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Christopher J. Schofield
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Articles

Photoaffinity labelling displacement assay using multiple recombinant protein domains

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In Collection
Awards
David J. Fallon, Alex Phillipou, Christopher J. Schofield, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Journal: Biochemical Journal
Biochem J (2023) 480 (15): 1183–1197.
https://doi.org/10.1042/BCJ20230129
Published: 31 August 2023
View articletitled, Photoaffinity labelling displacement assay using multiple recombinant protein domains
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Includes: Supplementary data
Articles

The oxygenase Jmjd6–a case study in conflicting assignments

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Angelika Böttger, Md. Saiful Islam, Rasheduzzaman Chowdhury, Christopher J. Schofield, Alexander Wolf
Journal: Biochemical Journal
Biochem J (2015) 468 (2): 191–202.
https://doi.org/10.1042/BJ20150278
Published: 22 May 2015
View articletitled, The oxygenase Jmjd6–a case study in conflicting assignments
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Articles

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

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Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield, Emily Flashman
Journal: Biochemical Journal
Biochem J (2014) 463 (3): 363–372.
https://doi.org/10.1042/BJ20140779
Published: 10 October 2014
View articletitled, Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
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Includes: Supplementary data
Articles

The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization

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Alexander Wolf, Monica Mantri, Astrid Heim, Udo Müller, Erika Fichter, Mukram M. Mackeen, Lothar Schermelleh, Gregory Dadie, Heinrich Leonhardt, Catherine Vénien-Bryan, Benedikt M. Kessler, Christopher J. Schofield, Angelika Böttger
Journal: Biochemical Journal
Biochem J (2013) 453 (3): 357–370.
https://doi.org/10.1042/BJ20130529
Published: 12 July 2013
View articletitled, The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization
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Includes: Supplementary data
Articles

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

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Elena M. Sánchez-Fernández, Hanna Tarhonskaya, Khalid Al-Qahtani, Richard J. Hopkinson, James S. O. McCullagh, Christopher J. Schofield, Emily Flashman
Journal: Biochemical Journal
Biochem J (2013) 449 (2): 491–496.
https://doi.org/10.1042/BJ20121155
Published: 14 December 2012
View articletitled, Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase
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Includes: Supplementary data
Articles

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

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Emily Flashman, Sarah L. Davies, Kar Kheng Yeoh, Christopher J. Schofield
Journal: Biochemical Journal
Biochem J (2010) 427 (1): 135–142.
https://doi.org/10.1042/BJ20091609
Published: 15 March 2010
View articletitled, Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
Open the PDF for Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents in another window
Includes: Supplementary data
Articles

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

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Patrick J. Pollard, Christoph Loenarz, David R. Mole, Michael A. McDonough, Jonathan M. Gleadle, Christopher J. Schofield, Peter J. Ratcliffe
Journal: Biochemical Journal
Biochem J (2008) 416 (3): 387–394.
https://doi.org/10.1042/BJ20081238
Published: 26 November 2008
View articletitled, Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
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Includes: Supplementary data
Articles

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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Dominic Ehrismann, Emily Flashman, David N. Genn, Nicolas Mathioudakis, Kirsty S. Hewitson, Peter J. Ratcliffe, Christopher J. Schofield
Journal: Biochemical Journal
Biochem J (2007) 401 (1): 227–234.
https://doi.org/10.1042/BJ20061151
Published: 11 December 2006
View articletitled, Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
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Articles

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

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Jonathan M. ELKINS, Nadia J. KERSHAW, Christopher J. SCHOFIELD
Journal: Biochemical Journal
Biochem J (2005) 385 (2): 565–573.
https://doi.org/10.1042/BJ20040814
Published: 07 January 2005
View articletitled, X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster
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Articles

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

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David E. LANCASTER, Luke A. McNEILL, Michael A. McDONOUGH, Robin T. APLIN, Kirsty S. HEWITSON, Christopher W. PUGH, Peter J. RATCLIFFE, Christopher J. SCHOFIELD
Journal: Biochemical Journal
Biochem J (2004) 383 (3): 429–437.
https://doi.org/10.1042/BJ20040735
Published: 26 October 2004
View articletitled, Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
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Includes: Supplementary data
Articles

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

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Alexandra J. LONG, Ian J. CLIFTON, Peter L. ROACH, Jack E. BALDWIN, Christopher J. SCHOFIELD, Peter J. RUTLEDGE
Journal: Biochemical Journal
Biochem J (2003) 372 (3): 687–693.
https://doi.org/10.1042/bj20021627
Published: 15 June 2003
View articletitled, Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate
Open the PDF for Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate in another window
Articles

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

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Luke A. McNEILL, Kirsty S. HEWITSON, Timothy D. CLARIDGE, Jürgen F. SEIBEL, Louise E. HORSFALL, Christopher J. SCHOFIELD
Journal: Biochemical Journal
Biochem J (2002) 367 (3): 571–575.
https://doi.org/10.1042/bj20021162
Published: 01 November 2002
View articletitled, Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803
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Articles

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis

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Jonathan M. ELKINS, Ian. J. CLIFTON, Helena HERNÁNDEZ, Linh X. DOAN, Carol V. ROBINSON, Christopher J. SCHOFIELD, Kirsty S. HEWITSON
Journal: Biochemical Journal
Biochem J (2002) 366 (2): 423–434.
https://doi.org/10.1042/bj20020125
Published: 01 September 2002
View articletitled, Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis
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Articles

‘pH-jump’ crystallographic analyses of γ-lactam–porcine pancreatic elastase complexes

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Penny A. WRIGHT, Rupert C. WILMOUTH, Ian J. CLIFTON, Christopher J. SCHOFIELD
Journal: Biochemical Journal
Biochem J (2000) 351 (2): 335–340.
https://doi.org/10.1042/bj3510335
Published: 10 October 2000
View articletitled, ‘pH-jump’ crystallographic analyses of γ-lactam–porcine pancreatic elastase complexes
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Articles

Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis

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Christopher C. LAWRENCE, Wendy J. SOBEY, Robert A. FIELD, Jack E. BALDWIN, Christopher J. SCHOFIELD
Journal: Biochemical Journal
Biochem J (1996) 313 (1): 185–191.
https://doi.org/10.1042/bj3130185
Published: 01 January 1996
View articletitled, Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis
Open the PDF for Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis in another window