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Articles

Phosphoinositide 3-kinase: the key switch in insulin signalling

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P. R. SHEPHERD, D. J. WITHERS, K. SIDDLE
Journal: Biochemical Journal
Biochem J (1998) 335 (3): 711.
https://doi.org/10.1042/bj3350711u
Published: 01 November 1998
View articletitled, Phosphoinositide 3-kinase: the key switch in insulin signalling
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Articles

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

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P R Shepherd, B T Navé, K Siddle
Journal: Biochemical Journal
Biochem J (1995) 305 (1): 25–28.
https://doi.org/10.1042/bj3050025
Published: 01 January 1995
View articletitled, Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
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Articles

Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation

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M P Coghlan, T S Pillay, J M Tavaré, K Siddle
Journal: Biochemical Journal
Biochem J (1994) 303 (3): 893–899.
https://doi.org/10.1042/bj3030893
Published: 01 November 1994
View articletitled, Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation
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Articles

A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor

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C Alarcón, B Cheatham, B Lincoln, C R Kahn, K Siddle, C J Rhodes
Journal: Biochemical Journal
Biochem J (1994) 301 (1): 257–265.
https://doi.org/10.1042/bj3010257
Published: 01 July 1994
View articletitled, A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor
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Articles

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

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M A Soos, C E Field, K Siddle
Journal: Biochemical Journal
Biochem J (1993) 290 (2): 419–426.
https://doi.org/10.1042/bj2900419
Published: 01 March 1993
View articletitled, Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
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Articles

A monoclonal anti-peptide antibody reacting with the insulin receptor β -subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors

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R H Ganderton, K K Stanley, C E Field, M P Coghlan, M A Soos, K Siddle
Journal: Biochemical Journal
Biochem J (1992) 288 (1): 195–205.
https://doi.org/10.1042/bj2880195
Published: 15 November 1992
View articletitled, A monoclonal anti-peptide antibody reacting with the insulin receptor β -subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors
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Articles

Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase

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S Clark, G Eckardt, K Siddle, L C Harrison
Journal: Biochemical Journal
Biochem J (1991) 276 (1): 27–33.
https://doi.org/10.1042/bj2760027
Published: 15 May 1991
View articletitled, Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase
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Articles

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

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M A Soos, J Whittaker, R Lammers, A Ullrich, K Siddle
Journal: Biochemical Journal
Biochem J (1990) 270 (2): 383–390.
https://doi.org/10.1042/bj2700383
Published: 01 September 1990
View articletitled, Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells
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Articles

Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA

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N P J Brindle, J M Tavare, M Dickens, J Whittaker, K Siddle
Journal: Biochemical Journal
Biochem J (1990) 268 (3): 615–620.
https://doi.org/10.1042/bj2680615
Published: 15 June 1990
View articletitled, Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA
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Articles

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

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M A Soos, K Siddle
Journal: Biochemical Journal
Biochem J (1989) 263 (2): 553–563.
https://doi.org/10.1042/bj2630553
Published: 15 October 1989
View articletitled, Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors
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Articles

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

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W J Sobey, S F Beer, C A Carrington, P M S Clark, B H Frank, I P Gray, S D Luzio, D R Owens, A E Schneider, K Siddle, R C Temple, C N Hales
Journal: Biochemical Journal
Biochem J (1989) 260 (2): 535–541.
https://doi.org/10.1042/bj2600535
Published: 01 June 1989
View articletitled, Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins
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Articles

Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping

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J M Tavaré, R M O'Brien, K Siddle, R M Denton
Journal: Biochemical Journal
Biochem J (1988) 253 (3): 783–788.
https://doi.org/10.1042/bj2530783
Published: 01 August 1988
View articletitled, Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping
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Articles

Production and characterization of monoclonal antibodies to insulin secretory granule membranes

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K A Grimaldi, J C Hutton, K Siddle
Journal: Biochemical Journal
Biochem J (1987) 245 (2): 557–566.
https://doi.org/10.1042/bj2450557
Published: 15 July 1987
View articletitled, Production and characterization of monoclonal antibodies to insulin secretory granule membranes
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Articles

Biosynthesis of insulin secretory granule membrane proteins. Control by glucose

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K A Grimaldi, K Siddle, J C Hutton
Journal: Biochemical Journal
Biochem J (1987) 245 (2): 567–573.
https://doi.org/10.1042/bj2450567
Published: 15 July 1987
View articletitled, Biosynthesis of insulin secretory granule membrane proteins. Control by glucose
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Articles

