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Articles

Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress

Alaa Droubi, Simon J. Bulley, Jonathan H. Clarke, Robin F. Irvine

Biochem J (2016) 473 (14): 2155–2163.

https://doi.org/10.1042/BCJ20160380

Published: 12 July 2016

View article titled, Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress

Includes: Supplementary data

Articles

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Jonathan H. Clarke, Maria-Luisa Giudici, John E. Burke, Roger L. Williams, David J. Maloney, Juan Marugan, Robin F. Irvine

Biochem J (2015) 466 (2): 359–367.

https://doi.org/10.1042/BJ20141333

Published: 20 February 2015

View article titled, The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Includes: Supplementary data

Articles

Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

Jonathan H. Clarke, Robin F. Irvine

Biochem J (2013) 454 (1): 49–57.

https://doi.org/10.1042/BJ20130488

Published: 26 July 2013

View article titled, Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

Includes: Supplementary data

Articles

Genomic tagging reveals a random association of endogenous PtdIns5 P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform

Minchuan Wang, Nicholas J. Bond, Andrew J. Letcher, Jonathan P. Richardson, Kathryn S. Lilley, Robin F. Irvine, Jonathan H. Clarke

Biochem J (2010) 430 (2): 215–221.

https://doi.org/10.1042/BJ20100340

Published: 13 August 2010

View article titled, Genomic tagging reveals a random association of endogenous PtdIns5 P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform

Includes: Supplementary data

Articles

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4 P and PtdIns(4,5) P 2

Gerald R. V. Hammond, Giampietro Schiavo, Robin F. Irvine

Biochem J (2009) 422 (1): 23–35.

https://doi.org/10.1042/BJ20090428

Published: 29 July 2009

View article titled, Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4 P and PtdIns(4,5) P 2

Includes: Multimedia, Supplementary data

Articles

Do mammals make all their own inositol hexakisphosphate?

Andrew J. Letcher, Michael J. Schell, Robin F. Irvine

Biochem J (2008) 416 (2): 263–270.

https://doi.org/10.1042/BJ20081417

Published: 12 November 2008

View article titled, Do mammals make all their own inositol hexakisphosphate?

Articles

Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis

Jowie C. H. Yu, Samantha M. Lloyd-Burton, Robin F. Irvine, Michael J. Schell

Biochem J (2005) 392 (3): 435–441.

https://doi.org/10.1042/BJ20050829

Published: 06 December 2005

View article titled, Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis

Articles

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility

David Brough, Michael J. Schell, Robin F. Irvine

Biochem J (2005) 392 (2): 291–297.

https://doi.org/10.1042/BJ20050738

Published: 22 November 2005

View article titled, Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility

Articles

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

Maria-Luisa GIUDICI, Piers C. EMSON, Robin F. IRVINE

Biochem J (2004) 379 (2): 489–496.

https://doi.org/10.1042/bj20031394

Published: 15 April 2004

View article titled, A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma

Articles

Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores

Alan P. DAWSON, Edward J.A. LEA, Robin F. IRVINE

Biochem J (2003) 370 (2): 621–629.

https://doi.org/10.1042/bj20021289

Published: 01 March 2003

View article titled, Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores

Articles

Type IIα phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms

Katherine A. HINCHLIFFE, Maria Luisa GIUDICI, Andrew J. LETCHER, Robin F. IRVINE

Biochem J (2002) 363 (3): 563–570.

https://doi.org/10.1042/bj3630563

Published: 24 April 2002

View article titled, Type IIα phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms

Articles

Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells

Jonathan H. CLARKE, Andrew J. LETCHER, Clive S. D'SANTOS, Jonathan R. HALSTEAD, Robin F. IRVINE, Nullin DIVECHA

Biochem J (2001) 357 (3): 905–910.

https://doi.org/10.1042/bj3570905

Published: 25 July 2001

View article titled, Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells

Articles

The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells

Peter M. SMITH, Alexander R. HARMER, Andrew J. LETCHER, Robin F. IRVINE

Biochem J (2000) 347 (1): 77–82.

https://doi.org/10.1042/bj3470077

Published: 27 March 2000

View article titled, The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells

