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Articles

Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin

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A S Turnell, D P Brant, G R Brown, M Finney, P H Gallimore, C J Kirk, T R V Pagliuca, C J Campbell, R H Michell, R J A Grand
Journal: Biochemical Journal
Biochem J (1995) 308 (3): 965–973.
https://doi.org/10.1042/bj3080965
Published: 15 June 1995
View articletitled, Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin
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Articles

Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells

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C J Barker, P J French, A J Moore, T Nilsson, P O Berggren, C M Bunce, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1995) 306 (2): 557–564.
https://doi.org/10.1042/bj3060557
Published: 01 March 1995
View articletitled, Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells
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Articles

The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells

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J A Stuart, K L Anderson, P J French, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1994) 303 (2): 517–525.
https://doi.org/10.1042/bj3030517
Published: 15 October 1994
View articletitled, The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells
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Articles

Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5) P 3 /Ins(1,3,4,5) P 4 5-phosphomonoesterases

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M Hodgkin, A Craxton, J B Parry, P J Hughes, B V Potter, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1994) 297 (3): 637–645.
https://doi.org/10.1042/bj2970637
Published: 01 February 1994
View articletitled, Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5) P 3 /Ins(1,3,4,5) P 4 5-phosphomonoesterases
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Articles

Simultaneous oscillations of cytoplasmic free Ca 2+ concentration and Ins(1,4,5) P 3 concentration in mouse pancreatic β -cells

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C J Barker, T Nilsson, C J Kirk, R H Michell, P O Berggren
Journal: Biochemical Journal
Biochem J (1994) 297 (2): 265–268.
https://doi.org/10.1042/bj2970265
Published: 15 January 1994
View articletitled, Simultaneous oscillations of cytoplasmic free Ca 2+ concentration and Ins(1,4,5) P 3 concentration in mouse pancreatic β -cells
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Articles

The inositol phosphates in WRK1 rat mammary tumour cells

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N S Wong, C J Barker, A J Morris, A Craxton, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1992) 286 (2): 459–468.
https://doi.org/10.1042/bj2860459
Published: 01 September 1992
View articletitled, The inositol phosphates in WRK1 rat mammary tumour cells
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Articles

The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells

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C J Barker, N S Wong, S M Maccallum, P A Hunt, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1992) 286 (2): 469–474.
https://doi.org/10.1042/bj2860469
Published: 01 September 1992
View articletitled, The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells
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Articles

The opening of the inositol 1,4,5-trisphosphate-sensitive Ca 2+ channel in rat cerebellum is inhibited by caffeine

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G R Brown, L G Sayers, C J Kirk, R H Michell, F Michelangeli
Journal: Biochemical Journal
Biochem J (1992) 282 (2): 309–312.
https://doi.org/10.1042/bj2820309
Published: 01 March 1992
View articletitled, The opening of the inositol 1,4,5-trisphosphate-sensitive Ca 2+ channel in rat cerebellum is inhibited by caffeine
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Articles

Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function

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J Howl, T Ismail, A J Strain, C J Kirk, D Anderson, M Wheatley
Journal: Biochemical Journal
Biochem J (1991) 276 (1): 189–195.
https://doi.org/10.1042/bj2760189
Published: 15 May 1991
View articletitled, Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function
Open the PDF for Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function in another window
Articles

Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells

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G Guillon, M N Balestre, C Lombard, F Rassendren, C J Kirk
Journal: Biochemical Journal
Biochem J (1989) 260 (3): 665–672.
https://doi.org/10.1042/bj2600665
Published: 15 June 1989
View articletitled, Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells
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Articles

Preferential localization of rat liver d-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and ‘late’ endosomal vesicles

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S B Shears, W H Evans, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 256 (2): 363–369.
https://doi.org/10.1042/bj2560363
Published: 01 December 1988
View articletitled, Preferential localization of rat liver d-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and ‘late’ endosomal vesicles
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Articles

Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells

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N S Wong, C J Barker, S B Shears, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 252 (1): 1–5.
https://doi.org/10.1042/bj2520001
Published: 15 May 1988
View articletitled, Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells
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Articles

The pathway of myo -inositol 1,3,4-trisphosphate dephosphorylation in liver

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S B Shears, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1987) 248 (3): 977–980.
https://doi.org/10.1042/bj2480977
Published: 15 December 1987
View articletitled, The pathway of myo -inositol 1,3,4-trisphosphate dephosphorylation in liver
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Articles

Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

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S B Shears, J B Parry, E K Tang, R F Irvine, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1987) 246 (1): 139–147.
https://doi.org/10.1042/bj2460139
Published: 15 August 1987
View articletitled, Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate
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Articles

Dephosphorylation of myo -inositol 1,4,5-trisphosphate and myo -inositol 1,3,4-triphosphate

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S B Shears, D J Storey, A J Morris, A B Cubitt, J B Parry, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1987) 242 (2): 393–402.
https://doi.org/10.1042/bj2420393
Published: 01 March 1987
View articletitled, Dephosphorylation of myo -inositol 1,4,5-trisphosphate and myo -inositol 1,3,4-triphosphate
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Articles

Stimulation, by vasopressin and other agonists, of inositol-lipid breakdown and inositol phosphate accumulation in WRK 1 cells

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C J Kirk, G Guillon, M N Balestre, S Jard
Journal: Biochemical Journal
Biochem J (1986) 240 (1): 197–204.
https://doi.org/10.1042/bj2400197
Published: 15 November 1986
View articletitled, Stimulation, by vasopressin and other agonists, of inositol-lipid breakdown and inositol phosphate accumulation in WRK 1 cells
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Articles

