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F. Anthony LAI
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Articles

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

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Sahar I. Da'as, Khalid Fakhro, Angelos Thanassoulas, Navaneethakrishnan Krishnamoorthy, Alaaeldin Saleh, Brian L. Calver, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F. Anthony Lai, Michail Nomikos
Journal: Biochemical Journal
Biochem J (2018) 475 (24): 3933–3948.
https://doi.org/10.1042/BCJ20180685
Published: 14 December 2018
View articletitled, Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction
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Includes: Supplementary data
Articles

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation

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Michail Nomikos, Junaid Kashir, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2017) 474 (21): 3659–3673.
https://doi.org/10.1042/BCJ20160521
Published: 23 October 2017
View articletitled, The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation
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Articles

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ

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Michail Nomikos, Panagiotis Stamatiadis, Jessica R. Sanders, Konrad Beck, Brian L. Calver, Luke Buntwal, Morgan Lofty, Zili Sideratou, Karl Swann, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2017) 474 (6): 1003–1016.
https://doi.org/10.1042/BCJ20161057
Published: 07 March 2017
View articletitled, Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ
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Articles

N-terminus oligomerization is conserved in intracellular calcium release channels

Open Access
Spyros Zissimopoulos, Jason Marsh, Laurence Stannard, Monika Seidel, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2014) 459 (2): 265–273.
https://doi.org/10.1042/BJ20131061
Published: 28 March 2014
View articletitled, N-terminus oligomerization is conserved in intracellular calcium release channels
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Articles

Novel regulation of PLCζ activity via its XY-linker

Open Access
Michail Nomikos, Khalil Elgmati, Maria Theodoridou, Athena Georgilis, J. Raul Gonzalez-Garcia, George Nounesis, Karl Swann, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2011) 438 (3): 427–432.
https://doi.org/10.1042/BJ20110953
Published: 26 August 2011
View articletitled, Novel regulation of PLCζ activity via its XY-linker
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Articles

Divergent effect of mammalian PLCζ in generating Ca 2+ oscillations in somatic cells compared with eggs

Open Access
Sally V. Phillips, Yuansong Yu, Andreas Rossbach, Michail Nomikos, Vyronia Vassilakopoulou, Evangelia Livaniou, Bevan Cumbes, F. Anthony Lai, Christopher H. George, Karl Swann
Journal: Biochemical Journal
Biochem J (2011) 438 (3): 545–553.
https://doi.org/10.1042/BJ20101581
Published: 26 August 2011
View articletitled, Divergent effect of mammalian PLCζ in generating Ca 2+ oscillations in somatic cells compared with eggs
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Includes: Supplementary data
Articles

Male infertility-linked point mutation disrupts the Ca 2+ oscillation-inducing and PIP 2 hydrolysis activity of sperm PLCζ

Open Access
Michail Nomikos, Khalil Elgmati, Maria Theodoridou, Brian L. Calver, Bevan Cumbes, Georg Nounesis, Karl Swann, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2011) 434 (2): 211–217.
https://doi.org/10.1042/BJ20101772
Published: 11 February 2011
View articletitled, Male infertility-linked point mutation disrupts the Ca 2+ oscillation-inducing and PIP 2 hydrolysis activity of sperm PLCζ
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Articles

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

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Spyros Zissimopoulos, N. Lowri Thomas, Wan W. Jamaluddin, F. Anthony Lai
Journal: Biochemical Journal
Biochem J (2009) 419 (2): 273–278.
https://doi.org/10.1042/BJ20082324
Published: 27 March 2009
View articletitled, FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease
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Includes: Supplementary data
Articles

Oligomerization of the cardiac ryanodine receptor C-terminal tail

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Richard STEWART, Spyros ZISSIMOPOULOS, F. Anthony LAI
Journal: Biochemical Journal
Biochem J (2003) 376 (3): 795–799.
https://doi.org/10.1042/bj20030597
Published: 15 December 2003
View articletitled, Oligomerization of the cardiac ryanodine receptor C-terminal tail
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Articles

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

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Christopher H. GEORGE, Rina SORATHIA, Benedicte M.A. BERTRAND, F. Anthony LAI
Journal: Biochemical Journal
Biochem J (2003) 370 (2): 579–589.
https://doi.org/10.1042/bj20021433
Published: 01 March 2003
View articletitled, In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6
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Articles

Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells

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Timothy J. FITZSIMMONS, Ilya GUKOVSKY, James A. McROBERTS, Edward RODRIGUEZ, F. Anthony LAI, Stephen J. PANDOL
Journal: Biochemical Journal
Biochem J (2000) 351 (1): 265–271.
https://doi.org/10.1042/bj3510265
Published: 26 September 2000
View articletitled, Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells
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Articles

The soluble sperm factor that causes Ca2+ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca2+ oscillations after injection into mouse eggs

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John PARRINGTON, Keith T. JONES, F. Anthony LAI, Karl SWANN
Journal: Biochemical Journal
Biochem J (1999) 341 (1): 1–4.
https://doi.org/10.1042/bj3410001
Published: 24 June 1999
View articletitled, The soluble sperm factor that causes Ca2+ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca2+ oscillations after injection into mouse eggs
Open the PDF for The soluble sperm factor that causes Ca2+ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca2+ oscillations after injection into mouse eggs in another window
Articles

Differential expression and regulation of ryanodine receptor and myo -inositol 1,4,5-trisphosphate receptor Ca 2+ release channels in mammalian tissues and cell lines

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John J. MACKRILL, R. A. John CHALLISS, D. A. O'CONNELL, F. Anthony LAI, Stefan R. NAHORSKI
Journal: Biochemical Journal
Biochem J (1997) 327 (1): 251–258.
https://doi.org/10.1042/bj3270251
Published: 01 October 1997
View articletitled, Differential expression and regulation of ryanodine receptor and myo -inositol 1,4,5-trisphosphate receptor Ca 2+ release channels in mammalian tissues and cell lines
Open the PDF for Differential expression and regulation of ryanodine receptor and myo -inositol 1,4,5-trisphosphate receptor Ca 2+ release channels in mammalian tissues and cell lines in another window
Articles

The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis

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Richard E. A. TUNWELL, Colin WICKENDEN, Bénédicte M. A. BERTRAND, Valery I. SHEVCHENKO, Martina B. WALSH, Paul D. ALLEN, F. Anthony LAI
Journal: Biochemical Journal
Biochem J (1996) 318 (2): 477–487.
https://doi.org/10.1042/bj3180477
Published: 01 September 1996
View articletitled, The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis
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Articles

A cytosolic sperm factor triggers calcium oscillations in rat hepatocytes

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Christopher P. BERRIE, K. S. Roy CUTHBERTSON, J. PARRINGTON, F. Anthony LAI, Karl SWANN
Journal: Biochemical Journal
Biochem J (1996) 313 (2): 369–372.
https://doi.org/10.1042/bj3130369
Published: 15 January 1996
View articletitled, A cytosolic sperm factor triggers calcium oscillations in rat hepatocytes
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