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Interactions of the α 2A -adrenoceptor with multiple G i -family G-proteins: studies with pertussis toxin-resistant G-protein mutants

A. WISE, M.-A. WATSON-KOKEN, S. REES, M. LEE, G. MILLIGAN

Biochem J (1997) 323 (3): 863.

https://doi.org/10.1042/bj3230863v

Published: 01 May 1997

View articletitled, Interactions of the α 2A -adrenoceptor with multiple G i -family G-proteins: studies with pertussis toxin-resistant G-protein mutants

Articles

Chemical inhibition of myristoylation of the G-protein G i1 α by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Evidence that palmitoylation, but not myristoylation, regulates membrane attachment

F GALBIATI, F GUZZI, A I. MAGEE, G MILLIGAN, M PARENTI

Biochem J (1996) 313 (3): 717–720.

https://doi.org/10.1042/bj3130717

Published: 01 February 1996

View articletitled, Chemical inhibition of myristoylation of the G-protein G i1 α by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Evidence that palmitoylation, but not myristoylation, regulates membrane attachment

Articles

The role of palmitoylation of the guanine nucleotide binding protein G 11 α in defining interaction with the plasma membrane

J F McCallum, A Wise, M A Grassie, A I Magee, F Guzzi, M Parenti, G Milligan

Biochem J (1995) 310 (3): 1021–1027.

https://doi.org/10.1042/bj3101021

Published: 15 September 1995

View articletitled, The role of palmitoylation of the guanine nucleotide binding protein G 11 α in defining interaction with the plasma membrane

Articles

Comparison of the signalling properties of the long and short isoforms of the rat thyrotropin-releasing-hormone receptor following expression in rat 1 fibroblasts

T W Lee, L A Anderson, K A Eidne, G Milligan

Biochem J (1995) 310 (1): 291–298.

https://doi.org/10.1042/bj3100291

Published: 15 August 1995

View articletitled, Comparison of the signalling properties of the long and short isoforms of the rat thyrotropin-releasing-hormone receptor following expression in rat 1 fibroblasts

Articles

Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and β 2-adrenoceptor-expressing NG108-15 cells

G D Kim, I C Carr, G Milligan

Biochem J (1995) 308 (1): 275–281.

https://doi.org/10.1042/bj3080275

Published: 15 May 1995

View articletitled, Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and β 2-adrenoceptor-expressing NG108-15 cells

Articles

Analysis of the relative interactions between the α 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G o 1 α and G i 2 α following co-expression of these polypeptides in rat 1 fibroblasts

M A Grassie, G Milligan

Biochem J (1995) 306 (2): 525–530.

https://doi.org/10.1042/bj3060525

Published: 01 March 1995

View articletitled, Analysis of the relative interactions between the α 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G o 1 α and G i 2 α following co-expression of these polypeptides in rat 1 fibroblasts

Articles

Immunoprecipitation of opioid receptor-G o -protein complexes using specific GTP-binding-protein antisera

Z Georgoussi, G Milligan, C Zioudrou

Biochem J (1995) 306 (1): 71–75.

https://doi.org/10.1042/bj3060071

Published: 15 February 1995

View articletitled, Immunoprecipitation of opioid receptor-G o -protein complexes using specific GTP-binding-protein antisera

Articles

The turkey erythrocyte β -adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein α subunits

S R James, C Vaziri, T R Walker, G Milligan, C P Downes

Biochem J (1994) 304 (2): 359–364.

https://doi.org/10.1042/bj3040359

Published: 01 December 1994

View articletitled, The turkey erythrocyte β -adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein α subunits

Articles

N-terminal fatty acylation of the α-subunit of the G-protein G i 1: only the myristoylated protein is a substrate for palmitoylation

F Galbiati, F Guzzi, A I Magee, G Milligan, M Parenti

Biochem J (1994) 303 (3): 697–700.

https://doi.org/10.1042/bj3030697

Published: 01 November 1994

View articletitled, N-terminal fatty acylation of the α-subunit of the G-protein G i 1: only the myristoylated protein is a substrate for palmitoylation

Articles

Regulation of basal adenylate cyclase activity in neuroblastoma × glioma hybrid, NG108-15, cells transfected to express the human β 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade

E J Adie, G Milligan

Biochem J (1994) 303 (3): 803–808.

https://doi.org/10.1042/bj3030803

Published: 01 November 1994

View articletitled, Regulation of basal adenylate cyclase activity in neuroblastoma × glioma hybrid, NG108-15, cells transfected to express the human β 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade

Articles

β 3-adrenoceptor agonist-induced down-regulation of G s α and functional desensitization in a Chinese hamster ovary cell line expressing a β 3-adrenoceptor refractory to down-regulation

