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David Carling
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Articles

AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes

Open Access
Sophia Bustraan, Jane Bennett, Chad Whilding, Betheney R. Pennycook, David Smith, Alexis R. Barr, Jon Read, David Carling, Alice Pollard
Journal: Biochemical Journal
Biochem J (2024) 481 (5): 345–362.
https://doi.org/10.1042/BCJ20240003
Published: 23 February 2024
View articletitled, AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes
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Includes: Supplementary data
Articles

Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495

Available to Purchase
Katrin Spengler, Darya Zibrova, Angela Woods, Christopher G. Langendorf, John W. Scott, David Carling, Regine Heller
Journal: Biochemical Journal
Biochem J (2020) 477 (17): 3453–3469.
https://doi.org/10.1042/BCJ20200555
Published: 17 September 2020
View articletitled, Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
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Includes: Supplementary data
Articles

Thermogenic adipocytes: lineage, function and therapeutic potential

Open Access
In Collection
Adipose biology
Alice E. Pollard, David Carling
Journal: Biochemical Journal
Biochem J (2020) 477 (11): 2071–2093.
https://doi.org/10.1042/BCJ20200298
Published: 15 June 2020
View articletitled, Thermogenic adipocytes: lineage, function and therapeutic potential
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Articles

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Open Access
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Elaine C. Thomas, Sharon C. Hook, Alexander Gray, Alexandra Chadt, David Carling, Hadi Al-Hasani, Kate J. Heesom, D. Grahame Hardie, Jeremy M. Tavaré
Journal: Biochemical Journal
Biochem J (2018) 475 (18): 2969–2983.
https://doi.org/10.1042/BCJ20180475
Published: 25 September 2018
View articletitled, Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
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Includes: Supplementary data
Articles

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Open Access
Robin Willows, Matthew J. Sanders, Bing Xiao, Bhakti R. Patel, Stephen R. Martin, Jon Read, Jon R. Wilson, Julia Hubbard, Steven J. Gamblin, David Carling
Journal: Biochemical Journal
Biochem J (2017) 474 (17): 3059–3073.
https://doi.org/10.1042/BCJ20170458
Published: 22 August 2017
View articletitled, Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells
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Articles

Effect of different γ-subunit isoforms on the regulation of AMPK

Open Access
Robin Willows, Naveenan Navaratnam, Ana Lima, Jon Read, David Carling
Journal: Biochemical Journal
Biochem J (2017) 474 (10): 1741–1754.
https://doi.org/10.1042/BCJ20170046
Published: 09 May 2017
View articletitled, Effect of different γ-subunit isoforms on the regulation of AMPK
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Articles

AMP-activated protein kinase: new regulation, new roles?

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David Carling, Claire Thornton, Angela Woods, Matthew J. Sanders
Journal: Biochemical Journal
Biochem J (2012) 445 (1): 11–27.
https://doi.org/10.1042/BJ20120546
Published: 15 June 2012
View articletitled, AMP-activated protein kinase: new regulation, new roles?
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Articles

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Available to Purchase
Claire Thornton, Nicola J. Bright, Magdalena Sastre, Phillip J. Muckett, David Carling
Journal: Biochemical Journal
Biochem J (2011) 434 (3): 503–512.
https://doi.org/10.1042/BJ20101485
Published: 24 February 2011
View articletitled, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
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Includes: Supplementary data
Articles

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Open Access
Angela Woods, Amanda J. Heslegrave, Phillip J. Muckett, Adam P. Levene, Melanie Clements, Margaret Mobberley, Timothy A. Ryder, Shadi Abu-Hayyeh, Catherine Williamson, Robert D. Goldin, Alan Ashworth, Dominic J. Withers, David Carling
Journal: Biochemical Journal
Biochem J (2011) 434 (1): 49–60.
https://doi.org/10.1042/BJ20101721
Published: 27 January 2011
View articletitled, LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
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Articles

Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

Open Access
Craig Beall, Kaisa Piipari, Hind Al-Qassab, Mark A. Smith, Nadeene Parker, David Carling, Benoit Viollet, Dominic J. Withers, Michael L. J. Ashford
Journal: Biochemical Journal
Biochem J (2010) 429 (2): 323–333.
https://doi.org/10.1042/BJ20100231
Published: 28 June 2010
View articletitled, Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia
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Includes: Supplementary data
Articles

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Available to Purchase
Matthew J. Sanders, Pascal O. Grondin, Bronwyn D. Hegarty, Michael A. Snowden, David Carling
Journal: Biochemical Journal
Biochem J (2007) 403 (1): 139–148.
https://doi.org/10.1042/BJ20061520
Published: 13 March 2007
View articletitled, Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
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Articles

Expression and regulation of the AMP-activated protein kinase–SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits

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Tyrone DANIEL, David CARLING
Journal: Biochemical Journal
Biochem J (2002) 365 (3): 629–638.
https://doi.org/10.1042/bj20020124
Published: 01 August 2002
View articletitled, Expression and regulation of the AMP-activated protein kinase–SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits
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Articles

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

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Lee G.D. FRYER, Fabienne FOUFELLE, Kay BARNES, Stephen A. BALDWIN, Angela WOODS, David CARLING
Journal: Biochemical Journal
Biochem J (2002) 363 (1): 167–174.
https://doi.org/10.1042/bj3630167
Published: 22 March 2002
View articletitled, Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells
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Articles

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

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Peter C. F. CHEUNG, Ian P. SALT, Stephen P. DAVIES, D. Grahame HARDIE, David CARLING
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 659–669.
https://doi.org/10.1042/bj3460659
Published: 07 March 2000
View articletitled, Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
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Articles

The regulation of AMP-activated protein kinase by phosphorylation

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Silvie C. STEIN, Angela WOODS, Neil A. JONES, Matthew D. DAVISON, David CARLING
Journal: Biochemical Journal
Biochem J (2000) 345 (3): 437–443.
https://doi.org/10.1042/bj3450437
Published: 25 January 2000
View articletitled, The regulation of AMP-activated protein kinase by phosphorylation
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Articles

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

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Ian SALT, Jakub W. CELLER, Simon A. HAWLEY, Alan PRESCOTT, Angela WOODS, David CARLING, D. Grahame HARDIE
Journal: Biochemical Journal
Biochem J (1998) 334 (1): 177–187.
https://doi.org/10.1042/bj3340177
Published: 15 August 1998
View articletitled, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
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Articles

Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2Cα

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Anna E. MARLEY, Jane E. SULLIVAN, David CARLING, W. Mark ABBOTT, Graeme J. SMITH, Ian W. F. TAYLOR, Frank CAREY, Raj K. BERI
Journal: Biochemical Journal
Biochem J (1996) 320 (3): 801–806.
https://doi.org/10.1042/bj3200801
Published: 15 December 1996
View articletitled, Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2Cα
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