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M D Houslay
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Articles

Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C

L Zeng, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 312 (3): 769–774.
https://doi.org/10.1042/bj3120769
Published: 15 December 1995
View article titled, Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C
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Articles

Induction of Ca 2+ /calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms

S Spence, G Rena, G Sweeney, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 310 (3): 975–982.
https://doi.org/10.1042/bj3100975
Published: 15 September 1995
View article titled, Induction of Ca 2+ /calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms
Open the PDF for Induction of Ca 2+ /calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms in another window
Articles

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

I McPhee, L Pooley, M Lobban, G Bolger, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 310 (3): 965–974.
https://doi.org/10.1042/bj3100965
Published: 15 September 1995
View article titled, Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family
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Articles

Insulin inhibits the phosphorylation of α -G i -2 in intact hepatocytes

N J Morris, P Young, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 308 (2): 693–696.
https://doi.org/10.1042/bj3080693
Published: 01 June 1995
View article titled, Insulin inhibits the phosphorylation of α -G i -2 in intact hepatocytes
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Articles

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IV A1 ) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

G Scotland, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 308 (2): 673–681.
https://doi.org/10.1042/bj3080673
Published: 01 June 1995
View article titled, Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IV A1 ) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase
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Articles

Molecular cloning of a novel splice variant of human type IV A (PDE-IV A ) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19

Y M Horton, M Sullivan, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 308 (2): 683–691.
https://doi.org/10.1042/bj3080683
Published: 01 June 1995
View article titled, Molecular cloning of a novel splice variant of human type IV A (PDE-IV A ) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19
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Articles

Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue

R G Vernon, R Doris, E Finley, M D Houslay, E Kilgour, S Lindsay-Watt
Journal: Biochemical Journal
Biochem J (1995) 308 (1): 291–296.
https://doi.org/10.1042/bj3080291
Published: 15 May 1995
View article titled, Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue
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Articles

A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes

A Savage, L Zeng, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 307 (1): 281–285.
https://doi.org/10.1042/bj3070281
Published: 01 April 1995
View article titled, A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes
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Articles

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

Y Shakur, M Wilson, L Pooley, M Lobban, S L Griffiths, A M Campbell, J Beattie, C Daly, M D Houslay
Journal: Biochemical Journal
Biochem J (1995) 306 (3): 801–809.
https://doi.org/10.1042/bj3060801
Published: 15 March 1995
View article titled, Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum
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Articles

Identification of two splice variant forms of type-IV B cyclic AMP phosphodiesterase, DPD (rPDE-IV B1 ) and PDE-4 (rPDE-IV B2 ) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

M Lobban, Y Shakur, J Beattie, M D Houslay
Journal: Biochemical Journal
Biochem J (1994) 304 (2): 399–406.
https://doi.org/10.1042/bj3040399
Published: 01 December 1994
View article titled, Identification of two splice variant forms of type-IV B cyclic AMP phosphodiesterase, DPD (rPDE-IV B1 ) and PDE-4 (rPDE-IV B2 ) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions
Open the PDF for Identification of two splice variant forms of type-IV B cyclic AMP phosphodiesterase, DPD (rPDE-IV B1 ) and PDE-4 (rPDE-IV B2 ) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions in another window
Articles

Purification, characterization and analysis of rolipram inhibition of a human type-IV A cyclic AMP-specific phosphodiesterase expressed in yeast

M Wilson, M Sullivan, N Brown, M D Houslay
Journal: Biochemical Journal
Biochem J (1994) 304 (2): 407–415.
https://doi.org/10.1042/bj3040407
Published: 01 December 1994
View article titled, Purification, characterization and analysis of rolipram inhibition of a human type-IV A cyclic AMP-specific phosphodiesterase expressed in yeast
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Articles

Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein G i -2 occurs in intact rat hepatocytes

N J Morris, M Bushfield, B E Lavan, M D Houslay
Journal: Biochemical Journal
Biochem J (1994) 301 (3): 693–702.
https://doi.org/10.1042/bj3010693
Published: 01 August 1994
View article titled, Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein G i -2 occurs in intact rat hepatocytes
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Articles

Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells)

C Livingstone, C MacDonald, B Willett, M D Houslay
Journal: Biochemical Journal
Biochem J (1994) 300 (3): 835–842.
https://doi.org/10.1042/bj3000835
Published: 15 June 1994
View article titled, Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells)
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Articles

Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity.

