj2540373
Published: 01 September 1988
View articletitled, Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to α-difluoromethylornithine
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Articles

Effect of inhibitors of S -adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S -adenosylmethionine decarboxylase in L1210 cells

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R Madhubala, J A Secrist, 3rd, A E Pegg
Journal: Biochemical Journal
Biochem J (1988) 254 (1): 45–50.
https://doi.org/10.1042/bj2540045
Published: 15 August 1988
View articletitled, Effect of inhibitors of S -adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S -adenosylmethionine decarboxylase in L1210 cells
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Articles

Increase in S -adenosylmethionine decarboxylase in SV-3T3 cells treated with S -methyl-5′-methylthioadenosine

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A E Pegg, R Wechter, A Pajunen
Journal: Biochemical Journal
Biochem J (1987) 244 (1): 49–54.
https://doi.org/10.1042/bj2440049
Published: 15 May 1987
View articletitled, Increase in S -adenosylmethionine decarboxylase in SV-3T3 cells treated with S -methyl-5′-methylthioadenosine
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Articles

Effect of putrescine on the synthesis of S -adenosylmethionine decarboxylase

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T Kameji, A E Pegg
Journal: Biochemical Journal
Biochem J (1987) 243 (1): 285–288.
https://doi.org/10.1042/bj2430285
Published: 01 April 1987
View articletitled, Effect of putrescine on the synthesis of S -adenosylmethionine decarboxylase
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Articles

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N 1 N 8 -bis(ethyl)spermidine

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C W Porter, F G Berger, A E Pegg, B Ganis, R J Bergeron
Journal: Biochemical Journal
Biochem J (1987) 242 (2): 433–440.
https://doi.org/10.1042/bj2420433
Published: 01 March 1987
View articletitled, Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N 1 N 8 -bis(ethyl)spermidine
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Articles

Decarboxylation of α -difluoromethylornithine by ornithine decarboxylase

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A E Pegg, K A McGovern, L Wiest
Journal: Biochemical Journal
Biochem J (1987) 241 (1): 305–307.
https://doi.org/10.1042/bj2410305
Published: 01 January 1987
View articletitled, Decarboxylation of α -difluoromethylornithine by ornithine decarboxylase
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Articles

Regulation of spermidine/spermine N 1 -acetyltransferase in L6 cells by polyamines and related compounds

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B G Erwin, A E Pegg
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 581–587.
https://doi.org/10.1042/bj2380581
Published: 01 September 1986
View articletitled, Regulation of spermidine/spermine N 1 -acetyltransferase in L6 cells by polyamines and related compounds
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Articles

Recent advances in the biochemistry of polyamines in eukaryotes

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A E Pegg
Journal: Biochemical Journal
Biochem J (1986) 234 (2): 249–262.
https://doi.org/10.1042/bj2340249
Published: 01 March 1986
View articletitled, Recent advances in the biochemistry of polyamines in eukaryotes
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Articles

Escherichia coli S -adenosylhomocysteine/5′-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action

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F Della Ragione, M Porcelli, M Cartenì-Farina, V Zappia, A E Pegg
Journal: Biochemical Journal
Biochem J (1985) 232 (2): 335–341.
https://doi.org/10.1042/bj2320335
Published: 01 December 1985
View articletitled, Escherichia coli S -adenosylhomocysteine/5′-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action
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Articles

Induction of spermidine/spermine N 1 -acetyltransferase in rat tissues by polyamines

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A E Pegg, B G Erwin
Journal: Biochemical Journal
Biochem J (1985) 231 (2): 285–289.
https://doi.org/10.1042/bj2310285
Published: 15 October 1985
View articletitled, Induction of spermidine/spermine N 1 -acetyltransferase in rat tissues by polyamines
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Articles

Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney

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J E Seely, L Persson, G J Sertich, A E Pegg
Journal: Biochemical Journal
Biochem J (1985) 226 (2): 577–586.
https://doi.org/10.1042/bj2260577
Published: 01 March 1985
View articletitled, Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney
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Articles

