Page 1 | Search Results | Biochemical Journal

1-50 of 70

Sort by

Sort Order Select

Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi

Biochem J (2022) 479 (18): 1941–1965.

https://doi.org/10.1042/BCJ20220308

Published: 23 September 2022

View articletitled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Articles

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi

Biochem J (2022) 479 (17): 1759–1783.

https://doi.org/10.1042/BCJ20220161

Published: 06 September 2022

View articletitled, Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Includes: Supplementary data

Articles

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Zhuoyao Chen, Jinwei Zhang, Adrián R. Murillo-de-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E. Manning, Fiona J. Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock

Biochem J (2022) 479 (5): 661–675.

https://doi.org/10.1042/BCJ20220019

Published: 04 March 2022

View articletitled, Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Includes: Supplementary data

Articles

Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Anna Tasegian, Francois Singh, Ian G. Ganley, Alastair D. Reith, Dario R. Alessi

Biochem J (2021) 478 (19): 3555–3573.

https://doi.org/10.1042/BCJ20210375

Published: 06 October 2021

View articletitled, Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Includes: Supplementary data

Articles

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

In Collection

Protein structure and function

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi

Biochem J (2021) 478 (3): 553–578.

https://doi.org/10.1042/BCJ20200937

Published: 10 February 2021

View articletitled, Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Includes: Supplementary data

Articles

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Raja S. Nirujogi, Francesca Tonelli, Matthew Taylor, Pawel Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi

Biochem J (2021) 478 (2): 299–326.

https://doi.org/10.1042/BCJ20200930

Published: 22 January 2021

View articletitled, Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Includes: Supplementary data

Articles

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

Alexia F. Kalogeropulou, Jordana B. Freemantle, Pawel Lis, Edmundo G. Vides, Nicole K. Polinski, Dario R. Alessi

Biochem J (2020) 477 (22): 4397–4423.

https://doi.org/10.1042/BCJ20200458

Published: 27 November 2020

View articletitled, Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

Includes: Supplementary data

Articles

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Nazma Malik, Raja S. Nirujogi, Julien Peltier, Thomas Macartney, Melanie Wightman, Alan R. Prescott, Robert Gourlay, Matthias Trost, Dario R. Alessi, Athanasios Karapetsas

Biochem J (2019) 476 (20): 3081–3107.

https://doi.org/10.1042/BCJ20190608

Published: 30 October 2019

View articletitled, Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Includes: Supplementary data

Articles

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Rafeeq Mir, Francesca Tonelli, Pawel Lis, Thomas Macartney, Nicole K. Polinski, Terina N. Martinez, Meng-Yun Chou, Andrew J.M. Howden, Theresa König, Christoph Hotzy, Ivan Milenkovic, Thomas Brücke, Alexander Zimprich, Esther Sammler, Dario R. Alessi

Biochem J (2018) 475 (11): 1861–1883.

https://doi.org/10.1042/BCJ20180248

Published: 06 June 2018

View articletitled, The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

Includes: Supplementary data

Articles

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

Nazma Malik, Thomas Macartney, Annika Hornberger, Karen E. Anderson, Hannah Tovell, Alan R. Prescott, Dario R. Alessi

Biochem J (2018) 475 (1): 117–135.

https://doi.org/10.1042/BCJ20170650

Published: 02 January 2018

View articletitled, Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

Includes: Supplementary data

Articles

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi

Biochem J (2018) 475 (1): 1–22.

https://doi.org/10.1042/BCJ20170802

Published: 02 January 2018

View articletitled, Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Includes: Supplementary data

Articles

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Ying Fan, Andrew J.M. Howden, Adil R. Sarhan, Pawel Lis, Genta Ito, Terina N. Martinez, Kathrin Brockmann, Thomas Gasser, Dario R. Alessi, Esther M. Sammler

Biochem J (2018) 475 (1): 23–44.

https://doi.org/10.1042/BCJ20170803

Published: 02 January 2018

View articletitled, Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Includes: Supplementary data

Articles

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi

Biochem J (2016) 473 (17): 2671–2685.

https://doi.org/10.1042/BCJ20160557

Published: 30 August 2016

View articletitled, Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Includes: Supplementary data

Articles

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley, Dario R. Alessi

Biochem J (2014) 463 (3): 413–427.