M K Saville, M D Houslay
Journal: Biochemical Journal
Biochem J (1994) 299 (3): 863–868.
https://doi.org/10.1042/bj2990863
Published: 01 May 1994
View article titled, Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity.
Articles

Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of G i 2 in rat adipocytes

R Doris, R G Vernon, M D Houslay, E Kilgour
Journal: Biochemical Journal
Biochem J (1994) 297 (1): 41–45.
https://doi.org/10.1042/bj2970041
Published: 01 January 1994
View article titled, Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of G i 2 in rat adipocytes
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Articles

A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor

M Bushfield, A Savage, N J Morris, M D Houslay
Journal: Biochemical Journal
Biochem J (1993) 293 (1): 229–236.
https://doi.org/10.1042/bj2930229
Published: 01 July 1993
View article titled, A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor
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Articles

Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes

F Irvine, A V Wallace, S R Sarawak, M D Houslay
Journal: Biochemical Journal
Biochem J (1993) 293 (1): 249–253.
https://doi.org/10.1042/bj2930249
Published: 01 July 1993
View article titled, Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes
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Articles

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

Y Shakur, J G Pryde, M D Houslay
Journal: Biochemical Journal
Biochem J (1993) 292 (3): 677–686.
https://doi.org/10.1042/bj2920677
Published: 15 June 1993
View article titled, Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram
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Articles

The role of G i and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5′-imidodiphosphate

S Spence, M D Houslay
Journal: Biochemical Journal
Biochem J (1993) 291 (3): 945–949.
https://doi.org/10.1042/bj2910945
Published: 01 May 1993
View article titled, The role of G i and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5′-imidodiphosphate
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Articles

Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity

E K Tang, M D Houslay
Journal: Biochemical Journal
Biochem J (1992) 283 (2): 341–346.
https://doi.org/10.1042/bj2830341
Published: 15 April 1992
View article titled, Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity
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Articles

Regulation of cardiac adenylate cyclase activity in rodent models of obesity

D Strassheim, M D Houslay, G Milligan
Journal: Biochemical Journal
Biochem J (1992) 283 (1): 203–208.
https://doi.org/10.1042/bj2830203
Published: 01 April 1992
View article titled, Regulation of cardiac adenylate cyclase activity in rodent models of obesity
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Articles

Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese ( fa / fa ) Zucker rats

D Strassheim, T Palmer, G Milligan, M D Houslay
Journal: Biochemical Journal
Biochem J (1991) 276 (1): 197–202.
https://doi.org/10.1042/bj2760197
Published: 15 May 1991
View article titled, Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese ( fa / fa ) Zucker rats
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Articles

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein G i 2

M Bushfield, B E Lavan, M D Houslay
Journal: Biochemical Journal
Biochem J (1991) 274 (2): 317–321.
https://doi.org/10.1042/bj2740317
Published: 01 March 1991
View article titled, Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein G i 2
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Articles

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein G i -2 in hepatocytes

M Bushfield, S L Griffiths, G J Murphy, N J Pyne, J T Knowler, G Milligan, P J Parker, S Mollner, M D Houslay
Journal: Biochemical Journal
Biochem J (1990) 271 (2): 365–372.
https://doi.org/10.1042/bj2710365
Published: 15 October 1990
View article titled, Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein G i -2 in hepatocytes
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Articles

Hormonal regulation of G i 2 α -subunit phosphorylation in intact hepatocytes

M Bushfield, G J Murphy, B E Lavan, P J Parker, V J Hruby, G Milligan, M D Houslay
Journal: Biochemical Journal
Biochem J (1990) 268 (2): 449–457.
https://doi.org/10.1042/bj2680449
Published: 01 June 1990
View article titled, Hormonal regulation of G i 2 α -subunit phosphorylation in intact hepatocytes
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Articles

Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (G i ) on adipocyte adenylate cyclase activity

D Strassheim, G Milligan, M D Houslay
Journal: Biochemical Journal
Biochem J (1990) 266 (2): 521–526.
https://doi.org/10.1042/bj2660521
Published: 01 March 1990
View article titled, Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (G i ) on adipocyte adenylate cyclase activity
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Articles

