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Articles

The turkey erythrocyte β -adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein α subunits

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S R James, C Vaziri, T R Walker, G Milligan, C P Downes
Journal: Biochemical Journal
Biochem J (1994) 304 (2): 359–364.
https://doi.org/10.1042/bj3040359
Published: 01 December 1994
View articletitled, The turkey erythrocyte β -adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein α subunits
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Articles

Inositol trisphosphate metabolism in Saccharomyces cerevisiae : identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase

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F Estevez, D Pulford, M J Stark, A N Carter, C P Downes
Journal: Biochemical Journal
Biochem J (1994) 302 (3): 709–716.
https://doi.org/10.1042/bj3020709
Published: 15 September 1994
View articletitled, Inositol trisphosphate metabolism in Saccharomyces cerevisiae : identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase
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Articles

Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

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A N Carter, R Huang, A Sorisky, C P Downes, S E Rittenhouse
Journal: Biochemical Journal
Biochem J (1994) 301 (2): 415–420.
https://doi.org/10.1042/bj3010415
Published: 15 July 1994
View articletitled, Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets
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Articles

Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C

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S R James, R A Demel, C P Downes
Journal: Biochemical Journal
Biochem J (1994) 298 (2): 499–506.
https://doi.org/10.1042/bj2980499
Published: 01 March 1994
View articletitled, Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C
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Articles

The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li + as secondary, selective, consequences of inositol depletion in 1321N1 cells

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I H Batty, C P Downes
Journal: Biochemical Journal
Biochem J (1994) 297 (3): 529–537.
https://doi.org/10.1042/bj2970529
Published: 01 February 1994
View articletitled, The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li + as secondary, selective, consequences of inositol depletion in 1321N1 cells
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Articles

Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes

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C Vaziri, C P Downes, S C Macfarlane
Journal: Biochemical Journal
Biochem J (1993) 294 (3): 793–799.
https://doi.org/10.1042/bj2940793
Published: 15 September 1993
View articletitled, Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes
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Articles

The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells

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I H Batty, A Michie, M Fennel, C P Downes
Journal: Biochemical Journal
Biochem J (1993) 294 (1): 49–55.
https://doi.org/10.1042/bj2940049
Published: 15 August 1993
View articletitled, The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells
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Articles

Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells

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D J Sillence, C P Downes
Journal: Biochemical Journal
Biochem J (1993) 290 (2): 381–387.
https://doi.org/10.1042/bj2900381
Published: 01 March 1993
View articletitled, Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells
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Articles

G-protein-mediated activation of turkey erythrocyte phospholipase C by β -adrenergic and P 2y -purinergic receptors

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C Vaziri, C P Downes
Journal: Biochemical Journal
Biochem J (1992) 284 (3): 917–922.
https://doi.org/10.1042/bj2840917
Published: 15 June 1992
View articletitled, G-protein-mediated activation of turkey erythrocyte phospholipase C by β -adrenergic and P 2y -purinergic receptors
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Articles

Studies of inositol analogues as inhibitors of the phosphoinositide pathway, and incorporation of 2-deoxy-2-fluoro- myo -inositol to give analogues of phosphatidylinositol intermediates

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F McPhee, C P Downes, G Lowe
Journal: Biochemical Journal
Biochem J (1991) 277 (2): 407–412.
https://doi.org/10.1042/bj2770407
Published: 15 July 1991
View articletitled, Studies of inositol analogues as inhibitors of the phosphoinositide pathway, and incorporation of 2-deoxy-2-fluoro- myo -inositol to give analogues of phosphatidylinositol intermediates
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Articles

Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes

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F McPhee, G Lowe, C Vaziri, C P Downes
Journal: Biochemical Journal
Biochem J (1991) 275 (1): 187–192.
https://doi.org/10.1042/bj2750187
Published: 01 April 1991
View articletitled, Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes
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Articles

Ca 2(+) -stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets

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W G King, C P Downes, G D Prestwich, S E Rittenhouse
Journal: Biochemical Journal
Biochem J (1990) 270 (1): 125–131.
https://doi.org/10.1042/bj2700125
Published: 15 August 1990
View articletitled, Ca 2(+) -stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets
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Articles