The role of polyamine depletion and accumulation of decarboxylated S -adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with α-difluoromethylornithine

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A E Pegg
Journal: Biochemical Journal
Biochem J (1984) 224 (1): 29–38.
https://doi.org/10.1042/bj2240029
Published: 15 November 1984
View articletitled, The role of polyamine depletion and accumulation of decarboxylated S -adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with α-difluoromethylornithine
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Articles

Studies of mammalian ornithine decarboxylase using a monoclonal antibody

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A E Pegg, J E Seely, L Persson, M Herlyn, K Ponsell, T G O'Brien
Journal: Biochemical Journal
Biochem J (1984) 217 (1): 123–128.
https://doi.org/10.1042/bj2170123
Published: 01 January 1984
View articletitled, Studies of mammalian ornithine decarboxylase using a monoclonal antibody
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Articles

Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver

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J E Seely, A E Pegg
Journal: Biochemical Journal
Biochem J (1983) 216 (3): 701–707.
https://doi.org/10.1042/bj2160701
Published: 15 December 1983
View articletitled, Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver
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Articles

Studies of the specificity and kinetics of rat liver spermidine/spermine N 1 -acetyltransferase

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F Della Ragione, A E Pegg
Journal: Biochemical Journal
Biochem J (1983) 213 (3): 701–706.
https://doi.org/10.1042/bj2130701
Published: 01 September 1983
View articletitled, Studies of the specificity and kinetics of rat liver spermidine/spermine N 1 -acetyltransferase
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Articles

Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N 1 -acetyltransferase

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F Della Ragione, B G Erwin, A E Pegg
Journal: Biochemical Journal
Biochem J (1983) 213 (3): 707–712.
https://doi.org/10.1042/bj2130707
Published: 01 September 1983
View articletitled, Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N 1 -acetyltransferase
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Articles

Comparison of inhibitors of S -adenosylmethionine decarboxylase from different species

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A E Pegg, G Jacobs
Journal: Biochemical Journal
Biochem J (1983) 213 (2): 495–502.
https://doi.org/10.1042/bj2130495
Published: 01 August 1983
View articletitled, Comparison of inhibitors of S -adenosylmethionine decarboxylase from different species
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Articles

Effect of analogues of 5′-methylthioadenosine on cellular metabolism. Inactivation of S -adenosylhomocysteine hydrolase by 5′-isobutylthioadenosine

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F Della Ragione, A E Pegg
Journal: Biochemical Journal
Biochem J (1983) 210 (2): 429–435.
https://doi.org/10.1042/bj2100429
Published: 15 February 1983
View articletitled, Effect of analogues of 5′-methylthioadenosine on cellular metabolism. Inactivation of S -adenosylhomocysteine hydrolase by 5′-isobutylthioadenosine
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Articles

Differences between tissues in response of S -adenosylmethionine decarboxylase to administration of polyamines

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H Pösö, A E Pegg
Journal: Biochemical Journal
Biochem J (1981) 200 (3): 629–637.
https://doi.org/10.1042/bj2000629
Published: 15 December 1981
View articletitled, Differences between tissues in response of S -adenosylmethionine decarboxylase to administration of polyamines
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Articles

Specificity of mammalian spermidine synthase and spermine synthase

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A E Pegg, K Shuttleworth, H Hibasami
Journal: Biochemical Journal
Biochem J (1981) 197 (2): 315–320.
https://doi.org/10.1042/bj1970315
Published: 01 August 1981
View articletitled, Specificity of mammalian spermidine synthase and spermine synthase
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Articles

Effect of partial hepatectomy on removal of O 6 -methylguanine from alkylated DNA by rat liver extracts