Articles

Nuclear targeting of the β isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7

Antonio CIRUELA, Katherine A. HINCHLIFFE, Nullin DIVECHA, Robin F. IRVINE

Biochem J (2000) 346 (3): 587–591.

https://doi.org/10.1042/bj3460587

Published: 07 March 2000

View article titled, Nuclear targeting of the β isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7

Articles

Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by Ins(1,3,4,5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor

Jefferson W. LOOMIS-HUSSELBEE, Christopher D. WALKER, Joanna R. BOTTOMLEY, Peter J. CULLEN, Robin F. IRVINE, Alan P. DAWSON

Biochem J (1998) 331 (3): 947–952.

https://doi.org/10.1042/bj3310947

Published: 01 May 1998

View article titled, Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by Ins(1,3,4,5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor

Articles

Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors

Jonathan S. MARCHANT, Young-Tae CHANG, Sung-Kee CHUNG, Robin F. IRVINE, Colin W. TAYLOR

Biochem J (1997) 321 (3): 573–576.

https://doi.org/10.1042/bj3210573

Published: 01 February 1997

View article titled, Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors

Articles

Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca 2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites

Jeff W. LOOMIS-HUSSELBEE, Peter J. CULLEN, Uschi E. DREIKHAUSEN, Robin F. IRVINE, Alan P. DAWSON

Biochem J (1996) 314 (3): 811–816.

https://doi.org/10.1042/bj3140811

Published: 15 March 1996

View article titled, Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca 2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites

Articles

Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells

N Divecha, A J Letcher, H H Banfic, S G Rhee, R F Irvine

Biochem J (1995) 312 (1): 63–67.

https://doi.org/10.1042/bj3120063

Published: 15 November 1995

View article titled, Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells

Articles

The cloning and sequence of the C isoform of PtdIns4 P 5-kinase

N Divecha, O Truong, J J Hsuan, K A Hinchliffe, R F Irvine

Biochem J (1995) 309 (3): 715–719.

https://doi.org/10.1042/bj3090715

Published: 01 August 1995

View article titled, The cloning and sequence of the C isoform of PtdIns4 P 5-kinase

Articles

Purification and characterization of an Ins(1,3,4,5) P 4 binding protein from pig platelets: possible identification of a novel non-neuronal Ins(1,3,4,5) P 4 receptor

P J Cullen, A P Dawson, R F Irvine

Biochem J (1995) 305 (1): 139–143.

https://doi.org/10.1042/bj3050139

Published: 01 January 1995

View article titled, Purification and characterization of an Ins(1,3,4,5) P 4 binding protein from pig platelets: possible identification of a novel non-neuronal Ins(1,3,4,5) P 4 receptor

Articles

Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets

P J Cullen, Y Patel, V V Kakkar, R F Irvine, K S Authi

Biochem J (1994) 298 (3): 739–742.

https://doi.org/10.1042/bj2980739

Published: 15 March 1994

View article titled, Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets

Articles

Rapid turnover of phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos : signs of a phosphatidylinositide 3-kinase signalling pathway in lower plants?

T Munnik, R F Irvine, A Musgrave

Biochem J (1994) 298 (2): 269–273.

https://doi.org/10.1042/bj2980269

Published: 01 March 1994

View article titled, Rapid turnover of phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos : signs of a phosphatidylinositide 3-kinase signalling pathway in lower plants?

Articles

Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo -inositol hexakisphosphate

P T Hawkins, D R Poyner, T R Jackson, A J Letcher, D A Lander, R F Irvine

Biochem J (1993) 294 (3): 929–934.

https://doi.org/10.1042/bj2940929

Published: 15 September 1993

View article titled, Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo -inositol hexakisphosphate

Articles

Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes

F Irvine, A V Wallace, S R Sarawak, M D Houslay

Biochem J (1993) 293 (1): 249–253.

https://doi.org/10.1042/bj2930249

Published: 01 July 1993

View article titled, Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes

Articles

Monoclonal antibodies to phosphatidylinositol 4-phosphate 5-kinase: distribution and intracellular localization of the C isoform