https://doi.org/10.1042/BJ20140889

Published: 10 October 2014

View articletitled, Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Includes: Supplementary data

Articles

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Sourav Banerjee, Anna Zagórska, Maria Deak, David G. Campbell, Alan R. Prescott, Dario R. Alessi

Biochem J (2014) 461 (2): 233–245.

https://doi.org/10.1042/BJ20140408

Published: 26 June 2014

View articletitled, Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Includes: Supplementary data

Articles

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Jenny van der Wijst, Maxime G. Blanchard, Helen I. Woodroof, Thomas J. Macartney, Robert Gourlay, Joost G. Hoenderop, René J. Bindels, Dario R. Alessi

Biochem J (2014) 460 (2): 165–175.

https://doi.org/10.1042/BJ20131639

Published: 13 May 2014

View articletitled, Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Includes: Supplementary data

Articles

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

Frances-Rose Schumacher, Fiona J. Sorrell, Dario R. Alessi, Alex N. Bullock, Thimo Kurz

Biochem J (2014) 460 (2): 237–246.

https://doi.org/10.1042/BJ20140153

Published: 13 May 2014

View articletitled, Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

Includes: Supplementary data

Articles

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G. Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R. Alessi, Axel Knebel, Matthias Trost, Miratul M. K. Muqit

Biochem J (2014) 460 (1): 127–141.

https://doi.org/10.1042/BJ20140334

Published: 25 April 2014

View articletitled, Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Includes: Supplementary data

Articles

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Paola de los Heros, Dario R. Alessi, Robert Gourlay, David G. Campbell, Maria Deak, Thomas J. Macartney, Kristopher T. Kahle, Jinwei Zhang

Biochem J (2014) 458 (3): 559–573.

https://doi.org/10.1042/BJ20131478

Published: 28 February 2014

View articletitled, The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Articles

Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Vanessa P. Houde, Maria Stella Ritorto, Robert Gourlay, Joby Varghese, Paul Davies, Natalia Shpiro, Kei Sakamoto, Dario R. Alessi

Biochem J (2014) 458 (1): 41–56.

https://doi.org/10.1042/BJ20131324

Published: 20 January 2014

View articletitled, Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Includes: Supplementary data

Articles

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Sourav Banerjee, Sara J. Buhrlage, Hai-Tsang Huang, Xianming Deng, Wenjun Zhou, Jinhua Wang, Ryan Traynor, Alan R. Prescott, Dario R. Alessi, Nathanael S. Gray

Biochem J (2014) 457 (1): 215–225.

https://doi.org/10.1042/BJ20131152

Published: 10 December 2013

View articletitled, Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Includes: Multimedia, Supplementary data

Articles

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Paul Davies, Kelly M. Hinkle, Nour N. Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R. Alessi, Thomas G. Beach, Deanna L. Benson, Charles L. White, III, Rita M. Cowell, Sonal S. Das, Andrew B. West, Heather L. Melrose

Biochem J (2013) 453 (1): 101–113.

https://doi.org/10.1042/BJ20121742

Published: 13 June 2013

View articletitled, Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Includes: Supplementary data

Articles

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Eeva M. Sommer, Hannah Dry, Darren Cross, Sylvie Guichard, Barry R. Davies, Dario R. Alessi

Biochem J (2013) 452 (3): 499–508.

https://doi.org/10.1042/BJ20130342

Published: 31 May 2013

View articletitled, Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Includes: Supplementary data

Articles

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances-Rose Schumacher, Youcef Mehellou, Clare Johnson, Axel Knebel, Thomas J. Macartney, Nicola T. Wood, Dario R. Alessi, Thimo Kurz

Biochem J (2013) 451 (1): 111–122.

https://doi.org/10.1042/BJ20121903

Published: 14 March 2013

View articletitled, The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Includes: Supplementary data

Articles

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors

Ayaz Najafov, Natalia Shpiro, Dario R. Alessi

Biochem J (2012) 448 (2): 285–295.

https://doi.org/10.1042/BJ20121287

Published: 07 November 2012

View articletitled, Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors

Includes: Supplementary data

Articles

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Jacob O. Thastrup, Fatema H. Rafiqi, Alberto C. Vitari, Eulalia Pozo-Guisado, Maria Deak, Youcef Mehellou, Dario R. Alessi

