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Luiz JULIANO
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Articles

Transthyretin is a metallopeptidase with an inducible active site

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Márcia A. Liz, Sérgio C. Leite, Luiz Juliano, Maria J. Saraiva, Ana M. Damas, Daniel Bur, Mónica M. Sousa
Journal: Biochemical Journal
Biochem J (2012) 443 (3): 769–778.
https://doi.org/10.1042/BJ20111690
Published: 16 April 2012
View articletitled, Transthyretin is a metallopeptidase with an inducible active site
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Includes: Supplementary data
Articles

The role of Tyr 605 and Ala 607 of thimet oligopeptidase and Tyr 606 and Gly 608 of neurolysin in substrate hydrolysis and inhibitor binding

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Maurício F. M. Machado, Vanessa Rioli, Fernanda M. Dalio, Leandro M. Castro, Maria A. Juliano, Ivarne L. Tersariol, Emer S. Ferro, Luiz Juliano, Vitor Oliveira
Journal: Biochemical Journal
Biochem J (2007) 404 (2): 279–288.
https://doi.org/10.1042/BJ20070060
Published: 14 May 2007
View articletitled, The role of Tyr 605 and Ala 607 of thimet oligopeptidase and Tyr 606 and Gly 608 of neurolysin in substrate hydrolysis and inhibitor binding
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Articles

Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates

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Giuseppe MOLINARO, Adriana K. CARMONA, Maria A. JULIANO, Luiz JULIANO, Elena MALITSKAYA, Marie-Andrée YESSINE, Miguel CHAGNON, Yves LEPAGE, William H. SIMMONS, Guy BOILEAU, Albert ADAM
Journal: Biochemical Journal
Biochem J (2005) 385 (2): 389–397.
https://doi.org/10.1042/BJ20040849
Published: 07 January 2005
View articletitled, Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates
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Articles

Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins

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Sandro E. FOGAÇA, Robson L. MELO, Daniel C. PIMENTA, Kazuo HOSOI, Luiz JULIANO, Maria A. JULIANO
Journal: Biochemical Journal
Biochem J (2004) 380 (3): 775–781.
https://doi.org/10.1042/bj20031047
Published: 15 June 2004
View articletitled, Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
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Articles

S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates

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Marcio F. M. ALVES, Luciano PUZER, Simone S. COTRIN, Maria Aparecida JULIANO, Luiz JULIANO, Dieter BRÖMME, Adriana K. CARMONA
Journal: Biochemical Journal
Biochem J (2003) 373 (3): 981–986.
https://doi.org/10.1042/bj20030438
Published: 01 August 2003
View articletitled, S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates
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Articles

Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity

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Jefferson P. HEMERLY, Vitor OLIVEIRA, Elaine DEL NERY, Rory E. MORTY, Norma W. ANDREWS, Maria A. JULIANO, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (2003) 373 (3): 933–939.
https://doi.org/10.1042/bj20030342
Published: 01 August 2003
View articletitled, Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity
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Articles

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

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Marcelo CAMPOS, Constance COUTURE, Izaura Y. HIRATA, Maria A. JULIANO, Thomas P. LOISEL, Philippe CRINE, Luiz JULIANO, Guy BOILEAU, Adriana K. CARMONA
Journal: Biochemical Journal
Biochem J (2003) 373 (1): 271–279.
https://doi.org/10.1042/bj20030287
Published: 01 July 2003
View articletitled, Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein
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Articles

Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors

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Daniel C. PIMENTA, Sandro E. FOGAÇA, Robson L. MELO, Luiz JULIANO, Maria A. JULIANO
Journal: Biochemical Journal
Biochem J (2003) 371 (3): 1021–1025.
https://doi.org/10.1042/bj20021952
Published: 01 May 2003
View articletitled, Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors
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Articles

Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides

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Maria Helena S. CEZARI, Luciano PUZER, Maria Aparecida JULIANO, Adriana K. CARMONA, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (2002) 368 (1): 365–369.
https://doi.org/10.1042/bj20020840
Published: 15 November 2002
View articletitled, Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides
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Articles

Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates

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Sylvie ATTUCCI, Brice KORKMAZ, Luiz JULIANO, Eric HAZOUARD, Catherine GIRARDIN, Michèle BRILLARD-BOURDET, Sophie RÉHAULT, Philippe ANTHONIOZ, Francis GAUTHIER
Journal: Biochemical Journal
Biochem J (2002) 366 (3): 965–970.
https://doi.org/10.1042/bj20020321
Published: 15 September 2002
View articletitled, Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates
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Articles

Interaction of heparin with internally quenched fluorogenic peptides derived from heparin-binding consensus sequences, kallistatin and anti-thrombin III

