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George S. Baillie
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Articles

Charting the importance of filamin A posttranslational modifications

Open Access
Kyle D. Shead, Veneta Salyahetdinova, George S. Baillie
Journal: Biochemical Journal
Biochem J (2024) 481 (13): 865–881.
https://doi.org/10.1042/BCJ20240121
Published: 03 July 2024
View articletitled, Charting the importance of filamin A posttranslational modifications
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Articles

Revisiting the roles of cAMP signalling in the progression of prostate cancer

Open Access
Emma C. Parsons, Ralf Hoffmann, George S. Baillie
Journal: Biochemical Journal
Biochem J (2023) 480 (20): 1599–1614.
https://doi.org/10.1042/BCJ20230297
Published: 13 October 2023
View articletitled, Revisiting the roles of cAMP signalling in the progression of prostate cancer
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Articles

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

Open Access
Kirsty F. Houslay, Frank Christian, Ruth MacLeod, David R. Adams, Miles D. Houslay, George S. Baillie
Journal: Biochemical Journal
Biochem J (2017) 474 (4): 597–609.
https://doi.org/10.1042/BCJ20160849
Published: 03 February 2017
View articletitled, Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners
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Articles

The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser 16

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Helen V. Edwards, John D. Scott, George S. Baillie
Journal: Biochemical Journal
Biochem J (2012) 446 (3): 437–443.
https://doi.org/10.1042/BJ20120570
Published: 28 August 2012
View articletitled, The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser 16
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Articles

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

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Kirsty F. MacKenzie, Derek A. Wallace, Elaine V. Hill, Diana F. Anthony, David J. P. Henderson, Daniel M. Houslay, J. Simon C. Arthur, George S. Baillie, Miles D. Houslay
Journal: Biochemical Journal
Biochem J (2011) 435 (3): 755–769.
https://doi.org/10.1042/BJ20101184
Published: 13 April 2011
View articletitled, Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation
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Articles

Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

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Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexandra Kaupisch, Nicole M. Kane, George S. Baillie, Andrew H. Baker, Graeme Milligan, Miles D. Houslay, Joanne C. Mountford
Journal: Biochemical Journal
Biochem J (2010) 432 (3): 575–599.
https://doi.org/10.1042/BJ20100726
Published: 25 November 2010
View articletitled, Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells
Open the PDF for Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells in another window
Includes: Supplementary data
Articles

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Open Access
Rebecca J. Bird, George S. Baillie, Stephen J. Yarwood
Journal: Biochemical Journal
Biochem J (2010) 432 (1): 207–219.
https://doi.org/10.1042/BJ20101010
Published: 25 October 2010
View articletitled, Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C
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Includes: Supplementary data
Articles

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

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Xiang Li, Suryakiran Vadrevu, Allan Dunlop, Jon Day, Noopur Advant, Jessica Troeger, Enno Klussmann, Ellis Jaffrey, Ron T. Hay, David R. Adams, Miles D. Houslay, George S. Baillie
Journal: Biochemical Journal
Biochem J (2010) 428 (1): 55–65.
https://doi.org/10.1042/BJ20091672
Published: 28 April 2010
View articletitled, Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK
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Articles

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs

Available to Purchase
Tian-Rui Xu, George S. Baillie, Narinder Bhari, Thomas M. Houslay, Andrew M. Pitt, David R. Adams, Walter Kolch, Miles D. Houslay, Graeme Milligan
Journal: Biochemical Journal
Biochem J (2008) 413 (1): 51–60.
https://doi.org/10.1042/BJ20080685
Published: 12 June 2008
View articletitled, Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs
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Articles

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

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Kirsty F. Mackenzie, Emma C. Topping, Bozena Bugaj-Gaweda, Chengjun Deng, York-Fong Cheung, Aileen E. Olsen, Cecil R. Stockard, Lisa High Mitchell, George S. Baillie, William E. Grizzle, Michael De Vivo, Miles D. Houslay, Daguang Wang, Graeme B. Bolger
Journal: Biochemical Journal
Biochem J (2008) 411 (2): 361–369.
https://doi.org/10.1042/BJ20071251
Published: 27 March 2008
View articletitled, Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change
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Articles

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

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George S. Baillie, David R. Adams, Narinder Bhari, Thomas M. Houslay, Suryakiran Vadrevu, Dong Meng, Xiang Li, Allan Dunlop, Graeme Milligan, Graeme B. Bolger, Enno Klussmann, Miles D. Houslay
Journal: Biochemical Journal
Biochem J (2007) 404 (1): 71–80.
https://doi.org/10.1042/BJ20070005
Published: 26 April 2007
View articletitled, Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays
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Articles

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

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Graeme B. Bolger, George S. Baillie, Xiang Li, Martin J. Lynch, Pawel Herzyk, Ahmed Mohamed, Lisa High Mitchell, Angela McCahill, Christian Hundsrucker, Enno Klussmann, David R. Adams, Miles D. Houslay
Journal: Biochemical Journal
Biochem J (2006) 398 (1): 23–36.
https://doi.org/10.1042/BJ20060423
Published: 27 July 2006
View articletitled, Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
Open the PDF for Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5 in another window
Articles

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes

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Xiang Li, Elaine Huston, Martin J. Lynch, Miles D. Houslay, George S. Baillie
Journal: Biochemical Journal
Biochem J (2006) 394 (2): 427–435.
https://doi.org/10.1042/BJ20051560
Published: 10 February 2006
View articletitled, Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes
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Articles

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

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Lee Ann JOHNSTON, Suat ERDOGAN, York Fong CHEUNG, Michael SULLIVAN, Rachael BARBER, Martin J. LYNCH, George S. BAILLIE, Gino VAN HEEKE, David R. ADAMS, Elaine HUSTON, Miles D. HOUSLAY
Journal: Biochemical Journal
Biochem J (2004) 380 (2): 371–384.
https://doi.org/10.1042/bj20031662
Published: 01 June 2004
View articletitled, Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene
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Articles

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

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Malcolm SHEPHERD, Theresa McSORLEY, Aileen E. OLSEN, Lee Ann JOHNSTON, Neil C. THOMSON, George S. BAILLIE, Miles D. HOUSLAY, Graeme B. BOLGER
Journal: Biochemical Journal
Biochem J (2003) 370 (2): 429–438.
https://doi.org/10.1042/bj20021082
Published: 01 March 2003
View articletitled, Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform
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