The local anaesthetic benzyl alcohol attenuates the α 2 -adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E 1 , but not that stimulated by forskolin

S Spence, M D Houslay
Journal: Biochemical Journal
Biochem J (1989) 264 (2): 483–488.
https://doi.org/10.1042/bj2640483
Published: 01 December 1989
View article titled, The local anaesthetic benzyl alcohol attenuates the α 2 -adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E 1 , but not that stimulated by forskolin
Open the PDF for The local anaesthetic benzyl alcohol attenuates the α 2 -adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E 1 , but not that stimulated by forskolin in another window
Articles

Adipocyte plasma-membrane G i and G s in insulinopenic diabetic patients

J J Ohisalo, H L Vikman, S Ranta, M D Houslay, G Milligan
Journal: Biochemical Journal
Biochem J (1989) 264 (1): 289–292.
https://doi.org/10.1042/bj2640289
Published: 15 November 1989
View article titled, Adipocyte plasma-membrane G i and G s in insulinopenic diabetic patients
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Articles

Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase

N G Anderson, E Kilgour, M D Houslay
Journal: Biochemical Journal
Biochem J (1989) 262 (3): 867–872.
https://doi.org/10.1042/bj2620867
Published: 15 September 1989
View article titled, Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase
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Articles

Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to G i 1, G i 2 and G i 3

F M Mitchell, S L Griffiths, E D Saggerson, M D Houslay, J T Knowler, G Milligan
Journal: Biochemical Journal
Biochem J (1989) 262 (2): 403–408.
https://doi.org/10.1042/bj2620403
Published: 01 September 1989
View article titled, Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to G i 1, G i 2 and G i 3
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Articles

Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes

N J Pyne, W Cushley, H G Nimmo, M D Houslay
Journal: Biochemical Journal
Biochem J (1989) 261 (3): 897–904.
https://doi.org/10.1042/bj2610897
Published: 01 August 1989
View article titled, Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes
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Articles

Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N- ras proto-oncogene

A C Lloyd, S A Davies, I Crossley, M Whitaker, M D Houslay, A Hall, C J Marshall, M J Wakelam
Journal: Biochemical Journal
Biochem J (1989) 260 (3): 813–819.
https://doi.org/10.1042/bj2600813
Published: 15 June 1989
View article titled, Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N- ras proto-oncogene
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Articles

Activation and phosphorylation of the ‘dense-vesicle’ high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase

E Kilgour, N G Anderson, M D Houslay
Journal: Biochemical Journal
Biochem J (1989) 260 (1): 27–36.
https://doi.org/10.1042/bj2600027
Published: 15 May 1989
View article titled, Activation and phosphorylation of the ‘dense-vesicle’ high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase
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Articles

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein G i , which is inactivated upon challenge of hepatocytes with glucagon

G J Murphy, D J Gawler, G Milligan, M J O Wakelam, N J Pyne, M D Houslay
Journal: Biochemical Journal
Biochem J (1989) 259 (1): 191–197.
https://doi.org/10.1042/bj2590191
Published: 01 April 1989
View article titled, Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein G i , which is inactivated upon challenge of hepatocytes with glucagon
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Articles

Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes

F J Irvine, M D Houslay
Journal: Biochemical Journal
Biochem J (1988) 251 (2): 447–452.
https://doi.org/10.1042/bj2510447
Published: 15 April 1988
View article titled, Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes
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Articles

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein G i

D Gawler, G Milligan, M D Houslay
Journal: Biochemical Journal
Biochem J (1988) 249 (2): 537–542.
https://doi.org/10.1042/bj2490537
Published: 15 January 1988
View article titled, Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein G i
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Articles

Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values

G J Murphy, M D Houslay
Journal: Biochemical Journal
Biochem J (1988) 249 (2): 543–547.
https://doi.org/10.1042/bj2490543
Published: 15 January 1988
View article titled, Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values
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Articles

Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated ‘dense-vesicle’ and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat