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Daniel C. PIMENTA, Iseli L. NANTES, Eduardo S. de SOUZA, Bernard Le BONNIEC, Amando S. ITO, Ivarne L.S. TERSARIOL, Vitor OLIVEIRA, Maria A. JULIANO, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (2002) 366 (2): 435–446.
https://doi.org/10.1042/bj20020023
Published: 01 September 2002
View articletitled, Interaction of heparin with internally quenched fluorogenic peptides derived from heparin-binding consensus sequences, kallistatin and anti-thrombin III
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Articles

Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana

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Sanya J. SANDERSON, Kevin G. J. POLLOCK, James D. HILLEY, Morten MELDAL, Phaedria ST HILAIRE, Maria A. JULIANO, Luiz JULIANO, Jeremy C. MOTTRAM, Graham H. COOMBS
Journal: Biochemical Journal
Biochem J (2000) 347 (2): 383–388.
https://doi.org/10.1042/bj3470383
Published: 10 April 2000
View articletitled, Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana
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Articles

Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2′ and P3′ variations in extended substrates

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Fernada C. Vieira PORTARO, Ana Beatriz F. SANTOS, Maria Helena S. CEZARI, Maria Aparecida JULIANO, Luiz JULIANO, Euridice CARMONA
Journal: Biochemical Journal
Biochem J (2000) 347 (1): 123–129.
https://doi.org/10.1042/bj3470123
Published: 27 March 2000
View articletitled, Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2′ and P3′ variations in extended substrates
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Articles

Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1

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M. Kerstin HENKEL, Gregory POTT, Andreas W. HENKEL, Luiz JULIANO, Chih-Min KAM, James C. POWERS, Alex FRANZUSOFF
Journal: Biochemical Journal
Biochem J (1999) 341 (2): 445–452.
https://doi.org/10.1042/bj3410445
Published: 08 July 1999
View articletitled, Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1
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Articles

Specificity of human tissue kallikrein towards substrates containing Phe–Phe pair of amino acids

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Daniel C. PIMENTA, Julie CHAO, Lee CHAO, Maria A. JULIANO, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (1999) 339 (2): 473–479.
https://doi.org/10.1042/bj3390473
Published: 08 April 1999
View articletitled, Specificity of human tissue kallikrein towards substrates containing Phe–Phe pair of amino acids
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Articles

Hydrolysis of somatostatin by human tissue kallikrein after the amino acid pair Phe-Phe

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Daniel C. PIMENTA, Maria A. JULIANO, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (1997) 327 (1): 27–30.
https://doi.org/10.1042/bj3270027
Published: 01 October 1997
View articletitled, Hydrolysis of somatostatin by human tissue kallikrein after the amino acid pair Phe-Phe
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Articles

Structural features that make oligopeptides susceptible substrates for hydrolysis by recombinant thimet oligopeptidase

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Antonio. C. M CAMARGO, Marcelo. D GOMES, Antonia. P REICHL, Emer. S FERRO, Saul JACCHIERI, Isaura. Y HIRATA, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (1997) 324 (2): 517–522.
https://doi.org/10.1042/bj3240517
Published: 01 June 1997
View articletitled, Structural features that make oligopeptides susceptible substrates for hydrolysis by recombinant thimet oligopeptidase
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Articles

Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides

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Elaine DEL NERY, Maria A. JULIANO, Morten MELDAL, Ib SVENDSEN, Julio SCHARFSTEIN, Adrian WALMSLEY, Luiz JULIANO
Journal: Biochemical Journal
Biochem J (1997) 323 (2): 427–433.
https://doi.org/10.1042/bj3230427
Published: 15 April 1997
View articletitled, Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides
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Articles

Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites

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Fernanda. C. V. PORTARO, Maria H. S. CEZARI, Maria A. JULIANO, Luiz JULIANO, Adrian R. WALMSLEY, Eline S. PRADO
Journal: Biochemical Journal
Biochem J (1997) 323 (1): 167–171.
https://doi.org/10.1042/bj3230167
Published: 01 April 1997
View articletitled, Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites
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Articles

Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi , through the use of cystatin-derived substrates and inhibitors

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Carole SERVEAU, Gilles LALMANACH, Maria A. JULIANO, Julio SCHARFSTEIN, Luiz JULIANO, Francis GAUTHIER
Journal: Biochemical Journal
Biochem J (1996) 313 (3): 951–956.
https://doi.org/10.1042/bj3130951
Published: 01 February 1996
View articletitled, Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi , through the use of cystatin-derived substrates and inhibitors
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Articles

Inhibition of renin by conformationally restricted analogues of angiotensinogen

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Clovis R. Nakaie, Maria C. F. Oliveira, Luiz Juliano, Antonio C. M. Paiva
Journal: Biochemical Journal
Biochem J (1982) 205 (1): 43–47.
https://doi.org/10.1042/bj2050043
Published: 01 July 1982
View articletitled, Inhibition of renin by conformationally restricted analogues of angiotensinogen
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