The preparation of monoclonal antibodies to human bone and liver alkaline phosphatase and their use in immunoaffinity purification and in studying these enzymes when present in serum

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E M Bailyes, R N Seabrook, J Calvin, G A Maguire, C P Price, K Siddle, J P Luzio
Journal: Biochemical Journal
Biochem J (1987) 244 (3): 725–733.
https://doi.org/10.1042/bj2440725
Published: 15 June 1987
View articletitled, The preparation of monoclonal antibodies to human bone and liver alkaline phosphatase and their use in immunoaffinity purification and in studying these enzymes when present in serum
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Articles

Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor

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R Taylor, M A Soos, A Wells, M Argyraki, K Siddle
Journal: Biochemical Journal
Biochem J (1987) 242 (1): 123–129.
https://doi.org/10.1042/bj2420123
Published: 15 February 1987
View articletitled, Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor
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Articles

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

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M A Soos, K Siddle, M D Baron, J M Heward, J P Luzio, J Bellatin, E S Lennox
Journal: Biochemical Journal
Biochem J (1986) 235 (1): 199–208.
https://doi.org/10.1042/bj2350199
Published: 01 April 1986
View articletitled, Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor
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Articles

The existence and properties of two dimers of rat liver ecto-5′-nucleotidase

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E M Bailyes, M Soos, P Jackson, A C Newby, K Siddle, J P Luzio
Journal: Biochemical Journal
Biochem J (1984) 221 (2): 369–377.
https://doi.org/10.1042/bj2210369
Published: 15 July 1984
View articletitled, The existence and properties of two dimers of rat liver ecto-5′-nucleotidase
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Articles

Immunoaffinity purification of intact, metabolically active, cholinergic nerve terminals from mammalian brain

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P J Richardson, K Siddle, J P Luzio
Journal: Biochemical Journal
Biochem J (1984) 219 (2): 647–654.
https://doi.org/10.1042/bj2190647
Published: 15 April 1984
View articletitled, Immunoaffinity purification of intact, metabolically active, cholinergic nerve terminals from mammalian brain
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Articles

A monoclonal antibody to human brain-type creatine kinase. Increased avidity with mercaptans

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A P Jackson, K Siddle, R J Thompson
Journal: Biochemical Journal
Biochem J (1983) 215 (3): 505–512.
https://doi.org/10.1042/bj2150505
Published: 01 December 1983
View articletitled, A monoclonal antibody to human brain-type creatine kinase. Increased avidity with mercaptans
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Articles

Solubilization and purification of rat liver 5′-nucleotidase by use of a zwitterionic detergent and a monoclonal-antibody immunoadsorbent

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E M Bailyes, A C Newby, K Siddle, J P Luzio
Journal: Biochemical Journal
Biochem J (1982) 203 (1): 245–251.
https://doi.org/10.1042/bj2030245
Published: 01 April 1982
View articletitled, Solubilization and purification of rat liver 5′-nucleotidase by use of a zwitterionic detergent and a monoclonal-antibody immunoadsorbent
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Articles

The effect of intracellular calcium ions on adrenaline-stimulated adenosine 3′:5′-cyclic monophosphate concentrations in pigeon erythrocytes, studied by using the ionophore A23187

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A K Campbell, K Siddle
Journal: Biochemical Journal
Biochem J (1976) 158 (2): 211–221.
https://doi.org/10.1042/bj1580211
Published: 15 August 1976
View articletitled, The effect of intracellular calcium ions on adrenaline-stimulated adenosine 3′:5′-cyclic monophosphate concentrations in pigeon erythrocytes, studied by using the ionophore A23187
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Articles

The effect of local anaesthetics on lipolysis in fat-cells

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K Siddle, C N Hales
Journal: Biochemical Journal
Biochem J (1972) 130 (1): 34P.
https://doi.org/10.1042/bj1300034P
Published: 01 November 1972
View articletitled, The effect of local anaesthetics on lipolysis in fat-cells
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Articles

The effect of glucagon on adenosine 3':5'-cyclic monophosphate concentrations in an organ culture of adult rat liver

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A K Campbell, K Siddle
Journal: Biochemical Journal
Biochem J (1972) 130 (1): 15P–16P.
https://doi.org/10.1042/bj1300015Pb
Published: 01 November 1972
View articletitled, The effect of glucagon on adenosine 3':5'-cyclic monophosphate concentrations in an organ culture of adult rat liver
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