Biochem J (2012) 441 (1): 325–337.

https://doi.org/10.1042/BJ20111879

Published: 14 December 2011

View articletitled, SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Includes: Supplementary data

Articles

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Michale Bouskila, Noor Esoof, Laurie Gay, Emily H. Fang, Maria Deak, Michael J. Begley, Lewis C. Cantley, Alan Prescott, Kate G. Storey, Dario R. Alessi

Biochem J (2011) 437 (1): 157–167.

https://doi.org/10.1042/BJ20110276

Published: 14 June 2011

View articletitled, TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Includes: Supplementary data

Articles

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Laura R. Pearce, Eeva M. Sommer, Kei Sakamoto, Stephan Wullschleger, Dario R. Alessi

Biochem J (2011) 436 (1): 169–179.

https://doi.org/10.1042/BJ20102103

Published: 27 April 2011

View articletitled, Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Includes: Supplementary data

Articles

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Stephan Wullschleger, David H. Wasserman, Alex Gray, Kei Sakamoto, Dario R. Alessi

Biochem J (2011) 434 (2): 265–274.

https://doi.org/10.1042/BJ20102012

Published: 11 February 2011

View articletitled, Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Includes: Supplementary data

Articles

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Ayaz Najafov, Eeva M. Sommer, Jeffrey M. Axten, M. Phillip Deyoung, Dario R. Alessi

Biochem J (2011) 433 (2): 357–369.

https://doi.org/10.1042/BJ20101732

Published: 22 December 2010

View articletitled, Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Articles

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Laura R. Pearce, Gordon R. Alton, Daniel T. Richter, John C. Kath, Laura Lingardo, Justin Chapman, Catherine Hwang, Dario R. Alessi

Biochem J (2010) 431 (2): 245–255.

https://doi.org/10.1042/BJ20101024

Published: 28 September 2010

View articletitled, Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Includes: Supplementary data

Articles

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Nicolas Dzamko, Maria Deak, Faycal Hentati, Alastair D. Reith, Alan R. Prescott, Dario R. Alessi, R. Jeremy Nichols

Biochem J (2010) 430 (3): 405–413.

https://doi.org/10.1042/BJ20100784

Published: 27 August 2010

View articletitled, Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Includes: Supplementary data

Articles

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi

Biochem J (2010) 430 (3): 393–404.

https://doi.org/10.1042/BJ20100483

Published: 27 August 2010

View articletitled, 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Includes: Supplementary data

Articles

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

R. Jeremy Nichols, Nicolas Dzamko, Jessica E. Hutti, Lewis C. Cantley, Maria Deak, Jennifer Moran, Paul Bamborough, Alastair D. Reith, Dario R. Alessi

Biochem J (2009) 424 (1): 47–60.

https://doi.org/10.1042/BJ20091035

Published: 23 October 2009

View articletitled, Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

Includes: Supplementary data

Articles

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Juan M. García-Martínez, Jennifer Moran, Rosemary G. Clarke, Alex Gray, Sabina C. Cosulich, Christine M. Chresta, Dario R. Alessi

Biochem J (2009) 421 (1): 29–42.

https://doi.org/10.1042/BJ20090489

Published: 12 June 2009

View articletitled, Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Articles

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

Christian Peifer, Dario R. Alessi

Biochem J (2009) 417 (1): e5–e7.

https://doi.org/10.1042/BJ20082243

Published: 12 December 2008

View articletitled, New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

Articles

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Juan M. García-Martínez, Dario R. Alessi

Biochem J (2008) 416 (3): 375–385.

https://doi.org/10.1042/BJ20081668

Published: 26 November 2008

View articletitled, mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Articles

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Xu Huang, Stephan Wullschleger, Natalia Shpiro, Victoria A. McGuire, Kei Sakamoto, Yvonne L. Woods, Wendy Mcburnie, Stewart Fleming, Dario R. Alessi

Biochem J (2008) 412 (2): 211–221.

https://doi.org/10.1042/BJ20080557

Published: 14 May 2008

View articletitled, Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Includes: Supplementary data

Articles

Control of AMPK-related kinases by USP9X and atypical Lys 29 /Lys 33 -linked polyubiquitin chains

