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D. Grahame HARDIE
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Articles

The pro-drug C13 activates AMPK by two distinct mechanisms

Open Access
Jordana B. Freemantle, Dinesh Shah, Dylan M. Lynch, Alessio Ciulli, Harinder S. Hundal, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2024) 481 (18): 1203–1219.
https://doi.org/10.1042/BCJ20240425
Published: 12 September 2024
View articletitled, The pro-drug C13 activates AMPK by two distinct mechanisms
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Includes: Supplementary data
Articles

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Open Access
Simon A. Hawley, Fiona M. Russell, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2024) 481 (8): 587–599.
https://doi.org/10.1042/BCJ20240082
Published: 22 April 2024
View articletitled, AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand
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Includes: Supplementary data
Articles

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Open Access
Fiona A. Ross, Simon A. Hawley, Fiona M. Russell, Nicola Goodman, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2023) 480 (23): 1951–1968.
https://doi.org/10.1042/BCJ20230380
Published: 01 December 2023
View articletitled, Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers
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Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Open Access
In Collection
Awards
D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2022) 479 (22): 2327–2343.
https://doi.org/10.1042/BCJ20220255
Published: 16 November 2022
View articletitled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets
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Articles

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Open Access
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Elaine C. Thomas, Sharon C. Hook, Alexander Gray, Alexandra Chadt, David Carling, Hadi Al-Hasani, Kate J. Heesom, D. Grahame Hardie, Jeremy M. Tavaré
Journal: Biochemical Journal
Biochem J (2018) 475 (18): 2969–2983.
https://doi.org/10.1042/BCJ20180475
Published: 25 September 2018
View articletitled, Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
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Includes: Supplementary data
Articles

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

Open Access
Fiona A. Ross, Thomas E. Jensen, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2016) 473 (2): 189–199.
https://doi.org/10.1042/BJ20150910
Published: 05 January 2016
View articletitled, Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
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Articles

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Available to Purchase
Thomas E. Jensen, Fiona A. Ross, Maximilian Kleinert, Lykke Sylow, Jonas R. Knudsen, Graeme J. Gowans, D. Grahame Hardie, Erik A. Richter
Journal: Biochemical Journal
Biochem J (2015) 467 (3): 461–472.
https://doi.org/10.1042/BJ20141142
Published: 17 April 2015
View articletitled, PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain
Open the PDF for PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain in another window
Articles

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Open Access
Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2014) 459 (2): 275–287.
https://doi.org/10.1042/BJ20131344
Published: 28 March 2014
View articletitled, Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
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Includes: Supplementary data
Articles

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Available to Purchase
Charlotte J. Green, Katherine Macrae, Sarah Fogarty, D. Grahame Hardie, Kei Sakamoto, Harinder S. Hundal
Journal: Biochemical Journal
Biochem J (2011) 435 (2): 463–474.
https://doi.org/10.1042/BJ20101517
Published: 29 March 2011
View articletitled, Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase
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Includes: Supplementary data
Articles

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Open Access
Sarah Fogarty, Simon A. Hawley, Kevin A. Green, Nazan Saner, Kirsty J. Mustard, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2010) 426 (1): 109–118.
https://doi.org/10.1042/BJ20091372
Published: 27 January 2010
View articletitled, Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP
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Articles

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Available to Purchase
Mhairi C. Towler, Sarah Fogarty, Simon A. Hawley, David A. Pan, David M. A. Martin, Nicolas A. Morrice, Afshan McCarthy, María N. Galardo, Silvina B. Meroni, Selva B. Cigorraga, Alan Ashworth, Kei Sakamoto, D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2008) 416 (1): 1–14.
https://doi.org/10.1042/BJ20081447
Published: 28 October 2008
View articletitled, A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
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Includes: Supplementary data
Articles

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

Available to Purchase
Kathryn M. Geraghty, Shuai Chen, Jean E. Harthill, Adel F. Ibrahim, Rachel Toth, Nick A. Morrice, Franck Vandermoere, Greg B. Moorhead, D. Grahame Hardie, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 231–241.
https://doi.org/10.1042/BJ20070649
Published: 25 September 2007
View articletitled, Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
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Includes: Supplementary data
Articles

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

Available to Purchase
David A. PAN, D. Grahame HARDIE
Journal: Biochemical Journal
Biochem J (2002) 367 (1): 179–186.
https://doi.org/10.1042/bj20020703
Published: 01 October 2002
View articletitled, A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion
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Articles

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

Available to Purchase
Peter C. F. CHEUNG, Ian P. SALT, Stephen P. DAVIES, D. Grahame HARDIE, David CARLING
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 659–669.
https://doi.org/10.1042/bj3460659
Published: 07 March 2000
View articletitled, Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
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Articles

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

Available to Purchase
D. Grahame HARDIE, Ian P. SALT, Simon A. HAWLEY, Stephen P. DAVIES
Journal: Biochemical Journal
Biochem J (1999) 338 (3): 717–722.
https://doi.org/10.1042/bj3380717
Published: 08 March 1999
View articletitled, AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge
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Articles

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

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Ian P. SALT, Gabriele JOHNSON, Stephen J. H. ASHCROFT, D. Grahame HARDIE
Journal: Biochemical Journal
Biochem J (1998) 335 (3): 533–539.
https://doi.org/10.1042/bj3350533
Published: 01 November 1998
View articletitled, AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
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Articles

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Available to Purchase
Ian SALT, Jakub W. CELLER, Simon A. HAWLEY, Alan PRESCOTT, Angela WOODS, David CARLING, D. Grahame HARDIE
Journal: Biochemical Journal
Biochem J (1998) 334 (1): 177–187.
https://doi.org/10.1042/bj3340177
Published: 15 August 1998
View articletitled, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
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Articles

Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3′:5′-cyclic monophosphate

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D. Grahame Hardie, David A. Stansfield
Journal: Biochemical Journal
Biochem J (1977) 164 (1): 213–221.
https://doi.org/10.1042/bj1640213
Published: 15 April 1977
View articletitled, Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3′:5′-cyclic monophosphate
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