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Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Richard J. Ward, John D. Pediani, Kaleeckal G. Harikumar, Laurence J. Miller, Graeme Milligan

Biochem J (2017) 474 (11): 1879–1895.

https://doi.org/10.1042/BCJ20170184

Published: 24 May 2017

View articletitled, Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Articles

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

Linas Zakrys, Richard J. Ward, John D. Pediani, Antoine G. Godin, Gerard J. Graham, Graeme Milligan

Biochem J (2014) 461 (1): 61–73.

https://doi.org/10.1042/BJ20140190

Published: 13 June 2014

View articletitled, Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

Articles

The muscarinic M 3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane

Suparna Patowary, Elisa Alvarez-Curto, Tian-Rui Xu, Jessica D. Holz, Julie A. Oliver, Graeme Milligan, Valerică Raicu

Biochem J (2013) 452 (2): 303–312.

https://doi.org/10.1042/BJ20121902

Published: 10 May 2013

View articletitled, The muscarinic M 3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane

Includes: Supplementary data

Articles

The orexin OX 1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

Tian-Rui Xu, Richard J. Ward, John D. Pediani, Graeme Milligan

Biochem J (2011) 439 (1): 171–183.

https://doi.org/10.1042/BJ20110230

Published: 14 September 2011

View articletitled, The orexin OX 1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

Includes: Supplementary data

Articles

Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexandra Kaupisch, Nicole M. Kane, George S. Baillie, Andrew H. Baker, Graeme Milligan, Miles D. Houslay, Joanne C. Mountford

Biochem J (2010) 432 (3): 575–599.

https://doi.org/10.1042/BJ20100726

Published: 25 November 2010

View articletitled, Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Includes: Supplementary data

Articles

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate G α13

Laura Jenkins, Jose Brea, Nicola J. Smith, Brian D. Hudson, Graeme Reilly, Nia J. Bryant, Marian Castro, María-Isabel Loza, Graeme Milligan

Biochem J (2010) 432 (3): 451–459.

https://doi.org/10.1042/BJ20101287

Published: 25 November 2010

View articletitled, Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate G α13

Articles

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Paul D. Andrews, Melissa Becroft, Anders Aspegren, Jane Gilmour, Martyn J. James, Scott McRae, Robert Kime, Robert W. Allcock, Achamma Abraham, Zhong Jiang, Raimund Strehl, Joanne C. Mountford, Graeme Milligan, Miles D. Houslay, David R. Adams, Julie A. Frearson

Biochem J (2010) 432 (1): 21–35.

https://doi.org/10.1042/BJ20101022

Published: 25 October 2010

View articletitled, High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Includes: Supplementary data

Articles

Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α 1b -adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

Meritxell Canals, Juan F. Lopez-Gimenez, Graeme Milligan

Biochem J (2009) 417 (1): 161–172.

https://doi.org/10.1042/BJ20081227

Published: 12 December 2008

View articletitled, Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α 1b -adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

Articles

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs

Tian-Rui Xu, George S. Baillie, Narinder Bhari, Thomas M. Houslay, Andrew M. Pitt, David R. Adams, Walter Kolch, Miles D. Houslay, Graeme Milligan

Biochem J (2008) 413 (1): 51–60.

https://doi.org/10.1042/BJ20080685

Published: 12 June 2008

View articletitled, Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs

Articles

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Geraldine Parenty, Shirley Appelbe, Graeme Milligan

Biochem J (2008) 412 (2): 245–256.

https://doi.org/10.1042/BJ20071689

Published: 14 May 2008

View articletitled, CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Articles

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

George S. Baillie, David R. Adams, Narinder Bhari, Thomas M. Houslay, Suryakiran Vadrevu, Dong Meng, Xiang Li, Allan Dunlop, Graeme Milligan, Graeme B. Bolger, Enno Klussmann, Miles D. Houslay

Biochem J (2007) 404 (1): 71–80.

https://doi.org/10.1042/BJ20070005

Published: 26 April 2007

View articletitled, Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

Articles

The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation

Sandra MILASTA, Nicholas A. EVANS, Laura ORMISTON, Shelagh WILSON, Robert J. LEFKOWITZ, Graeme MILLIGAN

Biochem J (2005) 387 (3): 573–584.

https://doi.org/10.1042/BJ20041745

Published: 26 April 2005

View articletitled, The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation

Articles

Activation of an α 2A -adrenoceptor–Gα o1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor

Elaine BARCLAY, Mark O'REILLY, Graeme MILLIGAN

Biochem J (2005) 385 (1): 197–206.

https://doi.org/10.1042/BJ20041432

Published: 14 December 2004

View articletitled, Activation of an α 2A -adrenoceptor–Gα o1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor

Articles

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

Douglas RAMSAY, Elaine KELLETT, Mary McVEY, Stephen REES, Graeme MILLIGAN

Biochem J (2002) 365 (2): 429–440.

https://doi.org/10.1042/bj20020251

Published: 15 July 2002

View articletitled, Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

Articles

Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations of the long isoform of the rat thyrotropin-releasing hormone receptor-1

Tomas DRMOTA, Graeme MILLIGAN

Biochem J (2000) 346 (3): 711–718.

https://doi.org/10.1042/bj3460711

Published: 07 March 2000

View articletitled, Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations of the long isoform of the rat thyrotropin-releasing hormone receptor-1

Articles

Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins

Chee Wai FONG, Graeme MILLIGAN

Biochem J (1999) 342 (2): 457–463.

https://doi.org/10.1042/bj3420457

Published: 24 August 1999

View articletitled, Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins

Articles

Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and Gqα /G11α induced by agonist stimulation

