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Articles

Solution structures of the Bacillus cereus metallo-β-lactamase BcII and its complex with the broad spectrum inhibitor R -thiomandelic acid

Andreas Ioannis Karsisiotis, Christian F. Damblon, Gordon C. K. Roberts
Journal: Biochemical Journal
Biochem J (2013) 456 (3): 397–407.
https://doi.org/10.1042/BJ20131003
Published: 22 November 2013
View articletitled, Solution structures of the Bacillus cereus metallo-β-lactamase BcII and its complex with the broad spectrum inhibitor R -thiomandelic acid
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Includes: Supplementary data
Articles

Super toxins from a super bug: structure and function of Clostridium difficile toxins

Abigail H. Davies, April K. Roberts, Clifford C. Shone, K. Ravi Acharya
Journal: Biochemical Journal
Biochem J (2011) 436 (3): 517–526.
https://doi.org/10.1042/BJ20110106
Published: 27 May 2011
View articletitled, Super toxins from a super bug: structure and function of Clostridium difficile toxins
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Includes: Multimedia, Supplementary data
Articles

Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4

Yassar Farooq, Gordon C. K. Roberts
Journal: Biochemical Journal
Biochem J (2010) 432 (3): 485–494.
https://doi.org/10.1042/BJ20100744
Published: 25 November 2010
View articletitled, Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4
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Includes: Supplementary data
Articles

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite

Jack U. FLANAGAN, Jean-Didier MARÉCHAL, Richard WARD, Carol A. KEMP, Lesley A. McLAUGHLIN, Michael J. SUTCLIFFE, Gordon C. K. ROBERTS, Mark J. I. PAINE, C. Roland WOLF
Journal: Biochemical Journal
Biochem J (2004) 380 (2): 353–360.
https://doi.org/10.1042/bj20040062
Published: 01 June 2004
View articletitled, Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite
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Articles

The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases

Claire S. ALLARDYCE, Paul D. MCDONAGH, Lu-Yun LIAN, C. Roland WOLF, Gordon C. K. ROBERTS
Journal: Biochemical Journal
Biochem J (1999) 343 (3): 525–531.
https://doi.org/10.1042/bj3430525
Published: 25 October 1999
View articletitled, The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases
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Articles

Determinants of specificity for aflatoxin B1-8,9-epoxide in Alpha-class glutathione S-transferases

Paul D. McDONAGH, David J. JUDAH, John D. HAYES, Lu-Yun LIAN, Gordon E. NEAL, C. Roland WOLF, Gordon C. K. ROBERTS
Journal: Biochemical Journal
Biochem J (1999) 339 (1): 95–101.
https://doi.org/10.1042/bj3390095
Published: 25 March 1999
View articletitled, Determinants of specificity for aflatoxin B1-8,9-epoxide in Alpha-class glutathione S-transferases
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Articles

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

Gillian SMITH, Sandeep MODI, Ilona PILLAI, Lu-Yun LIAN, Michael J. SUTCLIFFE, Michael P. PRITCHARD, Thomas FRIEDBERG, Gordon C. K. ROBERTS, C. Roland WOLF
Journal: Biochemical Journal
Biochem J (1998) 331 (3): 783–792.
https://doi.org/10.1042/bj3310783
Published: 01 May 1998
View articletitled, Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity
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Articles

Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P -450 BM-3 on substrate binding and catalytic activity

S Modi, W U Primrose, L Y Lian, G C K Roberts
Journal: Biochemical Journal
Biochem J (1995) 310 (3): 939–943.
https://doi.org/10.1042/bj3100939
Published: 15 September 1995
View articletitled, Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P -450 BM-3 on substrate binding and catalytic activity
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Articles

Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice

R M A Bellingham, A H Gibbs, F de Matteis, L Y Lian, G C K Roberts
Journal: Biochemical Journal
Biochem J (1995) 307 (2): 505–512.
https://doi.org/10.1042/bj3070505
Published: 15 April 1995
View articletitled, Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice
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Articles

Changes in the structure of bovine phospholipase A 2 upon micelle binding

P M Kilby, W U Primrose, G C K Roberts
Journal: Biochemical Journal
Biochem J (1995) 305 (3): 935–944.
https://doi.org/10.1042/bj3050935
Published: 01 February 1995
View articletitled, Changes in the structure of bovine phospholipase A 2 upon micelle binding
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Articles

Direct n.m.r. evidence for substrate-induced conformational changes in a β -lactamase

M Jamin, C Damblon, A M Bauduin-Misselyn, F Durant, G C K Roberts, P Charlier, G Llabres, J M Frère
Journal: Biochemical Journal
Biochem J (1994) 301 (1): 199–203.
https://doi.org/10.1042/bj3010199
Published: 01 July 1994
View articletitled, Direct n.m.r. evidence for substrate-induced conformational changes in a β -lactamase
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Articles

A novel aldehyde reductase with activity towards a metabolite of aflatoxin B 1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

D J Judah, J D Hayes, J C Yang, L Y Lian, G C K Roberts, P B Farmer, J H Lamb, G E Neal
Journal: Biochemical Journal
Biochem J (1993) 292 (1): 13–18.
https://doi.org/10.1042/bj2920013
Published: 15 May 1993
View articletitled, A novel aldehyde reductase with activity towards a metabolite of aflatoxin B 1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
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Articles

