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Guy S. Salvesen
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Articles

Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome

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Scott J. Snipas, Roberto Jappelli, Ali Torkamani, Giovanni Paternostro, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2022) 479 (14): 1533–1542.
https://doi.org/10.1042/BCJ20220166
Published: 21 July 2022
View articletitled, Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome
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Includes: Supplementary data
Articles

Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7

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Izabela Maluch, Justyna Grzymska, Scott J. Snipas, Guy S. Salvesen, Marcin Drag
Journal: Biochemical Journal
Biochem J (2021) 478 (12): 2233–2245.
https://doi.org/10.1042/BCJ20210255
Published: 18 June 2021
View articletitled, Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7
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Includes: Supplementary data
Articles

Mousing around with caspases and IAPs

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Robert C. Rickert, Guy S. Salvesen, Carl F. Ware
Journal: Biochemical Journal
Biochem J (2012) 443 (2): e1–e2.
https://doi.org/10.1042/BJ20120402
Published: 27 March 2012
View articletitled, Mousing around with caspases and IAPs
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Articles

Mechanism and specificity of the human paracaspase MALT1

Open Access
Janna Hachmann, Scott J. Snipas, Bram J. van Raam, Erik M. Cancino, Emily J. Houlihan, Marcin Poreba, Paulina Kasperkiewicz, Marcin Drag, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2012) 443 (1): 287–295.
https://doi.org/10.1042/BJ20120035
Published: 14 March 2012
View articletitled, Mechanism and specificity of the human paracaspase MALT1
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Articles

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

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Efthalia Zervoudi, Athanasios Papakyriakou, Dimitra Georgiadou, Irini Evnouchidou, Anna Gajda, Marcin Poreba, Guy S. Salvesen, Marcin Drag, Akira Hattori, Luc Swevers, Dionisios Vourloumis, Efstratios Stratikos
Journal: Biochemical Journal
Biochem J (2011) 435 (2): 411–420.
https://doi.org/10.1042/BJ20102049
Published: 29 March 2011
View articletitled, Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
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Includes: Supplementary data
Articles

FLIP L induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

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Cristina Pop, Andrew Oberst, Marcin Drag, Bram J. Van Raam, Stefan J. Riedl, Douglas R. Green, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2011) 433 (3): 447–457.
https://doi.org/10.1042/BJ20101738
Published: 14 January 2011
View articletitled, FLIP L induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
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Includes: Supplementary data
Articles

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

Open Access
Jad Walters, Cristina Pop, Fiona L. Scott, Marcin Drag, Paul Swartz, Carla Mattos, Guy S. Salvesen, A. Clay Clark
Journal: Biochemical Journal
Biochem J (2009) 424 (3): 335–345.
https://doi.org/10.1042/BJ20090825
Published: 10 December 2009
View articletitled, A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
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Includes: Multimedia, Supplementary data
Articles

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)

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Marcin Drag, Jowita Mikolajczyk, Miklos Bekes, Francisca E. Reyes-Turcu, Jonathan A. Ellman, Keith D. Wilkinson, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2008) 415 (3): 367–375.
https://doi.org/10.1042/BJ20080779
Published: 15 October 2008
View articletitled, Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
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Articles

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

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Marcin Drag, Jowita Mikolajczyk, I. M. Krishnakumar, Ziwei Huang, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 461–469.
https://doi.org/10.1042/BJ20070940
Published: 21 December 2007
View articletitled, Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
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Includes: Supplementary data
Articles

Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking

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Yi I. Wu, Hidayatullah G. Munshi, Scott J. Snipas, Guy S. Salvesen, Rafael Fridman, M. Sharon Stack
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 171–177.
https://doi.org/10.1042/BJ20070552
Published: 25 September 2007
View articletitled, Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking
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Articles

