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Articles

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

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Stephan Wullschleger, David H. Wasserman, Alex Gray, Kei Sakamoto, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2011) 434 (2): 265–274.
https://doi.org/10.1042/BJ20102012
Published: 11 February 2011
View articletitled, Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis
Open the PDF for Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis in another window
Includes: Supplementary data
Articles

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Open Access
Juan M. García-Martínez, Jennifer Moran, Rosemary G. Clarke, Alex Gray, Sabina C. Cosulich, Christine M. Chresta, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2009) 421 (1): 29–42.
https://doi.org/10.1042/BJ20090489
Published: 12 June 2009
View articletitled, Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
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Articles

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

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Ian H. Batty, Jeroen van der Kaay, Alex Gray, Joan F. Telfer, Miles J. Dixon, C. Peter Downes
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 255–266.
https://doi.org/10.1042/BJ20070558
Published: 25 September 2007
View articletitled, The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2
Open the PDF for The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2 in another window
Articles

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

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Ian N. FLEMING, Ian H. BATTY, Alan R. PRESCOTT, Alex GRAY, Gursant S. KULAR, Hazel STEWART, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2004) 382 (3): 857–865.
https://doi.org/10.1042/BJ20040916
Published: 07 September 2004
View articletitled, Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
Open the PDF for Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1 in another window
Articles

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

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Wendy A. KIMBER, Laura TRINKLE-MULCAHY, Peter C. F. CHEUNG, Maria DEAK, Louisa J. MARSDEN, Agnieszka KIELOCH, Stephen WATT, Ronald T. JAVIER, Alex GRAY, C. Peter DOWNES, John M. LUCOCQ, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2002) 361 (3): 525–536.
https://doi.org/10.1042/bj3610525
Published: 25 January 2002
View articletitled, Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo
Open the PDF for Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo in another window
Includes: Multimedia, Supplementary data
Articles

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

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Nick R. LESLIE, Deborah BENNETT, Alex GRAY, Ian PASS, Khe HOANG-XUAN, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2001) 357 (2): 427–435.
https://doi.org/10.1042/bj3570427
Published: 09 July 2001
View articletitled, Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
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Articles

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

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Nick R. LESLIE, Alex GRAY, Ian PASS, Elaine A. ORCHISTON, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 827–833.
https://doi.org/10.1042/bj3460827
Published: 07 March 2000
View articletitled, Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
Open the PDF for Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase in another window
Articles

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Available to Purchase
Richard A. CURRIE, Kay S. WALKER, Alex GRAY, Maria DEAK, Antonio CASAMAYOR, C. Peter DOWNES, Philip COHEN, Dario R. ALESSI, John LUCOCQ
Journal: Biochemical Journal
Biochem J (1999) 337 (3): 575–583.
https://doi.org/10.1042/bj3370575
Published: 25 January 1999
View articletitled, Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
Open the PDF for Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 in another window