A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633

W C Chan, B W Bycroft, M L Leyland, L Y Lian, G C K Roberts
Journal: Biochemical Journal
Biochem J (1993) 291 (1): 23–27.
https://doi.org/10.1042/bj2910023
Published: 01 April 1993
View articletitled, A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633
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Articles

The pattern of plant annexin gene expression

M F Smallwood, S J Gurr, M J McPherson, K Roberts, D J Bowles
Journal: Biochemical Journal
Biochem J (1992) 281 (2): 501–505.
https://doi.org/10.1042/bj2810501
Published: 15 January 1992
View articletitled, The pattern of plant annexin gene expression
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Articles

Interactions between inhibitors of dihydrofolate reductase

K Bowden, A D Hall, B Birdsall, J Feeney, G C K Roberts
Journal: Biochemical Journal
Biochem J (1989) 258 (2): 335–342.
https://doi.org/10.1042/bj2580335
Published: 01 March 1989
View articletitled, Interactions between inhibitors of dihydrofolate reductase
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Articles

A 1 H-n.m.r. study of casein micelles

M C A Griffin, G C K Roberts
Journal: Biochemical Journal
Biochem J (1985) 228 (1): 273–276.
https://doi.org/10.1042/bj2280273
Published: 15 May 1985
View articletitled, A 1 H-n.m.r. study of casein micelles
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Articles

An alternative procedure for incorporating radiolabelled cholesteryl ester into human plasma lipoproteins in vitro

D C K Roberts, N E Miller, S G L Price, D Crook, C Cortese, A La Ville, L Masana, B Lewis
Journal: Biochemical Journal
Biochem J (1985) 226 (1): 319–322.
https://doi.org/10.1042/bj2260319
Published: 15 February 1985
View articletitled, An alternative procedure for incorporating radiolabelled cholesteryl ester into human plasma lipoproteins in vitro
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Articles

19 F-n.m.r. studies of 3′,5′-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes

G M Clore, A M Gronenborn, B Birdsall, J Feeney, G C K Roberts
Journal: Biochemical Journal
Biochem J (1984) 217 (3): 659–666.
https://doi.org/10.1042/bj2170659
Published: 01 February 1984
View articletitled, 19 F-n.m.r. studies of 3′,5′-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes
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Articles

Domain structure and 1 H-n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Bacillus stearothermophilus

L C Packman, R N Perham, G C K Roberts
Journal: Biochemical Journal
Biochem J (1984) 217 (1): 219–227.
https://doi.org/10.1042/bj2170219
Published: 01 January 1984
View articletitled, Domain structure and 1 H-n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Bacillus stearothermophilus
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Articles

Identification by n.m.r. spectroscopy of a stable intermediate structure in the unfolding of staphylococcal β -lactamase

R M Thomas, J Feeney, R B Nicholson, R H Pain, G C K Roberts
Journal: Biochemical Journal
Biochem J (1983) 215 (3): 525–529.
https://doi.org/10.1042/bj2150525
Published: 01 December 1983
View articletitled, Identification by n.m.r. spectroscopy of a stable intermediate structure in the unfolding of staphylococcal β -lactamase
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Articles

Cross-linking and 1 H n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Escherichia coli

Leonard C. Packman, Richard N. Perham, Gordon C. K. Roberts
Journal: Biochemical Journal
Biochem J (1982) 205 (2): 389–396.
https://doi.org/10.1042/bj2050389
Published: 01 August 1982
View articletitled, Cross-linking and 1 H n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Escherichia coli
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Articles

Limited proteolysis and proton n.m.r. spectroscopy of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli

R N Perham, G C K Roberts
Journal: Biochemical Journal
Biochem J (1981) 199 (3): 733–740.
https://doi.org/10.1042/bj1990733
Published: 01 December 1981
View articletitled, Limited proteolysis and proton n.m.r. spectroscopy of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli
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Articles

Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase

K Hood, G C K Roberts
Journal: Biochemical Journal
Biochem J (1978) 171 (2): 357–366.
https://doi.org/10.1042/bj1710357
Published: 01 May 1978
View articletitled, Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase
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Articles

The combination of nuclear-magnetic-resonance spectroscopy and potential-energy calculations in the study of peptide conformation in solution

G C k Roberts, J Feeney
Journal: Biochemical Journal
Biochem J (1971) 125 (4): 88P–89P.
https://doi.org/10.1042/bj1250088P
Published: 01 December 1971
View articletitled, The combination of nuclear-magnetic-resonance spectroscopy and potential-energy calculations in the study of peptide conformation in solution
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Articles

Conformational studies of some hormonal peptides in solution by using nuclear-magnetic-resonance spectroscopy

J Feeney, G C K Roberts, A S V Burgen
Journal: Biochemical Journal
Biochem J (1971) 125 (3): 62P.
https://doi.org/10.1042/bj1250062Pa
Published: 01 December 1971
View articletitled, Conformational studies of some hormonal peptides in solution by using nuclear-magnetic-resonance spectroscopy
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Articles

The specific substance from Pneumococcus type 34 (41). The phosphodiester linkages

G. J. F. Chittenden, W. K. Roberts, J. G. Buchanan, J Baddiley
Journal: Biochemical Journal
Biochem J (1968) 109 (4): 597–602.
https://doi.org/10.1042/bj1090597
Published: 01 October 1968
View articletitled, The specific substance from Pneumococcus type 34 (41). The phosphodiester linkages
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