Profiling constitutive proteolytic events in vivo

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John C. Timmer, Mari Enoksson, Eric Wildfang, Wenhong Zhu, Yoshinobu Igarashi, Jean-Benard Denault, Yuliang Ma, Benjamin Dummitt, Yie-Hwa Chang, Alan E. Mast, Alexey Eroshkin, Jeffrey W. Smith, W. Andy Tao, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2007) 407 (1): 41–48.
https://doi.org/10.1042/BJ20070775
Published: 12 September 2007
View articletitled, Profiling constitutive proteolytic events in vivo
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Includes: Supplementary data
Articles

Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)–mediated inhibition of caspase 9

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Jean-Bernard Denault, Brendan P. Eckelman, Hwain Shin, Cristina Pop, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2007) 405 (1): 11–19.
https://doi.org/10.1042/BJ20070288
Published: 13 June 2007
View articletitled, Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)–mediated inhibition of caspase 9
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Includes: Supplementary data
Articles

The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition

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Hwain SHIN, Martin RENATUS, Brendan P. ECKELMAN, Viviane A. NUNES, Claudio A. M. SAMPAIO, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 1–10.
https://doi.org/10.1042/BJ20041107
Published: 14 December 2004
View articletitled, The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
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Articles

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP

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Domagoj VUCIC, Matthew C. FRANKLIN, Heidi J. A. WALLWEBER, Kanad DAS, Brendan P. ECKELMAN, Hwain SHIN, Linda O. ELLIOTT, Saloumeh KADKHODAYAN, Kurt DESHAYES, Guy S. SALVESEN, Wayne J. FAIRBROTHER
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 11–20.
https://doi.org/10.1042/BJ20041108
Published: 14 December 2004
View articletitled, Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
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Articles

The protein structures that shape caspase activity, specificity, activation and inhibition

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Pablo FUENTES-PRIOR, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2004) 384 (2): 201–232.
https://doi.org/10.1042/BJ20041142
Published: 23 November 2004
View articletitled, The protein structures that shape caspase activity, specificity, activation and inhibition
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Includes: Supplementary data
Articles

Activation of caspases-8 and -10 by FLIP L

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Kelly M. BOATRIGHT, Cristina DEIS, Jean-Bernard DENAULT, Daniel P. SUTHERLIN, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2004) 382 (2): 651–657.
https://doi.org/10.1042/BJ20040809
Published: 24 August 2004
View articletitled, Activation of caspases-8 and -10 by FLIP L
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Articles

Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein

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Hwain SHIN, Kazuya OKADA, John C. WILKINSON, Katherine M. SOLOMON, Colin S. DUCKETT, John C. REED, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2003) 373 (3): 965–971.
https://doi.org/10.1042/bj20030583
Published: 01 August 2003
View articletitled, Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein
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Articles

Inhibitor specificity of recombinant and endogenous caspase-9

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Ciara A. RYAN, Henning R. STENNICKE, Victor E. NAVA, Jennifer B. BURCH, J. Marie HARDWICK, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2002) 366 (2): 595–601.
https://doi.org/10.1042/bj20020863
Published: 01 September 2002
View articletitled, Inhibitor specificity of recombinant and endogenous caspase-9
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Articles

Inhibition of distant caspase homologues by natural caspase inhibitors

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Scott J. SNIPAS, Henning R. STENNICKE, Stefan RIEDL, Jan POTEMPA, James TRAVIS, Alan J. BARRETT, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2001) 357 (2): 575–580.
https://doi.org/10.1042/bj3570575
Published: 09 July 2001
View articletitled, Inhibition of distant caspase homologues by natural caspase inhibitors
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Articles

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8

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Henning R. STENNICKE, Martin RENATUS, Morten MELDAL, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (2000) 350 (2): 563–568.
https://doi.org/10.1042/bj3500563
Published: 23 August 2000
View articletitled, Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
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Articles

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

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Qiao ZHOU, Guy S. SALVESEN
Journal: Biochemical Journal
Biochem J (1997) 324 (2): 361–364.
https://doi.org/10.1042/bj3240361
Published: 01 June 1997
View articletitled, Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity
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