Product-precursor relationships amongst inositol polyphosphates. Incorporation of [ 32 P]P i into myo -inositol 1,3,4,6-tetrakisphosphate, myo -inositol 1,3,4,5-tetrakisphosphate, myo -inositol 3,4,5,6-tetrakisphosphate and myo -inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes

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L R Stephens, C P Downes
Journal: Biochemical Journal
Biochem J (1990) 265 (2): 435–452.
https://doi.org/10.1042/bj2650435
Published: 15 January 1990
View articletitled, Product-precursor relationships amongst inositol polyphosphates. Incorporation of [ 32 P]P i into myo -inositol 1,3,4,6-tetrakisphosphate, myo -inositol 1,3,4,5-tetrakisphosphate, myo -inositol 3,4,5,6-tetrakisphosphate and myo -inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes
Open the PDF for Product-precursor relationships amongst inositol polyphosphates. Incorporation of [ 32 P]P i into myo -inositol 1,3,4,6-tetrakisphosphate, myo -inositol 1,3,4,5-tetrakisphosphate, myo -inositol 3,4,5,6-tetrakisphosphate and myo -inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes in another window
Articles

Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na + /H + antiport. Evidence for two distinct roles for Na + /H + antiport activation

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S J Vallance, C P Downes, E J Cragoe, A D Whetton
Journal: Biochemical Journal
Biochem J (1990) 265 (2): 359–364.
https://doi.org/10.1042/bj2650359
Published: 15 January 1990
View articletitled, Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na + /H + antiport. Evidence for two distinct roles for Na + /H + antiport activation
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Articles

An analysis of myo -[ 3 H]inositol trisphosphates found in myo -[ 3 H]inositol prelabelled avian erythrocytes

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L R Stephens, P T Hawkins, C P Downes
Journal: Biochemical Journal
Biochem J (1989) 262 (3): 727–737.
https://doi.org/10.1042/bj2620727
Published: 15 September 1989
View articletitled, An analysis of myo -[ 3 H]inositol trisphosphates found in myo -[ 3 H]inositol prelabelled avian erythrocytes
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Articles

Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: d-phosphatidyl-myo-inositol 3-phosphate

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L Stephens, P T Hawkins, C P Downes
Journal: Biochemical Journal
Biochem J (1989) 259 (1): 267–276.
https://doi.org/10.1042/bj2590267
Published: 01 April 1989
View articletitled, Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: d-phosphatidyl-myo-inositol 3-phosphate
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Articles

Dephosphorylation of 1d-myo-inositol 1,4-bisphosphate in rat liver

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A J Morris, D J Storey, C P Downes, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 254 (3): 655–660.
https://doi.org/10.1042/bj2540655
Published: 15 September 1988
View articletitled, Dephosphorylation of 1d-myo-inositol 1,4-bisphosphate in rat liver
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Articles

Synthesis of myo -inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

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L R Stephens, P T Hawkins, C J Barker, C P Downes
Journal: Biochemical Journal
Biochem J (1988) 253 (3): 721–733.
https://doi.org/10.1042/bj2530721
Published: 01 August 1988
View articletitled, Synthesis of myo -inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation
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Articles

Phosphoinositide hydrolysis by guanosine 5′-[ γ -thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes

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T K Harden, P T Hawkins, L Stephens, J L Boyer, C P Downes
Journal: Biochemical Journal
Biochem J (1988) 252 (2): 583–593.
https://doi.org/10.1042/bj2520583
Published: 01 June 1988
View articletitled, Phosphoinositide hydrolysis by guanosine 5′-[ γ -thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes
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Articles

Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase

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A J Morris, K J Murray, P J England, C P Downes, R H Michell
Journal: Biochemical Journal
Biochem J (1988) 251 (1): 157–163.
https://doi.org/10.1042/bj2510157
Published: 01 April 1988
View articletitled, Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase
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Articles

Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages

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S J Huang, P N Monk, C P Downes, A D Whetton
Journal: Biochemical Journal
Biochem J (1988) 249 (3): 839–845.
https://doi.org/10.1042/bj2490839
Published: 01 February 1988
View articletitled, Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages
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Articles

Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca 2+ in the presence of calmodulin

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A J Morris, C P Downes, T K Harden, R H Michell
Journal: Biochemical Journal
Biochem J (1987) 248 (2): 489–493.
https://doi.org/10.1042/bj2480489
Published: 01 December 1987
View articletitled, Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca 2+ in the presence of calmodulin
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Articles

Inositol 1,2-cyclic 4,5-trisphosphate is not a product of μscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands

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P T Hawkins, C P Berrie, A J Morris, C P Downes
Journal: Biochemical Journal
Biochem J (1987) 243 (1): 211–218.
https://doi.org/10.1042/bj2430211
Published: 01 April 1987
View articletitled, Inositol 1,2-cyclic 4,5-trisphosphate is not a product of μscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands
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Articles

Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

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C P Downes, P T Hawkins, R F Irvine
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 501–506.
https://doi.org/10.1042/bj2380501
Published: 01 September 1986
View articletitled, Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland
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Articles

Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate

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P T Hawkins, L Stephens, C P Downes
Journal: Biochemical Journal
Biochem J (1986) 238 (2): 507–516.
https://doi.org/10.1042/bj2380507
Published: 01 September 1986
View articletitled, Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate
Open the PDF for Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate in another window
Articles

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

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C P Downes, M A Stone
Journal: Biochemical Journal
Biochem J (1986) 234 (1): 199–204.
https://doi.org/10.1042/bj2340199
Published: 15 February 1986
View articletitled, Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland
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Articles

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

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R F Irvine, E E Anggård, A J Letcher, C P Downes
Journal: Biochemical Journal
Biochem J (1985) 229 (2): 505–511.
https://doi.org/10.1042/bj2290505
Published: 15 July 1985
View articletitled, Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands
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Articles

Inositol trisphosphates in carbachol-stimulated rat parotid glands

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R F Irvine, A J Letcher, D J Lander, C P Downes
Journal: Biochemical Journal
Biochem J (1984) 223 (1): 237–243.
https://doi.org/10.1042/bj2230237
Published: 01 October 1984
View articletitled, Inositol trisphosphates in carbachol-stimulated rat parotid glands
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Articles

Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands

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C P Downes, M M Wusteman
Journal: Biochemical Journal
Biochem J (1983) 216 (3): 633–640.
https://doi.org/10.1042/bj2160633
Published: 15 December 1983
View articletitled, Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands
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Articles

Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands

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C P Downes, M D Dibner, M R Hanley
Journal: Biochemical Journal
Biochem J (1983) 214 (3): 865–870.
https://doi.org/10.1042/bj2140865
Published: 15 September 1983
View articletitled, Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands
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Articles

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones

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J A Creba, C P Downes, P T Hawkins, G Brewster, R H Michell, C J Kirk
Journal: Biochemical Journal
Biochem J (1983) 212 (3): 733–747.
https://doi.org/10.1042/bj2120733
Published: 15 June 1983
View articletitled, Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca 2+ -mobilizing hormones
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Articles

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

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M J Berridge, R M C Dawson, C P Downes, J P Heslop, R F Irvine
Journal: Biochemical Journal
Biochem J (1983) 212 (2): 473–482.
https://doi.org/10.1042/bj2120473
Published: 15 May 1983
View articletitled, Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
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Articles

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

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M J Berridge, C P Downes, M R Hanley
Journal: Biochemical Journal
Biochem J (1982) 206 (3): 587–595.
https://doi.org/10.1042/bj2060587
Published: 15 September 1982
View articletitled, Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
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Articles

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

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C P Downes, M C Mussat, R H Michell
Journal: Biochemical Journal
Biochem J (1982) 203 (1): 169–177.
https://doi.org/10.1042/bj2030169
Published: 01 April 1982
View articletitled, The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
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