C E L Brooksbank, A Hutchings, G W Butcher, R F Irvine, N Divecha

Biochem J (1993) 291 (1): 77–82.

https://doi.org/10.1042/bj2910077

Published: 01 April 1993

View article titled, Monoclonal antibodies to phosphatidylinositol 4-phosphate 5-kinase: distribution and intracellular localization of the C isoform

Articles

Nuclear diacylglycerol is increased during cell proliferation in vivo

H Banfić, M Žižak, N Divecha, R F Irvine

Biochem J (1993) 290 (3): 633–636.

https://doi.org/10.1042/bj2900633

Published: 15 March 1993

View article titled, Nuclear diacylglycerol is increased during cell proliferation in vivo

Articles

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β 1 is specifically, but not predominantly, located in the nucleus

N Divecha, S G Rhee, A J Letcher, R F Irvine

Biochem J (1993) 289 (3): 617–620.

https://doi.org/10.1042/bj2890617

Published: 01 February 1993

View article titled, Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β 1 is specifically, but not predominantly, located in the nucleus

Articles

Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases

N Divecha, C E L Brooksbank, R F Irvine

Biochem J (1992) 288 (2): 637–642.

https://doi.org/10.1042/bj2880637

Published: 01 December 1992

View article titled, Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases

Articles

Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance

P J Cullen, R F Irvine

Biochem J (1992) 288 (1): 149–154.

https://doi.org/10.1042/bj2880149

Published: 15 November 1992

View article titled, Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance

Articles

Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos

R F Irvine, A J Letcher, L R Stephens, A Musgrave

Biochem J (1992) 281 (1): 261–266.

https://doi.org/10.1042/bj2810261

Published: 01 January 1992

View article titled, Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos

Articles

Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells

J W Loomis-Husselbee, P J Cullen, R F Irvine, A P Dawson

Biochem J (1991) 277 (3): 883–885.

https://doi.org/10.1042/bj2770883

Published: 01 August 1991

View article titled, Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells

Articles

myo -inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo -inositol hexakisphosphate

L R Stephens, P T Hawkins, A F Stanley, T Moore, D R Poyner, P J Morris, M R Hanley, R R Kay, R F Irvine

Biochem J (1991) 275 (2): 485–499.

https://doi.org/10.1042/bj2750485

Published: 15 April 1991

View article titled, myo -inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo -inositol hexakisphosphate

Articles

Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency

I Ivorra, R Gigg, R F Irvine, I Parker

Biochem J (1991) 273 (2): 317–321.

https://doi.org/10.1042/bj2730317

Published: 15 January 1991

View article titled, Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency

Articles

A myo-inositol d-3 hydroxykinase activity in Dictyostelium

L R Stephens, R R Kay, R F Irvine

Biochem J (1990) 272 (1): 201–210.

https://doi.org/10.1042/bj2720201

Published: 15 November 1990

View article titled, A myo-inositol d-3 hydroxykinase activity in Dictyostelium

Articles

Synergistic control of Ca 2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate

P J Cullen, R F Irvine, A P Dawson

Biochem J (1990) 271 (2): 549–553.

https://doi.org/10.1042/bj2710549

Published: 15 October 1990

View article titled, Synergistic control of Ca 2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate

Articles

Agonist-stimulated inositol phosphate metabolism in avian erythrocytes

L R Stephens, C P Berrie, R F Irvine

Biochem J (1990) 269 (1): 65–72.

https://doi.org/10.1042/bj2690065

Published: 01 July 1990

View article titled, Agonist-stimulated inositol phosphate metabolism in avian erythrocytes

Articles

Automated isocratic high-performance liquid chromatography of inositol phosphate isomers

K A Wreggett, R F Irvine

Biochem J (1989) 262 (3): 997–1000.

https://doi.org/10.1042/bj2620997

Published: 15 September 1989

View article titled, Automated isocratic high-performance liquid chromatography of inositol phosphate isomers

Articles

Inositol 1,3,4,5-tetrakisphosphate causes release of Ca 2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate

P J Cullen, R F Irvine, B K Drøbak, A P Dawson

Biochem J (1989) 259 (3): 931–933.