Tomas DRMOTA, Jiri NOVOTNY, Gwyn W. GOULD, Petr SVOBODA, Graeme MILLIGAN

Biochem J (1999) 340 (2): 529–538.

https://doi.org/10.1042/bj3400529

Published: 25 May 1999

View articletitled, Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and Gqα /G11α induced by agonist stimulation

Includes: Supplementary data

Articles

Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster α1B-adrenoceptor by ligands that act as inverse agonists

Tae Weon LEE, Susanna COTECCHIA, Graeme MILLIGAN

Biochem J (1997) 325 (3): 733–739.

https://doi.org/10.1042/bj3250733

Published: 01 August 1997

View articletitled, Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster α1B-adrenoceptor by ligands that act as inverse agonists

Articles

Mitogenic signalling by δ opioid receptors expressed in Rat-1 fibroblasts involves activation of the p70 s6k /p85 s6k S6 kinase

Moira A. WILSON, Andrew R. BURT, Graeme MILLIGAN, Neil G. ANDERSON

Biochem J (1997) 325 (1): 217–222.

https://doi.org/10.1042/bj3250217

Published: 01 July 1997

View articletitled, Mitogenic signalling by δ opioid receptors expressed in Rat-1 fibroblasts involves activation of the p70 s6k /p85 s6k S6 kinase

Articles

Measurement of agonist-induced guanine nucleotide turnover by the G-protein G i1 α when constrained within an α 2A -adrenoceptor-G i1 α fusion protein

Alan WISE, I. Craig CARR, Graeme MILLIGAN

Biochem J (1997) 325 (1): 17–21.

https://doi.org/10.1042/bj3250017

Published: 01 July 1997

View articletitled, Measurement of agonist-induced guanine nucleotide turnover by the G-protein G i1 α when constrained within an α 2A -adrenoceptor-G i1 α fusion protein

Articles

Interactions of the α2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants

Alan WISE, Marie-Ange WATSON-KOKEN, Stephen REES, Melanie LEE, Graeme MILLIGAN

Biochem J (1997) 321 (3): 721–728.

https://doi.org/10.1042/bj3210721

Published: 01 February 1997

View articletitled, Interactions of the α2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants

Articles

Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae

GRANT Karen R., Margaret M. HARNETT, Graeme MILLIGAN, William HARNETT

Biochem J (1996) 320 (2): 459–466.

https://doi.org/10.1042/bj3200459

Published: 01 December 1996

View articletitled, Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae

Articles

A constitutively active mutant of the α 1B -adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G q α and G 11 α than the wild-type receptor

Tae Weon LEE, Alan WISE, Susanna COTECCHIA, Graeme MILLIGAN

Biochem J (1996) 320 (1): 79–86.

https://doi.org/10.1042/bj3200079

Published: 15 November 1996

View articletitled, A constitutively active mutant of the α 1B -adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G q α and G 11 α than the wild-type receptor

Articles

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

Andrew R BURT, I. Craig CARR, Ian MULLANEY, Neil G. ANDERSON, Graeme MILLIGAN

Biochem J (1996) 320 (1): 227–235.

https://doi.org/10.1042/bj3200227

Published: 15 November 1996

View articletitled, Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

Articles

Agonist regulation of adenylate cyclase activity in neuroblastoma × glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the β 2 -adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity

David J. MACEWAN, Gun-Do KIM, Graeme MILLIGAN

Biochem J (1996) 318 (3): 1033–1039.

https://doi.org/10.1042/bj3181033

Published: 15 September 1996

View articletitled, Agonist regulation of adenylate cyclase activity in neuroblastoma × glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the β 2 -adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity

Articles

Analysis of inverse agonism at the δ opioid receptor after expression in Rat 1 fibroblasts

Ian MULLANEY, I. Craig CARR, Graeme MILLIGAN

Biochem J (1996) 315 (1): 227–234.

https://doi.org/10.1042/bj3150227

Published: 01 April 1996

View articletitled, Analysis of inverse agonism at the δ opioid receptor after expression in Rat 1 fibroblasts

Articles

Cold-induced reduction in G i α proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment

Petr SVOBODA, Lena UNELIUS, Andrea DICKER, Barbara CANNON, Graeme MILLIGAN, Jan NEDERGAARD

Biochem J (1996) 314 (3): 761–768.

https://doi.org/10.1042/bj3140761

Published: 15 March 1996

View articletitled, Cold-induced reduction in G i α proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment

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Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

The muscarinic M 3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane

The orexin OX 1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate G α13

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α 1b -adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β 2 -adrenoceptor and the ERK1/2 MAPKs: implications for β 2 -adrenoceptor signalling via the ERK1/2 MAPKs

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation

Activation of an α 2A -adrenoceptor–Gα o1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations of the long isoform of the rat thyrotropin-releasing hormone receptor-1

Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins

Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and Gqα /G11α induced by agonist stimulation

Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster α1B-adrenoceptor by ligands that act as inverse agonists

Mitogenic signalling by δ opioid receptors expressed in Rat-1 fibroblasts involves activation of the p70 s6k /p85 s6k S6 kinase

Measurement of agonist-induced guanine nucleotide turnover by the G-protein G i1 α when constrained within an α 2A -adrenoceptor-G i1 α fusion protein

Interactions of the α2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants

Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae

A constitutively active mutant of the α 1B -adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G q α and G 11 α than the wild-type receptor

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

Agonist regulation of adenylate cyclase activity in neuroblastoma × glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the β 2 -adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity

Analysis of inverse agonism at the δ opioid receptor after expression in Rat 1 fibroblasts

Cold-induced reduction in G i α proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment

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