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David G. Campbell
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Articles

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Open Access
Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2022) 479 (16): 1709–1725.
https://doi.org/10.1042/BCJ20220184
Published: 31 August 2022
View articletitled, Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
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Includes: Supplementary data
Articles

Assembly and structure of Lys 33 -linked polyubiquitin reveals distinct conformations

Open Access
Yosua Adi Kristariyanto, Soo-Youn Choi, Syed Arif Abdul Rehman, Maria Stella Ritorto, David G Campbell, Nicholas A Morrice, Rachel Toth, Yogesh Kulathu
Journal: Biochemical Journal
Biochem J (2015) 467 (2): 345–352.
https://doi.org/10.1042/BJ20141502
Published: 02 April 2015
View articletitled, Assembly and structure of Lys 33 -linked polyubiquitin reveals distinct conformations
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Includes: Supplementary data
Articles

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase

Open Access
Sourav Banerjee, Anna Zagórska, Maria Deak, David G. Campbell, Alan R. Prescott, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2014) 461 (2): 233–245.
https://doi.org/10.1042/BJ20140408
Published: 26 June 2014
View articletitled, Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β MYPT1 phosphatase complex and the SCF βTrCP E3 ubiquitin ligase
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Includes: Supplementary data
Articles

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Open Access
Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G. Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R. Alessi, Axel Knebel, Matthias Trost, Miratul M. K. Muqit
Journal: Biochemical Journal
Biochem J (2014) 460 (1): 127–141.
https://doi.org/10.1042/BJ20140334
Published: 25 April 2014
View articletitled, Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65
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Includes: Supplementary data
Articles

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Open Access
Paola de los Heros, Dario R. Alessi, Robert Gourlay, David G. Campbell, Maria Deak, Thomas J. Macartney, Kristopher T. Kahle, Jinwei Zhang
Journal: Biochemical Journal
Biochem J (2014) 458 (3): 559–573.
https://doi.org/10.1042/BJ20131478
Published: 28 February 2014
View articletitled, The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters
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Articles

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Open Access
Sam Strickson, David G. Campbell, Christoph H. Emmerich, Axel Knebel, Lorna Plater, Maria Stella Ritorto, Natalia Shpiro, Philip Cohen
Journal: Biochemical Journal
Biochem J (2013) 451 (3): 427–437.
https://doi.org/10.1042/BJ20121651
Published: 12 April 2013
View articletitled, The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system
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Includes: Supplementary data
Articles

ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

Open Access
Kumara Dissanayake, Rachel Toth, Jamie Blakey, Olof Olsson, David G. Campbell, Alan R. Prescott, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2011) 433 (3): 515–525.
https://doi.org/10.1042/BJ20101562
Published: 14 January 2011
View articletitled, ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa
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Includes: Supplementary data
Articles

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Open Access
R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2010) 430 (3): 393–404.
https://doi.org/10.1042/BJ20100483
Published: 27 August 2010
View articletitled, 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
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Includes: Supplementary data
Articles

Bioinformatic and experimental survey of 14-3-3-binding sites

Open Access
Catherine Johnson, Sandra Crowther, Margaret J. Stafford, David G. Campbell, Rachel Toth, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2010) 427 (1): 69–78.
https://doi.org/10.1042/BJ20091834
Published: 15 March 2010
View articletitled, Bioinformatic and experimental survey of 14-3-3-binding sites
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Includes: Supplementary data
Articles

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

Available to Purchase
Heidi Mendoza, David G. Campbell, Kerry Burness, James Hastie, Natalia Ronkina, Jae-Hyuck Shim, J. Simon C. Arthur, Roger J. Davis, Matthias Gaestel, Gary L. Johnson, Sankar Ghosh, Philip Cohen
Journal: Biochemical Journal
Biochem J (2008) 409 (3): 711–722.
https://doi.org/10.1042/BJ20071149
Published: 15 January 2008
View articletitled, Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex
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Articles

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Available to Purchase
Shuai Chen, Jane Murphy, Rachel Toth, David G. Campbell, Nick A. Morrice, Carol Mackintosh
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 449–459.
https://doi.org/10.1042/BJ20071114
Published: 21 December 2007
View articletitled, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
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Includes: Supplementary data
Articles

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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Mahaboobi Jaleel, R. Jeremy Nichols, Maria Deak, David G. Campbell, Frank Gillardon, Axel Knebel, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2007) 405 (2): 307–317.
https://doi.org/10.1042/BJ20070209
Published: 27 June 2007
View articletitled, LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
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Includes: Supplementary data
Articles

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

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Claire E. Mccoy, Andrew Macdonald, Nick A. Morrice, David G. Campbell, Maria Deak, Rachel Toth, Joanne Mcilrath, J. Simon C. Arthur
Journal: Biochemical Journal
Biochem J (2007) 402 (3): 491–501.
https://doi.org/10.1042/BJ20061183
Published: 26 February 2007
View articletitled, Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
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Articles

Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ

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Simon Morton, Huei-Ting Yang, Ntsane Moleleki, David G. Campbell, Philip Cohen, Simon Rousseau
Journal: Biochemical Journal
Biochem J (2006) 399 (2): 265–273.
https://doi.org/10.1042/BJ20060681
Published: 27 September 2006
View articletitled, Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ
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Articles

Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation

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Andrew D. Wingate, David G. Campbell, Mark Peggie, J. Simon C. Arthur
Journal: Biochemical Journal
Biochem J (2006) 393 (3): 715–724.
https://doi.org/10.1042/BJ20050967
Published: 13 January 2006
View articletitled, Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation
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Includes: Supplementary data
Articles

Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser 428

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Mercedes Pozuelo Rubio, David G. Campbell, Nicholas A. Morrice, Carol Mackintosh
Journal: Biochemical Journal
Biochem J (2005) 392 (1): 163–172.
https://doi.org/10.1042/BJ20051103
Published: 08 November 2005
View articletitled, Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser 428
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Includes: Supplementary data
Articles

Nogo-B is a new physiological substrate for MAPKAP-K2

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Simon Rousseau, Mark Peggie, David G. Campbell, Angel R. Nebreda, Philip Cohen
Journal: Biochemical Journal
Biochem J (2005) 391 (2): 433–440.
https://doi.org/10.1042/BJ20050935
Published: 10 October 2005
View articletitled, Nogo-B is a new physiological substrate for MAPKAP-K2
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Articles

Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL

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Gillian C. Auld, David G. Campbell, Nick Morrice, Philip Cohen
Journal: Biochemical Journal
Biochem J (2005) 389 (3): 775–783.
https://doi.org/10.1042/BJ20050733
Published: 26 July 2005
View articletitled, Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL
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Articles

MSK1 activity is controlled by multiple phosphorylation sites

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Claire E. McCOY, David G. CAMPBELL, Maria DEAK, Graham B. BLOOMBERG, J. Simon C. ARTHUR
Journal: Biochemical Journal
Biochem J (2005) 387 (2): 507–517.
https://doi.org/10.1042/BJ20041501
Published: 05 April 2005
View articletitled, MSK1 activity is controlled by multiple phosphorylation sites
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Includes: Supplementary data
Articles

Identification of filamin C as a new physiological substrate of PKBα using KESTREL

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James T. MURRAY, David G. CAMPBELL, Mark PEGGIE, Mora ALFONSO, Philip COHEN
Journal: Biochemical Journal
Biochem J (2004) 384 (3): 489–494.
https://doi.org/10.1042/BJ20041058
Published: 07 December 2004
View articletitled, Identification of filamin C as a new physiological substrate of PKBα using KESTREL
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Articles

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

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James T. MURRAY, David G. CAMPBELL, Nicholas MORRICE, Gillian C. AULD, Natalia SHPIRO, Rodolpho MARQUEZ, Mark PEGGIE, Jenny BAIN, Graham B. BLOOMBERG, Florian GRAHAMMER, Florian LANG, Peer WULFF, Dietmar KUHL, Philip COHEN
Journal: Biochemical Journal
Biochem J (2004) 384 (3): 477–488.
https://doi.org/10.1042/BJ20041057
Published: 07 December 2004
View articletitled, Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3
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Articles

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

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Mercedes POZUELO RUBIO, Kathryn M. GERAGHTY, Barry H. C. WONG, Nicola T. WOOD, David G. CAMPBELL, Nick MORRICE, Carol MACKINTOSH
Journal: Biochemical Journal
Biochem J (2004) 379 (2): 395–408.
https://doi.org/10.1042/bj20031797
Published: 15 April 2004
View articletitled, 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
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Articles

Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta

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Yvonne KUMA, David G. CAMPBELL, Ana CUENDA
Journal: Biochemical Journal
Biochem J (2004) 379 (1): 133–139.
https://doi.org/10.1042/bj20031559
Published: 01 April 2004
View articletitled, Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta
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Articles

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

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Nimesh MODY, David G. CAMPBELL, Nick MORRICE, Mark PEGGIE, Philip COHEN
Journal: Biochemical Journal
Biochem J (2003) 372 (2): 567–575.
https://doi.org/10.1042/bj20030193
Published: 01 June 2003
View articletitled, An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro
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Articles

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

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Simon DOWLER, Richard A. CURRIE, David G. CAMPBELL, Maria DEAK, Gursant KULAR, C. Peter DOWNES, Dario R. ALESSI
Journal: Biochemical Journal
Biochem J (2000) 351 (1): 19–31.
https://doi.org/10.1042/bj3510019
Published: 26 September 2000
View articletitled, Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities
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