Abdallah K. Al-Hakim, Anna Zagorska, Louise Chapman, Maria Deak, Mark Peggie, Dario R. Alessi

Biochem J (2008) 411 (2): 249–260.

https://doi.org/10.1042/BJ20080067

Published: 27 March 2008

View articletitled, Control of AMPK-related kinases by USP9X and atypical Lys 29 /Lys 33 -linked polyubiquitin chains

Includes: Supplementary data

Articles

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott, Natalia Shpiro, C. James Hastie, Hilary Mclauchlan, Iva Klevernic, J. Simon C. Arthur, Dario R. Alessi, Philip Cohen

Biochem J (2007) 408 (3): 297–315.

https://doi.org/10.1042/BJ20070797

Published: 28 November 2007

View articletitled, The selectivity of protein kinase inhibitors: a further update

Includes: Supplementary data

Articles

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Laura R. Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F. M. Ibrahim, Robert Gourlay, Mark A. Magnuson, Dario R. Alessi

Biochem J (2007) 405 (3): 513–522.

https://doi.org/10.1042/BJ20070540

Published: 13 July 2007

View articletitled, Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Includes: Supplementary data

Articles

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Mahaboobi Jaleel, R. Jeremy Nichols, Maria Deak, David G. Campbell, Frank Gillardon, Axel Knebel, Dario R. Alessi

Biochem J (2007) 405 (2): 307–317.

https://doi.org/10.1042/BJ20070209

Published: 27 June 2007

View articletitled, LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Includes: Supplementary data

Articles

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Gopal P. Sapkota, Lorna Cummings, Felicity S. Newell, Christopher Armstrong, Jennifer Bain, Morten Frodin, Matthias Grauert, Matthias Hoffmann, Gisela Schnapp, Martin Steegmaier, Philip Cohen, Dario R. Alessi

Biochem J (2007) 401 (1): 29–38.

https://doi.org/10.1042/BJ20061088

Published: 11 December 2006

View articletitled, BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Includes: Supplementary data

Articles

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Alberto C. Vitari, Jacob Thastrup, Fatema H. Rafiqi, Maria Deak, Nick A. Morrice, Håkan K. R. Karlsson, Dario R. Alessi

Biochem J (2006) 397 (1): 223–231.

https://doi.org/10.1042/BJ20060220

Published: 14 June 2006

View articletitled, Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Articles

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Mahaboobi Jaleel, Fabrizio Villa, Maria Deak, Rachel Toth, Alan R. Prescott, Daan M. F. van Aalten, Dario R. Alessi

Biochem J (2006) 394 (3): 545–555.

https://doi.org/10.1042/BJ20051844

Published: 24 February 2006

View articletitled, The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Articles

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

Christopher Lipina, Xu Huang, David Finlay, Edward J McManus, Dario R. Alessi, Calum Sutherland

Biochem J (2005) 392 (3): 633–639.

https://doi.org/10.1042/BJ20051046

Published: 06 December 2005

View articletitled, Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

Articles

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Alberto C. Vitari, Maria Deak, Nick A. Morrice, Dario R. Alessi

Biochem J (2005) 391 (1): 17–24.

https://doi.org/10.1042/BJ20051180

Published: 26 September 2005

View articletitled, The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Includes: Supplementary data

Articles

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Alfonso MORA, Christopher LIPINA, François TRONCHE, Calum SUTHERLAND, Dario R. ALESSI

Biochem J (2005) 385 (3): 639–648.

https://doi.org/10.1042/BJ20041782

Published: 24 January 2005

View articletitled, Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Articles

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Alberto C. VITARI, Maria DEAK, Barry J. COLLINS, Nick MORRICE, Alan R. PRESCOTT, Anne PHELAN, Sian HUMPHREYS, Dario R. ALESSI

Biochem J (2004) 378 (1): 257–268.

https://doi.org/10.1042/bj20031692

Published: 15 February 2004

View articletitled, WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Articles

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Wendy A. KIMBER, Maria DEAK, Alan R. PRESCOTT, Dario R. ALESSI

Biochem J (2003) 376 (2): 525–535.

https://doi.org/10.1042/bj20031154

Published: 01 December 2003

View articletitled, Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only