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David R. Adams
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Articles

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

Open Access
Kirsty F. Houslay, Frank Christian, Ruth MacLeod, David R. Adams, Miles D. Houslay, George S. Baillie
Journal: Biochemical Journal
Biochem J (2017) 474 (4): 597–609.
https://doi.org/10.1042/BCJ20160849
Published: 03 February 2017
View article titled, Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners
Open the PDF for Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners in another window
Articles

Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Available to Purchase
Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexandra Kaupisch, Nicole M. Kane, George S. Baillie, Andrew H. Baker, Graeme Milligan, Miles D. Houslay, Joanne C. Mountford
Journal: Biochemical Journal
Biochem J (2010) 432 (3): 575–599.
https://doi.org/10.1042/BJ20100726
Published: 25 November 2010
View article titled, Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells
Open the PDF for Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells in another window
Includes: Supplementary data
Articles

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Available to Purchase
Paul D. Andrews, Melissa Becroft, Anders Aspegren, Jane Gilmour, Martyn J. James, Scott McRae, Robert Kime, Robert W. Allcock, Achamma Abraham, Zhong Jiang, Raimund Strehl, Joanne C. Mountford, Graeme Milligan, Miles D. Houslay, David R. Adams, Julie A. Frearson
Journal: Biochemical Journal
Biochem J (2010) 432 (1): 21–35.
https://doi.org/10.1042/BJ20101022
Published: 25 October 2010
View article titled, High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules
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Includes: Supplementary data
Articles

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

Available to Purchase
Xiang Li, Suryakiran Vadrevu, Allan Dunlop, Jon Day, Noopur Advant, Jessica Troeger, Enno Klussmann, Ellis Jaffrey, Ron T. Hay, David R. Adams, Miles D. Houslay, George S. Baillie
Journal: Biochemical Journal
Biochem J (2010) 428 (1): 55–65.
https://doi.org/10.1042/BJ20091672
Published: 28 April 2010
View article titled, Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK
Open the PDF for Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK in another window
Articles

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs

Available to Purchase
Tian-Rui Xu, George S. Baillie, Narinder Bhari, Thomas M. Houslay, Andrew M. Pitt, David R. Adams, Walter Kolch, Miles D. Houslay, Graeme Milligan
Journal: Biochemical Journal
Biochem J (2008) 413 (1): 51–60.
https://doi.org/10.1042/BJ20080685
Published: 12 June 2008
View article titled, Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs
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Articles

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

Available to Purchase
George S. Baillie, David R. Adams, Narinder Bhari, Thomas M. Houslay, Suryakiran Vadrevu, Dong Meng, Xiang Li, Allan Dunlop, Graeme Milligan, Graeme B. Bolger, Enno Klussmann, Miles D. Houslay
Journal: Biochemical Journal
Biochem J (2007) 404 (1): 71–80.
https://doi.org/10.1042/BJ20070005
Published: 26 April 2007
View article titled, Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays
Open the PDF for Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays in another window
Articles

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

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Graeme B. Bolger, George S. Baillie, Xiang Li, Martin J. Lynch, Pawel Herzyk, Ahmed Mohamed, Lisa High Mitchell, Angela McCahill, Christian Hundsrucker, Enno Klussmann, David R. Adams, Miles D. Houslay
Journal: Biochemical Journal
Biochem J (2006) 398 (1): 23–36.
https://doi.org/10.1042/BJ20060423
Published: 27 July 2006
View article titled, Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
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Articles

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

Available to Purchase
Lee Ann JOHNSTON, Suat ERDOGAN, York Fong CHEUNG, Michael SULLIVAN, Rachael BARBER, Martin J. LYNCH, George S. BAILLIE, Gino VAN HEEKE, David R. ADAMS, Elaine HUSTON, Miles D. HOUSLAY
Journal: Biochemical Journal
Biochem J (2004) 380 (2): 371–384.
https://doi.org/10.1042/bj20031662
Published: 01 June 2004
View article titled, Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene
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Articles

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

Available to Purchase
Miles D. HOUSLAY, David R. ADAMS
Journal: Biochemical Journal
Biochem J (2003) 370 (1): 1–18.
https://doi.org/10.1042/bj20021698
Published: 15 February 2003
View article titled, PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
Open the PDF for PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization in another window