J Chambers, J Park, D Cronk, C Chapman, F R Kennedy, S Wilson, G Milligan

Biochem J (1994) 303 (3): 973–978.

https://doi.org/10.1042/bj3030973

Published: 01 November 1994

View articletitled, β 3-adrenoceptor agonist-induced down-regulation of G s α and functional desensitization in a Chinese hamster ovary cell line expressing a β 3-adrenoceptor refractory to down-regulation

Articles

The palmitoylation status of the G-protein G o 1 α regulates its activity of interaction with the plasma membrane

M A Grassie, J F McCallum, F Guzzi, A I Magee, G Milligan, M Parenti

Biochem J (1994) 302 (3): 913–920.

https://doi.org/10.1042/bj3020913

Published: 15 September 1994

View articletitled, The palmitoylation status of the G-protein G o 1 α regulates its activity of interaction with the plasma membrane

Articles

Agonist regulation of cellular G s α-subunit levels in neuroblastoma × glioma hybrid NG108-15 cells transfected to express different levels of the human β 2 adrenoceptor

E J Adie, G Milligan

Biochem J (1994) 300 (3): 709–715.

https://doi.org/10.1042/bj3000709

Published: 15 June 1994

View articletitled, Agonist regulation of cellular G s α-subunit levels in neuroblastoma × glioma hybrid NG108-15 cells transfected to express different levels of the human β 2 adrenoceptor

Articles

Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [ 32 P]ADP-ribosylation of G i by lysophosphatidic acid (LPA) in wild-type and α2C10 adrenoceptor-transfected Rat 1 fibroblasts

C Carr, M Grassie, G Milligan

Biochem J (1994) 298 (2): 493–497.

https://doi.org/10.1042/bj2980493

Published: 01 March 1994

View articletitled, Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [ 32 P]ADP-ribosylation of G i by lysophosphatidic acid (LPA) in wild-type and α2C10 adrenoceptor-transfected Rat 1 fibroblasts

Articles

Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein G q α/G 11 α following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

F M Mitchell, N J Buckley, G Milligan

Biochem J (1993) 293 (2): 495–499.

https://doi.org/10.1042/bj2930495

Published: 15 July 1993

View articletitled, Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein G q α/G 11 α following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

Articles

A novel N-terminal motif for palmitoylation of G-protein α subunits

M Parenti, M A Viganó, C M H Newman, G Milligan, A I Magee

Biochem J (1993) 291 (2): 349–353.

https://doi.org/10.1042/bj2910349

Published: 15 April 1993

View articletitled, A novel N-terminal motif for palmitoylation of G-protein α subunits

Articles

Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the α subunit of the G-protein G q

I Mullaney, M W Dodd, N Buckley, G Milligan

Biochem J (1993) 289 (1): 125–131.

https://doi.org/10.1042/bj2890125

Published: 01 January 1993

View articletitled, Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the α subunit of the G-protein G q

Articles

Concurrent down-regulation of IP prostanoid receptors and the α -subunit of the stimulatory guanine-nucleotide-binding protein (G s ) during prolonged exposure of neuroblastoma × glioma cells to prostanoid agonists. Quantification and functional implications

E J Adie, I Mullaney, F R McKenzie, G Milligan

Biochem J (1992) 285 (2): 529–536.

https://doi.org/10.1042/bj2850529

Published: 15 July 1992

View articletitled, Concurrent down-regulation of IP prostanoid receptors and the α -subunit of the stimulatory guanine-nucleotide-binding protein (G s ) during prolonged exposure of neuroblastoma × glioma cells to prostanoid agonists. Quantification and functional implications

Articles

G i 3 does not contribute to the inhibition of adenylate cyclase when stimulation of an α 2 -adrenergic receptor causes activation of both G i 2 and G i 3

S J McClue, E Selzer, M Freissmuth, G Milligan

Biochem J (1992) 284 (2): 565–568.

https://doi.org/10.1042/bj2840565

Published: 01 June 1992

View articletitled, G i 3 does not contribute to the inhibition of adenylate cyclase when stimulation of an α 2 -adrenergic receptor causes activation of both G i 2 and G i 3

Articles

Regulation of cardiac adenylate cyclase activity in rodent models of obesity

D Strassheim, M D Houslay, G Milligan

Biochem J (1992) 283 (1): 203–208.

https://doi.org/10.1042/bj2830203

Published: 01 April 1992

View articletitled, Regulation of cardiac adenylate cyclase activity in rodent models of obesity

Articles

Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese ( fa / fa ) Zucker rats

D Strassheim, T Palmer, G Milligan, M D Houslay

Biochem J (1991) 276 (1): 197–202.

