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Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

In Collection

Dominic P. Byrne, Safal Shrestha, Leonard A. Daly, Vanessa Marensi, Krithika Ramakrishnan, Claire E. Eyers, Natarajan Kannan, Patrick A. Eyers

Biochem J (2023) 480 (2): 141–160.

https://doi.org/10.1042/BCJ20220474

Published: 23 January 2023

View article titled, Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Includes: Multimedia, Supplementary data

Articles

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins

Biochem J (2022) 479 (19): 2131–2151.

https://doi.org/10.1042/BCJ20220103

Published: 14 October 2022

View article titled, Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Includes: Supplementary data

Articles

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Biochem J (2022) 479 (19): 2087–2113.

https://doi.org/10.1042/BCJ20220089

Published: 14 October 2022

View article titled, Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Includes: Supplementary data

Articles

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Biochem J (2022) 479 (19): 2063–2086.

https://doi.org/10.1042/BCJ20220102

Published: 14 October 2022

View article titled, Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Includes: Supplementary data

Articles

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

Richard Campion, Leanne Bloxam, Kimberley Burrow, Philip J. Brownridge, Daniel R. Pentland, Patricia Thomas, Campbell W. Gourlay, Claire E. Eyers, Jeff W. Barclay, Alan Morgan

Biochem J (2021) 478 (24): 4153–4167.

https://doi.org/10.1042/BCJ20210432

Published: 16 December 2021

View article titled, Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

Includes: Supplementary data

Articles

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

Amy E. Campbell, Catarina Ferraz Franco, Ling-I Su, Emma K. Corbin, Simon Perkins, Anton Kalyuzhnyy, Andrew R. Jones, Philip J. Brownridge, Neil D. Perkins, Claire E. Eyers

Biochem J (2021) 478 (3): 533–551.

https://doi.org/10.1042/BCJ20200627

Published: 10 February 2021

View article titled, Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

Includes: Supplementary data

Articles

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Dominic P. Byrne, Christopher J. Clarke, Philip J. Brownridge, Anton Kalyuzhnyy, Simon Perkins, Amy Campbell, David Mason, Andrew R. Jones, Patrick A. Eyers, Claire E. Eyers

Biochem J (2020) 477 (13): 2451–2475.

https://doi.org/10.1042/BCJ20200309

Published: 02 July 2020

View article titled, Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Includes: Supplementary data

Articles

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2435–2455.

https://doi.org/10.1042/BCJ20180266

Published: 14 August 2018

View article titled, New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Includes: Supplementary data

Articles

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2417–2433.

https://doi.org/10.1042/BCJ20180265

Published: 14 August 2018

View article titled, New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Includes: Supplementary data

Articles

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

Dominic P. Byrne, Matthias Vonderach, Samantha Ferries, Philip J. Brownridge, Claire E. Eyers, Patrick A. Eyers

Biochem J (2016) 473 (19): 3159–3175.

https://doi.org/10.1042/BCJ20160648

Published: 27 September 2016

View article titled, cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

Includes: Supplementary data

Articles

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Fiona P. Bailey, Dominic P. Byrne, Krishnadev Oruganty, Claire E. Eyers, Christopher J. Novotny, Kevan M. Shokat, Natarajan Kannan, Patrick A. Eyers

Biochem J (2015) 467 (1): 47–62.

https://doi.org/10.1042/BJ20141441

Published: 20 March 2015

View article titled, The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Includes: Supplementary data

Articles

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

Claire E. EYERS, Helen McNEILL, Axel KNEBEL, Nick MORRICE, Simon J. C. ARTHUR, Ana CUENDA, Philip COHEN

Biochem J (2005) 389 (1): 127–135.

https://doi.org/10.1042/BJ20050387

Published: 21 June 2005

View article titled, The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

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Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

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