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Articles

The pro-drug C13 activates AMPK by two distinct mechanisms

Jordana B. Freemantle, Dinesh Shah, Dylan M. Lynch, Alessio Ciulli, Harinder S. Hundal, D. Grahame Hardie

Biochem J (2024) 481 (18): 1203–1219.

https://doi.org/10.1042/BCJ20240425

Published: 12 September 2024

View article titled, The pro-drug C13 activates AMPK by two distinct mechanisms

Includes: Supplementary data

Articles

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Simon A. Hawley, Fiona M. Russell, D. Grahame Hardie

Biochem J (2024) 481 (8): 587–599.

https://doi.org/10.1042/BCJ20240082

Published: 22 April 2024

View article titled, AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Includes: Supplementary data

Articles

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Fiona A. Ross, Simon A. Hawley, Fiona M. Russell, Nicola Goodman, D. Grahame Hardie

Biochem J (2023) 480 (23): 1951–1968.

https://doi.org/10.1042/BCJ20230380

Published: 01 December 2023

View article titled, Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Elaine C. Thomas, Sharon C. Hook, Alexander Gray, Alexandra Chadt, David Carling, Hadi Al-Hasani, Kate J. Heesom, D. Grahame Hardie, Jeremy M. Tavaré

Biochem J (2018) 475 (18): 2969–2983.

https://doi.org/10.1042/BCJ20180475

Published: 25 September 2018

View article titled, Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Includes: Supplementary data

Articles

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

Fiona A. Ross, Thomas E. Jensen, D. Grahame Hardie

Biochem J (2016) 473 (2): 189–199.

https://doi.org/10.1042/BJ20150910

Published: 05 January 2016

View article titled, Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

Articles

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Thomas E. Jensen, Fiona A. Ross, Maximilian Kleinert, Lykke Sylow, Jonas R. Knudsen, Graeme J. Gowans, D. Grahame Hardie, Erik A. Richter

Biochem J (2015) 467 (3): 461–472.

https://doi.org/10.1042/BJ20141142

Published: 17 April 2015

View article titled, PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Articles

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie, D. Grahame Hardie

Biochem J (2014) 459 (2): 275–287.

https://doi.org/10.1042/BJ20131344

Published: 28 March 2014

View article titled, Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Includes: Supplementary data

Articles

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Charlotte J. Green, Katherine Macrae, Sarah Fogarty, D. Grahame Hardie, Kei Sakamoto, Harinder S. Hundal

Biochem J (2011) 435 (2): 463–474.

https://doi.org/10.1042/BJ20101517

Published: 29 March 2011

View article titled, Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Includes: Supplementary data

Articles

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Sarah Fogarty, Simon A. Hawley, Kevin A. Green, Nazan Saner, Kirsty J. Mustard, D. Grahame Hardie

Biochem J (2010) 426 (1): 109–118.

https://doi.org/10.1042/BJ20091372

Published: 27 January 2010

View article titled, Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

Articles

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Mhairi C. Towler, Sarah Fogarty, Simon A. Hawley, David A. Pan, David M. A. Martin, Nicolas A. Morrice, Afshan McCarthy, María N. Galardo, Silvina B. Meroni, Selva B. Cigorraga, Alan Ashworth, Kei Sakamoto, D. Grahame Hardie

Biochem J (2008) 416 (1): 1–14.

https://doi.org/10.1042/BJ20081447

Published: 28 October 2008

View article titled, A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Includes: Supplementary data

Articles

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

Kathryn M. Geraghty, Shuai Chen, Jean E. Harthill, Adel F. Ibrahim, Rachel Toth, Nick A. Morrice, Franck Vandermoere, Greg B. Moorhead, D. Grahame Hardie, Carol MacKintosh

Biochem J (2007) 407 (2): 231–241.

https://doi.org/10.1042/BJ20070649

Published: 25 September 2007

View article titled, Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

Includes: Supplementary data

Articles

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

David A. PAN, D. Grahame HARDIE

Biochem J (2002) 367 (1): 179–186.

https://doi.org/10.1042/bj20020703

Published: 01 October 2002

View article titled, A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

Articles

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

Peter C. F. CHEUNG, Ian P. SALT, Stephen P. DAVIES, D. Grahame HARDIE, David CARLING

Biochem J (2000) 346 (3): 659–669.

https://doi.org/10.1042/bj3460659

Published: 07 March 2000

View article titled, Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

Articles

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

D. Grahame HARDIE, Ian P. SALT, Simon A. HAWLEY, Stephen P. DAVIES

Biochem J (1999) 338 (3): 717–722.

https://doi.org/10.1042/bj3380717

Published: 08 March 1999

View article titled, AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

Articles

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

Ian P. SALT, Gabriele JOHNSON, Stephen J. H. ASHCROFT, D. Grahame HARDIE

Biochem J (1998) 335 (3): 533–539.

https://doi.org/10.1042/bj3350533

Published: 01 November 1998

View article titled, AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

Articles

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Ian SALT, Jakub W. CELLER, Simon A. HAWLEY, Alan PRESCOTT, Angela WOODS, David CARLING, D. Grahame HARDIE

Biochem J (1998) 334 (1): 177–187.

https://doi.org/10.1042/bj3340177

Published: 15 August 1998

View article titled, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Articles

Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3′:5′-cyclic monophosphate

D. Grahame Hardie, David A. Stansfield

Biochem J (1977) 164 (1): 213–221.

https://doi.org/10.1042/bj1640213

Published: 15 April 1977

View article titled, Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3′:5′-cyclic monophosphate

NARROW

The pro-drug C13 activates AMPK by two distinct mechanisms

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca 2+ and AMP

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3′:5′-cyclic monophosphate

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