https://doi.org/10.1042/bj2760197

Published: 15 May 1991

View articletitled, Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese ( fa / fa ) Zucker rats

Articles

Abundance of the α-subunits of G i 1, G i 2 and G o in synaptosomal membranes from several regions of the rat brain is increased in hypothyroidism

M Orford, D Mazurkiewicz, G Milligan, D Saggerson

Biochem J (1991) 275 (1): 183–186.

https://doi.org/10.1042/bj2750183

Published: 01 April 1991

View articletitled, Abundance of the α-subunits of G i 1, G i 2 and G o in synaptosomal membranes from several regions of the rat brain is increased in hypothyroidism

Articles

Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma × glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels

F R McKenzie, G Milligan

Biochem J (1991) 275 (1): 175–181.

https://doi.org/10.1042/bj2750175

Published: 01 April 1991

View articletitled, Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma × glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels

Articles

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein G i -2 in hepatocytes

M Bushfield, S L Griffiths, G J Murphy, N J Pyne, J T Knowler, G Milligan, P J Parker, S Mollner, M D Houslay

Biochem J (1990) 271 (2): 365–372.

https://doi.org/10.1042/bj2710365

Published: 15 October 1990

View articletitled, Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein G i -2 in hepatocytes

Articles

Concurrent up-regulation of guanine-nucleotide-binding proteins G i 1 α , G i 2 α and G i 3 α in adipocytes of hypothyroid rats

G Milligan, E D Saggerson

Biochem J (1990) 270 (3): 765–769.

https://doi.org/10.1042/bj2700765

Published: 15 September 1990

View articletitled, Concurrent up-regulation of guanine-nucleotide-binding proteins G i 1 α , G i 2 α and G i 3 α in adipocytes of hypothyroid rats

Articles

Hormonal regulation of G i 2 α -subunit phosphorylation in intact hepatocytes

M Bushfield, G J Murphy, B E Lavan, P J Parker, V J Hruby, G Milligan, M D Houslay

Biochem J (1990) 268 (2): 449–457.

https://doi.org/10.1042/bj2680449

Published: 01 June 1990

View articletitled, Hormonal regulation of G i 2 α -subunit phosphorylation in intact hepatocytes

Articles

δ -opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein G i 2

F R McKenzie, G Milligan

Biochem J (1990) 267 (2): 391–398.

https://doi.org/10.1042/bj2670391

Published: 15 April 1990

View articletitled, δ -opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein G i 2

Articles

Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (G i ) on adipocyte adenylate cyclase activity

D Strassheim, G Milligan, M D Houslay

Biochem J (1990) 266 (2): 521–526.

https://doi.org/10.1042/bj2660521

Published: 01 March 1990

View articletitled, Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (G i ) on adipocyte adenylate cyclase activity

Articles

Adipocyte plasma-membrane G i and G s in insulinopenic diabetic patients

J J Ohisalo, H L Vikman, S Ranta, M D Houslay, G Milligan

Biochem J (1989) 264 (1): 289–292.

https://doi.org/10.1042/bj2640289

Published: 15 November 1989

View articletitled, Adipocyte plasma-membrane G i and G s in insulinopenic diabetic patients

Articles

Cholera toxin treatment produces down-regulation of the α -subunit of the stimulatory guanine-nucleotide-binding protein (G s )

G Milligan, C G Unson, M J Wakelam

Biochem J (1989) 262 (2): 643–649.

https://doi.org/10.1042/bj2620643

Published: 01 September 1989

View articletitled, Cholera toxin treatment produces down-regulation of the α -subunit of the stimulatory guanine-nucleotide-binding protein (G s )

Articles

Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to G i 1, G i 2 and G i 3

F M Mitchell, S L Griffiths, E D Saggerson, M D Houslay, J T Knowler, G Milligan

Biochem J (1989) 262 (2): 403–408.

https://doi.org/10.1042/bj2620403

Published: 01 September 1989

View articletitled, Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to G i 1, G i 2 and G i 3

Articles

Distribution of G-proteins in rat liver plasma-membrane domains and endocytic pathways

N Ali, G Milligan, W H Evans

Biochem J (1989) 261 (3): 905–912.

https://doi.org/10.1042/bj2610905

Published: 01 August 1989

View articletitled, Distribution of G-proteins in rat liver plasma-membrane domains and endocytic pathways

Articles

Persistent activation of the α subunit of G s promotes its removal from the plasma membrane

G Milligan, C G Unson

Biochem J (1989) 260 (3): 837–841.

https://doi.org/10.1042/bj2600837

Published: 15 June 1989

View articletitled, Persistent activation of the α subunit of G s promotes its removal from the plasma membrane

