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Florian Nachon
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Articles

Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment

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Alexandra D. Kharlamova, Sofya V. Lushchekina, Konstantin A. Petrov, Ekaterina D. Kots, Florian Nachon, Marielle Villard-Wandhammer, Irina V. Zueva, Eric Krejci, Vladimir S. Reznik, Vladimir V. Zobov, Evgeny E. Nikolsky, Patrick Masson
Journal: Biochemical Journal
Biochem J (2016) 473 (9): 1225–1236.
https://doi.org/10.1042/BCJ20160084
Published: 26 April 2016
View articletitled, Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment
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Includes: Supplementary data
Articles

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

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Florian Nachon, Eugénie Carletti, Cyril Ronco, Marie Trovaslet, Yvain Nicolet, Ludovic Jean, Pierre-Yves Renard
Journal: Biochemical Journal
Biochem J (2013) 453 (3): 393–399.
https://doi.org/10.1042/BJ20130013
Published: 12 July 2013
View articletitled, Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
Open the PDF for Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase in another window
Articles

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

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Florian Nachon, Eugenie Carletti, Marielle Wandhammer, Yvain Nicolet, Lawrence M. Schopfer, Patrick Masson, Oksana Lockridge
Journal: Biochemical Journal
Biochem J (2011) 434 (1): 73–82.
https://doi.org/10.1042/BJ20101648
Published: 27 January 2011
View articletitled, X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger
Open the PDF for X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger in another window
Articles

Structure–activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

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Eugénie Carletti, Nadine Aurbek, Emilie Gillon, Mélanie Loiodice, Yvain Nicolet, Juan-Carlos Fontecilla-Camps, Patrick Masson, Horst Thiermann, Florian Nachon, Franz Worek
Journal: Biochemical Journal
Biochem J (2009) 421 (1): 97–106.
https://doi.org/10.1042/BJ20090091
Published: 12 June 2009
View articletitled, Structure–activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun
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