Characterization of specific V 1a vasopressin-binding sites on a rat mammary-tumour-cell line

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G Guillon, C J Kirk, M N Balestre
Journal: Biochemical Journal
Biochem J (1986) 240 (1): 189–196.
https://doi.org/10.1042/bj2400189
Published: 15 November 1986
View articletitled, Characterization of specific V 1a vasopressin-binding sites on a rat mammary-tumour-cell line
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Articles

The labelling of polyphosphoinositides with [ 32 P]P i and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes

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S Palmer, P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 491–499.
https://doi.org/10.1042/bj2380491
Published: 01 September 1986
View articletitled, The labelling of polyphosphoinositides with [ 32 P]P i and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes
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Articles

Changes in free cytosolic calcium and accumulation of inositol phosphates in isolated hepatocytes by [Leu]enkephalin

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R P Leach, S B Shears, C J Kirk, M A Titheradge
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 537–542.
https://doi.org/10.1042/bj2380537
Published: 01 September 1986
View articletitled, Changes in free cytosolic calcium and accumulation of inositol phosphates in isolated hepatocytes by [Leu]enkephalin
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Articles

Ca 2+ transport and Ca 2+ -dependent ATP hydrolysis by Golgi vesicles from lactating rat mammary glands

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S S Virk, C J Kirk, S B Shears
Journal: Biochemical Journal
Biochem J (1985) 226 (3): 741–748.
https://doi.org/10.1042/bj2260741
Published: 15 March 1985
View articletitled, Ca 2+ transport and Ca 2+ -dependent ATP hydrolysis by Golgi vesicles from lactating rat mammary glands
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Articles

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V 1 -vasopressin and muscarinic cholinergic stimuli

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E A Bone, P Fretten, S Palmer, C J Kirk, R H Michell
Journal: Biochemical Journal
Biochem J (1984) 221 (3): 803–811.
https://doi.org/10.1042/bj2210803
Published: 01 August 1984
View articletitled, Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V 1 -vasopressin and muscarinic cholinergic stimuli
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Articles

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular fractionation technique. Vasopressin stimulates mitochondrial Ca2 + uptake

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S B Shears, C J Kirk
Journal: Biochemical Journal
Biochem J (1984) 220 (2): 417–421.
https://doi.org/10.1042/bj2200417
Published: 01 June 1984
View articletitled, Determination of mitochondrial calcium content in hepatocytes by a rapid cellular fractionation technique. Vasopressin stimulates mitochondrial Ca2 + uptake
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Articles

Characterization of a rapid cellular-fractionation technique for hepatocytes. Application in the measurement of mitochondrial membrane potential in situ

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S B Shears, C J Kirk
Journal: Biochemical Journal
Biochem J (1984) 219 (2): 375–382.
https://doi.org/10.1042/bj2190375
Published: 15 April 1984
View articletitled, Characterization of a rapid cellular-fractionation technique for hepatocytes. Application in the measurement of mitochondrial membrane potential in situ
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Articles

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular-fractionation technique. α-adrenergic agonists do not mobilize mitochondrial Ca 2+

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S B Shears, C J Kirk
Journal: Biochemical Journal
Biochem J (1984) 219 (2): 383–389.
https://doi.org/10.1042/bj2190383
Published: 15 April 1984
View articletitled, Determination of mitochondrial calcium content in hepatocytes by a rapid cellular-fractionation technique. α-adrenergic agonists do not mobilize mitochondrial Ca 2+
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Articles

Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes

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P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1984) 218 (3): 785–793.
https://doi.org/10.1042/bj2180785
Published: 15 March 1984
View articletitled, Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes
Open the PDF for Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32 P-labelled lipids from erythrocytes in another window
Articles

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones

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J A Creba, C P Downes, P T Hawkins, G Brewster, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1983) 212 (3): 733–747.
https://doi.org/10.1042/bj2120733
Published: 15 June 1983
View articletitled, Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones
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Articles

A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32 P-labelled ATP.

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P T Hawkins, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1983) 210 (3): 717–720.
https://doi.org/10.1042/bj2100717
Published: 15 March 1983
View articletitled, A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32 P-labelled ATP.
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Articles

Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown

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R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1981) 198 (1): 247–248.
https://doi.org/10.1042/bj1980247
Published: 15 July 1981
View articletitled, Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown
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Articles

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

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C J Kirk, R H Michell, D A Hems
Journal: Biochemical Journal
Biochem J (1981) 194 (1): 155–165.
https://doi.org/10.1042/bj1940155
Published: 15 January 1981
View articletitled, Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin
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Articles

Stimulation of inorganic-phosphate incorporation into phosphatidylinositol in rat thoracic aorta mediated through V 1 -vasopressin receptors

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A P Takhar, C J Kirk
Journal: Biochemical Journal
Biochem J (1981) 194 (1): 167–172.
https://doi.org/10.1042/bj1940167
Published: 15 January 1981
View articletitled, Stimulation of inorganic-phosphate incorporation into phosphatidylinositol in rat thoracic aorta mediated through V 1 -vasopressin receptors
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Articles

The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytes

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C J Kirk, L M Rodrigues, D A Hems
Journal: Biochemical Journal
Biochem J (1979) 178 (2): 493–496.
https://doi.org/10.1042/bj1780493
Published: 15 February 1979
View articletitled, The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytes
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Articles

Fatty acid synthesis in the perfused liver of adrenalectomized rats

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C J Kirk, T R Verrinder, D A Hems
Journal: Biochemical Journal
Biochem J (1976) 156 (3): 593–602.
https://doi.org/10.1042/bj1560593
Published: 15 June 1976
View articletitled, Fatty acid synthesis in the perfused liver of adrenalectomized rats
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