Articles

Guanine-nucleotide-binding proteins G i and G s in fat-cells from normal, hypothyroid and obese human subjects

J J Ohisalo, G Milligan

Biochem J (1989) 260 (3): 843–847.

https://doi.org/10.1042/bj2600843

Published: 15 June 1989

View articletitled, Guanine-nucleotide-binding proteins G i and G s in fat-cells from normal, hypothyroid and obese human subjects

Articles

The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding

S D Gardner, G Milligan, J E Rice, M J Wakelam

Biochem J (1989) 259 (3): 679–684.

https://doi.org/10.1042/bj2590679

Published: 01 May 1989

View articletitled, The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding

Articles

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein G i , which is inactivated upon challenge of hepatocytes with glucagon

G J Murphy, D J Gawler, G Milligan, M J O Wakelam, N J Pyne, M D Houslay

Biochem J (1989) 259 (1): 191–197.

https://doi.org/10.1042/bj2590191

Published: 01 April 1989

View articletitled, Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein G i , which is inactivated upon challenge of hepatocytes with glucagon

Articles

Differential regulation of amounts of the guanine-nucleotide-binding proteins G i and G o in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.

I Mullaney, A I Magee, C G Unson, G Milligan

Biochem J (1988) 256 (2): 649–656.

https://doi.org/10.1042/bj2560649

Published: 01 December 1988

View articletitled, Differential regulation of amounts of the guanine-nucleotide-binding proteins G i and G o in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.

Articles

Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins

G Milligan

Biochem J (1988) 255 (1): 1–13.

https://doi.org/10.1042/bj2550001

Published: 01 October 1988

View articletitled, Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins

Articles

GTP analogues promote release of the α subunit of the guanine nucleotide binding protein, G i 2, from membranes of rat glioma C6 BU1 cells

G Milligan, I Mullaney, C G Unson, L Marshall, A M Spiegel, H McArdle

Biochem J (1988) 254 (2): 391–396.

https://doi.org/10.1042/bj2540391

Published: 01 September 1988

View articletitled, GTP analogues promote release of the α subunit of the guanine nucleotide binding protein, G i 2, from membranes of rat glioma C6 BU1 cells

Articles

Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (G i ) in membranes of neuroblastoma x glioma hybrid cells

G Milligan, F R McKenzie

Biochem J (1988) 252 (2): 369–373.

https://doi.org/10.1042/bj2520369

Published: 01 June 1988

View articletitled, Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (G i ) in membranes of neuroblastoma x glioma hybrid cells

Articles

Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins

S J Butler, E C H Kelly, F R McKenzie, S B Guild, M J O Wakelam, G Milligan

Biochem J (1988) 251 (1): 201–205.

https://doi.org/10.1042/bj2510201

Published: 01 April 1988

View articletitled, Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins

Articles

Antibodies which recognize the C -terminus of the inhibitory guanine-nucleotide-binding protein (G i ) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates

F R McKenzie, E C H Kelly, C G Unson, A M Spiegel, G Milligan

Biochem J (1988) 249 (3): 653–659.

https://doi.org/10.1042/bj2490653

Published: 01 February 1988

View articletitled, Antibodies which recognize the C -terminus of the inhibitory guanine-nucleotide-binding protein (G i ) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates

Articles

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein G i

D Gawler, G Milligan, M D Houslay

Biochem J (1988) 249 (2): 537–542.

https://doi.org/10.1042/bj2490537

Published: 15 January 1988

View articletitled, Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein G i

Articles

Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated ‘dense-vesicle’ and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat

N J Pyne, N Anderson, B E Lavan, G Milligan, H G Nimmo, M D Houslay

Biochem J (1987) 248 (3): 897–901.

https://doi.org/10.1042/bj2480897

Published: 15 December 1987

View articletitled, Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated ‘dense-vesicle’ and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat

Articles

Chemically induced hypothyroidism produces elevated amounts of the α subunit of the inhibitory guanine nucleotide binding protein (G i ) and the β subunit common to all G-proteins

G Milligan, A M Spiegel, C G Unson, E D Saggerson

Biochem J (1987) 247 (1): 223–227.

https://doi.org/10.1042/bj2470223

Published: 01 October 1987

View articletitled, Chemically induced hypothyroidism produces elevated amounts of the α subunit of the inhibitory guanine nucleotide binding protein (G i ) and the β subunit common to all G-proteins

Articles

Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells

G Milligan

Biochem J (1987) 245 (2): 501–505.

https://doi.org/10.1042/bj2450501

Published: 15 July 1987

View articletitled, Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells

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