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A E Pegg, W Perry, R A Bennett
Journal: Biochemical Journal
Biochem J (1981) 197 (1): 195–201.
https://doi.org/10.1042/bj1970195
Published: 01 July 1981
View articletitled, Effect of partial hepatectomy on removal of O 6 -methylguanine from alkylated DNA by rat liver extracts
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Articles

Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts

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D R Bethell, A E Pegg
Journal: Biochemical Journal
Biochem J (1979) 180 (1): 87–94.
https://doi.org/10.1042/bj1800087
Published: 15 April 1979
View articletitled, Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts
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Articles

Effects of aliphatic diamines on rat liver ornithine decarboxylase activity

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A E Pegg, C Conover, A Wrona
Journal: Biochemical Journal
Biochem J (1978) 170 (3): 651–660.
https://doi.org/10.1042/bj1700651
Published: 15 March 1978
View articletitled, Effects of aliphatic diamines on rat liver ornithine decarboxylase activity
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Articles

Rapid and convenient method for the assay of aminopropyltransferases

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H Hibasami, A E Pegg
Journal: Biochemical Journal
Biochem J (1978) 169 (3): 709–712.
https://doi.org/10.1042/bj1690709
Published: 01 March 1978
View articletitled, Rapid and convenient method for the assay of aminopropyltransferases
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Articles

Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S -adenosylmethionine decarboxylase activity

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A E Pegg
Journal: Biochemical Journal
Biochem J (1977) 166 (1): 81–88.
https://doi.org/10.1042/bj1660081
Published: 15 July 1977
View articletitled, Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S -adenosylmethionine decarboxylase activity
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Articles

A reappraisal of the effects of adenosine 3′:5′-cyclic monophosphate on the function and morphology of the rat prostate gland

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F. R. Mangan, A. E. Pegg, W. I. P. Mainwaring
Journal: Biochemical Journal
Biochem J (1973) 134 (1): 129–142.
https://doi.org/10.1042/bj1340129
Published: 15 May 1973
View articletitled, A reappraisal of the effects of adenosine 3′:5′-cyclic monophosphate on the function and morphology of the rat prostate gland
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Articles

Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone)

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A. E. Pegg
Journal: Biochemical Journal
Biochem J (1973) 132 (3): 537–540.
https://doi.org/10.1042/bj1320537
Published: 15 March 1973
View articletitled, Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone)
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Articles

Specificity of transfer ribonucleic acid methylases from normal mouse colon and 1,2-dimethylhydrazine-induced colon tumours

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A E Pegg
Journal: Biochemical Journal
Biochem J (1972) 129 (3): 40P.
https://doi.org/10.1042/bj1290040P
Published: 01 September 1972
View articletitled, Specificity of transfer ribonucleic acid methylases from normal mouse colon and 1,2-dimethylhydrazine-induced colon tumours
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Articles

Studies of the ethylation of rat liver transfer ribonucleic acid after administration of l-ethionine

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A. E. Pegg
Journal: Biochemical Journal
Biochem J (1972) 128 (1): 59–68.
https://doi.org/10.1042/bj1280059
Published: 01 June 1972
View articletitled, Studies of the ethylation of rat liver transfer ribonucleic acid after administration of l-ethionine
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Articles

Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine

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P. F. Swann, A. E. Pegg, A. Hawks, E. Farber, P. N. Magee
Journal: Biochemical Journal
Biochem J (1971) 123 (2): 175–181.
https://doi.org/10.1042/bj1230175
Published: 01 June 1971
View articletitled, Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine
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Articles

Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine

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A E Pegg, A Hawks
Journal: Biochemical Journal
Biochem J (1971) 122 (1): 121–123.
https://doi.org/10.1042/bj1220121
Published: 01 March 1971
View articletitled, Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine
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Articles

Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth

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A. E. Pegg, D. H. Lockwood, H. G. Williams-Ashman
Journal: Biochemical Journal
Biochem J (1970) 117 (1): 17–31.
https://doi.org/10.1042/bj1170017
Published: 01 March 1970
View articletitled, Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth
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