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Hideaki Nagase
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Articles

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

Available to Purchase
Salvatore Santamaria, Kazuhiro Yamamoto, Kenneth Botkjaer, Christopher Tape, Michael R. Dyson, John McCafferty, Gillian Murphy, Hideaki Nagase
Journal: Biochemical Journal
Biochem J (2015) 471 (3): 391–401.
https://doi.org/10.1042/BJ20150758
Published: 16 October 2015
View articletitled, Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
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Includes: Supplementary data
Articles

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

Open Access
Linda Troeberg, Barbara Mulloy, Peter Ghosh, Meng-Huee Lee, Gillian Murphy, Hideaki Nagase
Journal: Biochemical Journal
Biochem J (2012) 443 (1): 307–315.
https://doi.org/10.1042/BJ20112159
Published: 14 March 2012
View articletitled, Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
Open the PDF for Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex in another window
Articles

Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer

Available to Purchase
Yoshifumi Itoh, Ralf Palmisano, Narayanapanicker Anilkumar, Hideaki Nagase, Atsushi Miyawaki, Motoharu Seiki
Journal: Biochemical Journal
Biochem J (2011) 440 (3): 319–327.
https://doi.org/10.1042/BJ20110424
Published: 28 November 2011
View articletitled, Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer
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Includes: Multimedia, Supplementary data
Articles

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

Open Access
Ngee H. Lim, Masahide Kashiwagi, Robert Visse, Jonathan Jones, Jan J. Enghild, Keith Brew, Hideaki Nagase
Journal: Biochemical Journal
Biochem J (2010) 431 (1): 113–122.
https://doi.org/10.1042/BJ20100725
Published: 14 September 2010
View articletitled, Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Open the PDF for Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications in another window
Articles

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

Available to Purchase
Marie Kveiborg, Jonas Jacobsen, Meng-Huee Lee, Hideaki Nagase, Ulla M. Wewer, Gillian Murphy
Journal: Biochemical Journal
Biochem J (2010) 430 (1): 79–86.
https://doi.org/10.1042/BJ20100649
Published: 28 July 2010
View articletitled, Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)
Open the PDF for Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2) in another window
Articles

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1

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Christian Ries, Thomas Pitsch, Reinhard Mentele, Stefan Zahler, Virginia Egea, Hideaki Nagase, Marianne Jochum
Journal: Biochemical Journal
Biochem J (2007) 405 (3): 547–558.
https://doi.org/10.1042/BJ20070191
Published: 13 July 2007
View articletitled, Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1
Open the PDF for Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1 in another window
Articles

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2

Available to Purchase
Wei-Man Wang, Gaoxiang Ge, N. H. Lim, Hideaki Nagase, Daniel S. Greenspan
Journal: Biochemical Journal
Biochem J (2006) 398 (3): 515–519.
https://doi.org/10.1042/BJ20060630
Published: 29 August 2006
View articletitled, TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2
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Articles

Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1)

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Hideaki NAGASE, Ko SUZUKI, Tim E. CAWSTON, K. BREW
Journal: Biochemical Journal
Biochem J (1997) 325 (1): 163–167.
https://doi.org/10.1042/bj3250163
Published: 01 July 1997
View articletitled, Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1)
Open the PDF for Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1) in another window