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Alan R. PRESCOTT
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Articles

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2022) 479 (17): 1759–1783.
https://doi.org/10.1042/BCJ20220161
Published: 06 September 2022
View article titled, Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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Includes: Supplementary data
Articles

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2022) 479 (16): 1709–1725.
https://doi.org/10.1042/BCJ20220184
Published: 31 August 2022
View article titled, Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
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Includes: Supplementary data
Articles

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Nazma Malik, Raja S. Nirujogi, Julien Peltier, Thomas Macartney, Melanie Wightman, Alan R. Prescott, Robert Gourlay, Matthias Trost, Dario R. Alessi, Athanasios Karapetsas
Journal: Biochemical Journal
Biochem J (2019) 476 (20): 3081–3107.
https://doi.org/10.1042/BCJ20190608
Published: 30 October 2019
View article titled, Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44
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Includes: Supplementary data
Articles

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

Nazma Malik, Thomas Macartney, Annika Hornberger, Karen E. Anderson, Hannah Tovell, Alan R. Prescott, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 117–135.
https://doi.org/10.1042/BCJ20170650
Published: 02 January 2018
View article titled, Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks
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Includes: Supplementary data
Articles

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

James Ozanne, Alan R. Prescott, Kristopher Clark
Journal: Biochemical Journal
Biochem J (2015) 465 (2): 271–279.
https://doi.org/10.1042/BJ20141165
Published: 06 January 2015
View article titled, The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases
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Includes: Supplementary data
Articles

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2014) 463 (3): 413–427.
https://doi.org/10.1042/BJ20140889
Published: 10 October 2014
View article titled, Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
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Includes: Supplementary data
Articles

Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex

Grant English, Olwyn Byron, Francesca R. Cianfanelli, Alan R. Prescott, Sarah J. Coulthurst
Journal: Biochemical Journal
Biochem J (2014) 461 (2): 291–304.
https://doi.org/10.1042/BJ20131426
Published: 26 June 2014
View article titled, Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex
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Articles

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Sourav Banerjee, Anna Zagórska, Maria Deak, David G. Campbell, Alan R. Prescott, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2014) 461 (2): 233–245.
https://doi.org/10.1042/BJ20140408
Published: 26 June 2014
View article titled, Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase
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Includes: Supplementary data
Articles

Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

Stewart M. Coleman, Alan R. Prescott, Judith E. Sleeman
Journal: Biochemical Journal
Biochem J (2014) 458 (2): 267–280.
https://doi.org/10.1042/BJ20130870
Published: 14 February 2014
View article titled, Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1
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Includes: Multimedia, Supplementary data
Articles

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Sourav Banerjee, Sara J. Buhrlage, Hai-Tsang Huang, Xianming Deng, Wenjun Zhou, Jinhua Wang, Ryan Traynor, Alan R. Prescott, Dario R. Alessi, Nathanael S. Gray
Journal: Biochemical Journal
Biochem J (2014) 457 (1): 215–225.
https://doi.org/10.1042/BJ20131152
Published: 10 December 2013
View article titled, Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
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Includes: Multimedia, Supplementary data
Articles

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

Amy R. Cameron, Katherine Wallace, Lisa Logie, Alan R. Prescott, Terry G. Unterman, Jean Harthill, Graham Rena
Journal: Biochemical Journal
Biochem J (2012) 443 (1): 57–64.
https://doi.org/10.1042/BJ20112124
Published: 14 March 2012
View article titled, The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a
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Articles

ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

Kumara Dissanayake, Rachel Toth, Jamie Blakey, Olof Olsson, David G. Campbell, Alan R. Prescott, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2011) 433 (3): 515–525.
https://doi.org/10.1042/BJ20101562
Published: 14 January 2011
View article titled, ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa
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Includes: Supplementary data
Articles

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Nicolas Dzamko, Maria Deak, Faycal Hentati, Alastair D. Reith, Alan R. Prescott, Dario R. Alessi, R. Jeremy Nichols
Journal: Biochemical Journal
Biochem J (2010) 430 (3): 405–413.
https://doi.org/10.1042/BJ20100784
Published: 27 August 2010
View article titled, Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization
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Includes: Supplementary data
Articles

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2010) 430 (3): 393–404.
https://doi.org/10.1042/BJ20100483
Published: 27 August 2010
View article titled, 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
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Includes: Supplementary data
Articles

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Mahaboobi Jaleel, Fabrizio Villa, Maria Deak, Rachel Toth, Alan R. Prescott, Daan M. F. van Aalten, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2006) 394 (3): 545–555.
https://doi.org/10.1042/BJ20051844
Published: 24 February 2006
View article titled, The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
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Articles

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Ian N. FLEMING, Ian H. BATTY, Alan R. PRESCOTT, Alex GRAY, Gursant S. KULAR, Hazel STEWART, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2004) 382 (3): 857–865.
https://doi.org/10.1042/BJ20040916
Published: 07 September 2004
View article titled, Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
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Articles

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Alberto C. VITARI, Maria DEAK, Barry J. COLLINS, Nick MORRICE, Alan R. PRESCOTT, Anne PHELAN, Sian HUMPHREYS, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2004) 378 (1): 257–268.
https://doi.org/10.1042/bj20031692
Published: 15 February 2004
View article titled, WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
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Articles

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Wendy A. KIMBER, Maria DEAK, Alan R. PRESCOTT, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2003) 376 (2): 525–535.
https://doi.org/10.1042/bj20031154
Published: 01 December 2003
View article titled, Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1
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Articles

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Graham RENA, Alan R. PRESCOTT, Shaodong GUO, Philip COHEN, Terry G. UNTERMAN
Journal: Biochemical Journal
Biochem J (2001) 354 (3): 605–612.
https://doi.org/10.1042/bj3540605
Published: 08 March 2001
View article titled, Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
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Includes: Supplementary data
Articles

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

Karine PEYROLLIER, Eric HAJDUCH, Alexander GRAY, Gary J. LITHERLAND, Alan R. PRESCOTT, Nick R. LESLIE, Harinder S. HUNDAL
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 617–622.
https://doi.org/10.1042/bj3520617
Published: 08 December 2000
View article titled, A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B
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