https://doi.org/10.1042/bj2590931

Published: 01 May 1989

View article titled, Inositol 1,3,4,5-tetrakisphosphate causes release of Ca 2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate

Articles

Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors

A L Willcocks, J Strupish, R F Irvine, S R Nahorski

Biochem J (1989) 257 (1): 297–300.

https://doi.org/10.1042/bj2570297

Published: 01 January 1989

View article titled, Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors

Articles

Inositol phosphate production and Ca 2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine

W K Pollock, K A Wreggett, R F Irvine

Biochem J (1988) 256 (2): 371–376.

https://doi.org/10.1042/bj2560371

Published: 01 December 1988

View article titled, Inositol phosphate production and Ca 2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine

Articles

Formation of methylphosphoryl inositol phosphates by extractions that employ methanol

J E Brown, M Rudnick, A J Letcher, R F Irvine

Biochem J (1988) 253 (3): 703–710.

https://doi.org/10.1042/bj2530703

Published: 01 August 1988

View article titled, Formation of methylphosphoryl inositol phosphates by extractions that employ methanol

Articles

Phosphatidylinositol 4,5-bisphosphate phosphodiesterase in higher plants

W C McMurray, R F Irvine

Biochem J (1988) 249 (3): 877–881.

https://doi.org/10.1042/bj2490877

Published: 01 February 1988

View article titled, Phosphatidylinositol 4,5-bisphosphate phosphodiesterase in higher plants

Articles

Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

L Cocco, R S Gilmour, A Ognibene, A J Letcher, F A Manzoli, R F Irvine

Biochem J (1987) 248 (3): 765–770.

https://doi.org/10.1042/bj2480765

Published: 15 December 1987

View article titled, Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

Articles

Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

S B Shears, J B Parry, E K Tang, R F Irvine, R H Michell, C J Kirk

Biochem J (1987) 246 (1): 139–147.

https://doi.org/10.1042/bj2460139

Published: 15 August 1987

View article titled, Metabolism of d-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

Articles

Extraction and recovery of inositol phosphates from tissues

K A Wreggett, L R Howe, J P Moore, R F Irvine

Biochem J (1987) 245 (3): 933–934.

https://doi.org/10.1042/bj2450933

Published: 01 August 1987

View article titled, Extraction and recovery of inositol phosphates from tissues

Articles

A rapid separation method for inositol phosphates and their isomers

K A Wreggett, R F Irvine

Biochem J (1987) 245 (3): 655–660.

https://doi.org/10.1042/bj2450655

Published: 01 August 1987

View article titled, A rapid separation method for inositol phosphates and their isomers

Articles

Confirmation of the identities of inositol 1,3,4-trisphosphate and inositol 1,3,4,5-tetrakisphosphate by the use of one-dimensional and two-dimensional n.m.r. spectroscopy

J C Lindon, D J Baker, J M Williams, R F Irvine

Biochem J (1987) 244 (3): 591–595.

https://doi.org/10.1042/bj2440591

Published: 15 June 1987

View article titled, Confirmation of the identities of inositol 1,3,4-trisphosphate and inositol 1,3,4,5-tetrakisphosphate by the use of one-dimensional and two-dimensional n.m.r. spectroscopy

Articles

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca 2+

R F Irvine, R M Moor

Biochem J (1986) 240 (3): 917–920.

https://doi.org/10.1042/bj2400917

Published: 15 December 1986

View article titled, Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca 2+

Articles

Specificity of inositol phosphate-stimulated Ca 2+ mobilization from Swiss-mouse 3T3 cells

R F Irvine, A J Letcher, D J Lander, M J Berridge

Biochem J (1986) 240 (1): 301–304.

https://doi.org/10.1042/bj2400301

Published: 15 November 1986

View article titled, Specificity of inositol phosphate-stimulated Ca 2+ mobilization from Swiss-mouse 3T3 cells

Articles

Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

C P Downes, P T Hawkins, R F Irvine

Biochem J (1986) 238 (2): 501–506.

https://doi.org/10.1042/bj2380501

Published: 01 September 1986

View article titled, Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

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