N J Pyne, N Anderson, B E Lavan, G Milligan, H G Nimmo, M D Houslay
Journal: Biochemical Journal
Biochem J (1987) 248 (3): 897–901.
https://doi.org/10.1042/bj2480897
Published: 15 December 1987
View article titled, Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated ‘dense-vesicle’ and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat
Open the PDF for Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated ‘dense-vesicle’ and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat in another window
Articles

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism

G J Murphy, V J Hruby, D Trivedi, M J O Wakelam, M D Houslay
Journal: Biochemical Journal
Biochem J (1987) 243 (1): 39–46.
https://doi.org/10.1042/bj2430039
Published: 01 April 1987
View article titled, The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism
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Articles

The insulin- and glucagon-stimulated ‘dense-vesicle’ high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity

N J Pyne, M E Cooper, M D Houslay
Journal: Biochemical Journal
Biochem J (1987) 242 (1): 33–42.
https://doi.org/10.1042/bj2420033
Published: 15 February 1987
View article titled, The insulin- and glucagon-stimulated ‘dense-vesicle’ high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity
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Articles

Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets

M D Houslay, D Bojanic, D Gawler, S O'Hagan, A Wilson
Journal: Biochemical Journal
Biochem J (1986) 238 (1): 109–113.
https://doi.org/10.1042/bj2380109
Published: 15 August 1986
View article titled, Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets
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Articles

Acidic phospholipid species inhibit adenylate cyclase activity in rat liver plasma membranes

M D Houslay, L Needham, N J Dodd, A M Grey
Journal: Biochemical Journal
Biochem J (1986) 235 (1): 237–243.
https://doi.org/10.1042/bj2350237
Published: 01 April 1986
View article titled, Acidic phospholipid species inhibit adenylate cyclase activity in rat liver plasma membranes
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Articles

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

C M Heyworth, A M Grey, S R Wilson, E Hanski, M D Houslay
Journal: Biochemical Journal
Biochem J (1986) 235 (1): 145–149.
https://doi.org/10.1042/bj2350145
Published: 01 April 1986
View article titled, The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes
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Articles

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, N s and N i

M D Houslay, D Bojanic, A Wilson
Journal: Biochemical Journal
Biochem J (1986) 234 (3): 737–740.
https://doi.org/10.1042/bj2340737
Published: 15 March 1986
View article titled, Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, N s and N i
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Articles

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver

N J Pyne, M E Cooper, M D Houslay
Journal: Biochemical Journal
Biochem J (1986) 234 (2): 325–334.
https://doi.org/10.1042/bj2340325
Published: 01 March 1986
View article titled, Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver
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Articles

Insulin inhibits the cholera-toxin-catalysed ribosylation of a M r -25000 protein in rat liver plasma membranes

C M Heyworth, A D Whetton, S Wong, B R Martin, M D Houslay
Journal: Biochemical Journal
Biochem J (1985) 228 (3): 593–603.
https://doi.org/10.1042/bj2280593
Published: 15 June 1985
View article titled, Insulin inhibits the cholera-toxin-catalysed ribosylation of a M r -25000 protein in rat liver plasma membranes
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Articles

N 6 -(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes

A V Wallace, C M Heyworth, M D Houslay
Journal: Biochemical Journal
Biochem J (1984) 222 (1): 177–182.
https://doi.org/10.1042/bj2220177
Published: 15 August 1984
View article titled, N 6 -(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes
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Articles

An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations

C M Heyworth, A V Wallace, S R Wilson, M D Houslay
Journal: Biochemical Journal
Biochem J (1984) 222 (1): 183–187.
https://doi.org/10.1042/bj2220183
Published: 15 August 1984
View article titled, An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations
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Articles

Islet-activating protein blocks glucagon desensitization in intact hepatocytes

C M Heyworth, E Hanski, M D Houslay
Journal: Biochemical Journal
Biochem J (1984) 222 (1): 189–194.
https://doi.org/10.1042/bj2220189
Published: 15 August 1984
View article titled, Islet-activating protein blocks glucagon desensitization in intact hepatocytes
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Articles

Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes

S R Wilson, A V Wallace, M D Houslay
Journal: Biochemical Journal
Biochem J (1983) 216 (1): 245–248.
https://doi.org/10.1042/bj2160245
Published: 15 October 1983
View article titled, Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes
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