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Akira HARA
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Articles

Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells

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Momoko YAMADA, Yoshiko BANNO, Yoh TAKUWA, Masahiro KODA, Akira HARA, Yoshinori NOZAWA
Journal: Biochemical Journal
Biochem J (2004) 378 (2): 649–656.
https://doi.org/10.1042/bj20031398
Published: 01 March 2004
View articletitled, Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells
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Articles

Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells

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Yoshiko BANNO, Yoh TAKUWA, Momoko YAMADA, Noriko TAKUWA, Kenji OHGUCHI, Akira HARA, Yoshinori NOZAWA
Journal: Biochemical Journal
Biochem J (2003) 369 (2): 363–368.
https://doi.org/10.1042/bj20021368
Published: 15 January 2003
View articletitled, Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells
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Articles

Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo–keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α

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Takeshi OZEKI, Yoshiki TAKAHASHI, Toshiyuki KUME, Kazuo NAKAYAMA, Tsuyoshi YOKOI, Ken-Ichi NUNOYA, Akira HARA, Tetsuya KAMATAKI
Journal: Biochemical Journal
Biochem J (2001) 355 (2): 537–544.
https://doi.org/10.1042/bj3550537
Published: 06 April 2001
View articletitled, Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo–keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α
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Articles

Kinetic alteration of a human dihydrodiol/3α-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine

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Tatuya OHTA, Syuhei ISHIKURA, Syunichi SHINTANI, Noriyuki USAMI, Akira HARA
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 685–691.
https://doi.org/10.1042/bj3520685
Published: 08 December 2000
View articletitled, Kinetic alteration of a human dihydrodiol/3α-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine
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Articles

Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases

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Eiji ARIMITSU, Shinya AOKI, Syuhei ISHIKURA, Kumiko NAKANISHI, Kazuya MATSUURA, Akira HARA
Journal: Biochemical Journal
Biochem J (1999) 342 (3): 721–728.
https://doi.org/10.1042/bj3420721
Published: 05 September 1999
View articletitled, Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases
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Articles

Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes

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Kazuya MATSUURA, Akira HARA, Yoshihiro DEYASHIKI, Harunori IWASA, Toshiyuki KUME, Syuhei ISHIKURA, Hiroaki SHIRAISHI, Yoshihiro KATAGIRI
Journal: Biochemical Journal
Biochem J (1998) 336 (2): 429–436.
https://doi.org/10.1042/bj3360429
Published: 01 December 1998
View articletitled, Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes
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Articles

Evidence for the presence of multiple forms of Sph kinase in human platelets

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Yoshiko BANNO, Makiko KATO, Akira HARA, Yoshinori NOZAWA
Journal: Biochemical Journal
Biochem J (1998) 335 (2): 301–304.
https://doi.org/10.1042/bj3350301
Published: 15 October 1998
View articletitled, Evidence for the presence of multiple forms of Sph kinase in human platelets
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Articles

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA

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Hiroaki SHIRAISHI, Syuhei ISHIKURA, Kazuya MATSUURA, Yoshihiro DEYASHIKI, Mitsuo NINOMIYA, Syunsuke SAKAI, Akira HARA
Journal: Biochemical Journal
Biochem J (1998) 334 (2): 399–405.
https://doi.org/10.1042/bj3340399
Published: 01 September 1998
View articletitled, Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA
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Articles

Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis

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Kazuya MATSUURA, Yoshihiro DEYASHIKI, Kumiko SATO, Naoko ISHIDA, Gunpei MIWA, Akira HARA
Journal: Biochemical Journal
Biochem J (1997) 323 (1): 61–64.
https://doi.org/10.1042/bj3230061
Published: 01 April 1997
View articletitled, Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis
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Articles

Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3α-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis

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Kazuya MATSUURA, Yoshiyuki TAMADA, Kumiko SATO, Harunori IWASA, Gunpei MIWA, Yoshihiro DEYASHIKI, Akira HARA
Journal: Biochemical Journal
Biochem J (1997) 322 (1): 89–93.
https://doi.org/10.1042/bj3220089
Published: 15 February 1997
View articletitled, Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3α-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis
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Articles

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

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Akira HARA, Kazuya MATSUURA, Yoshiyuki TAMADA, Kumiko SATO, Yoshiyuki MIYABE, Yoshihiro DEYASHIKI, Naoko ISHIDA
Journal: Biochemical Journal
Biochem J (1996) 313 (2): 373–376.
https://doi.org/10.1042/bj3130373
Published: 15 January 1996
View articletitled, Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells
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Articles

Activation of human liver 3α-hydroxysteroid dehydrogenase by sulphobromophthalein

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Kazuya MATSUURA, Yoshiyuki TAMADA, Yoshihiro DEYASHIKI, Yoshiyuki MIYABE, Masayuki NAKANISHI, Isao OHYA, Akira HARA
Journal: Biochemical Journal
Biochem J (1996) 313 (1): 179–184.
https://doi.org/10.1042/bj3130179
Published: 01 January 1996
View articletitled, Activation of human liver 3α-hydroxysteroid dehydrogenase by sulphobromophthalein
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