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Articles

Structural and kinetic characterization of an acetoacetyl-Coenzyme A: acetate Coenzyme A transferase from the extreme thermophile Thermosipho melanesiensis

Ryan G. Bing, Greg K. Buhrman, Kathryne C. Ford, Christopher T. Straub, Tunyaboon Laemthong, Robert B. Rose, Michael W.W. Adams, Robert M. Kelly

Biochem J (2025) 482 (04): 225–240.

https://doi.org/10.1042/BCJ20240747

Published: 18 February 2025

View article titled, Structural and kinetic characterization of an acetoacetyl-Coenzyme A: acetate Coenzyme A transferase from the extreme thermophile Thermosipho melanesiensis

Includes: Supplementary data

Articles

Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I)

Shreenal Patel, Syeed Hussain, Richard Harris, Sunita Sardiwal, John M. Kelly, Shane R. Wilkinson, Paul C. Driscoll, Snezana Djordjevic

Biochem J (2010) 425 (3): 513–522.

https://doi.org/10.1042/BJ20091167

Published: 15 January 2010

View article titled, Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I)

Includes: Supplementary data

Articles

The molecular basis of the effect of temperature on enzyme activity

Roy M. Daniel, Michelle E. Peterson, Michael J. Danson, Nicholas C. Price, Sharon M. Kelly, Colin R. Monk, Cristina S. Weinberg, Matthew L. Oudshoorn, Charles K. Lee

Biochem J (2010) 425 (2): 353–360.

https://doi.org/10.1042/BJ20091254

Published: 23 December 2009

View article titled, The molecular basis of the effect of temperature on enzyme activity

Articles

Characterization of two distinct binding modes between syntaxin 4 and Munc18c

Veronica Aran, Fiona M. Brandie, Alasdair R. Boyd, Theodoros Kantidakis, Elizabeth J. Rideout, Sharon M. Kelly, Gwyn W. Gould, Nia J. Bryant

Biochem J (2009) 419 (3): 655–660.

https://doi.org/10.1042/BJ20082293

Published: 14 April 2009

View article titled, Characterization of two distinct binding modes between syntaxin 4 and Munc18c

Articles

Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution

Ronan M. Kelly, Hans Leemhuis, Henriëtte J. Rozeboom, Niels van Oosterwijk, Bauke W. Dijkstra, Lubbert Dijkhuizen

Biochem J (2008) 413 (3): 517–525.

https://doi.org/10.1042/BJ20080353

Published: 15 July 2008

View article titled, Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution

Articles

Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite

Lucía Piacenza, Gonzalo Peluffo, María Noel Alvarez, John M. Kelly, Shane R. Wilkinson, Rafael Radi

Biochem J (2008) 410 (2): 359–368.

https://doi.org/10.1042/BJ20071138

Published: 12 February 2008

View article titled, Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite

Includes: Supplementary data

Articles

Validation of spermidine synthase as a drug target in African trypanosomes

Martin C. Taylor, Harparkash Kaur, Bernard Blessington, John M. Kelly, Shane R. Wilkinson

Biochem J (2008) 409 (2): 563–569.

https://doi.org/10.1042/BJ20071185

Published: 21 December 2007

View article titled, Validation of spermidine synthase as a drug target in African trypanosomes

Articles

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

Flora J. Logan, Martin C. Taylor, Shane R. Wilkinson, Harparkash Kaur, John M. Kelly

Biochem J (2007) 407 (3): 419–426.

https://doi.org/10.1042/BJ20070766

Published: 12 October 2007

View article titled, The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

Includes: Supplementary data

Articles

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi : cytoprotective action of mitochondrial iron superoxide dismutase overexpression

Lucía Piacenza, Florencia Irigoín, María Noel Alvarez, Gonzalo Peluffo, Martin C. Taylor, John M. Kelly, Shane R. Wilkinson, Rafael Radi

Biochem J (2007) 403 (2): 323–334.

https://doi.org/10.1042/BJ20061281

Published: 26 March 2007

View article titled, Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi : cytoprotective action of mitochondrial iron superoxide dismutase overexpression

Includes: Supplementary data

Articles

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Christine C. MILBURN, Maria DEAK, Sharon M. KELLY, Nick C. PRICE, Dario R. ALESSI, Daan M. F. van AALTEN

Biochem J (2003) 375 (3): 531–538.

https://doi.org/10.1042/bj20031229

Published: 01 November 2003

View article titled, Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Articles

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

Shane R. WILKINSON, Martin C. TAYLOR, Said TOUITHA, Isabel L. MAURICIO, David J. MEYER, John M. KELLY

Biochem J (2002) 364 (3): 787–794.

https://doi.org/10.1042/bj20020038

Published: 15 June 2002

View article titled, TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

Articles

Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity

Shane R. WILKINSON, David J. MEYER, John M. KELLY

Biochem J (2000) 352 (3): 755–761.

https://doi.org/10.1042/bj3520755

Published: 08 December 2000

View article titled, Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity

Articles

Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase

Claire LEADBEATER, Lisa MCIVER, Dominic J. CAMPOPIANO, Scott P. WEBSTER, Robert L. BAXTER, Sharon M. KELLY, Nicholas C. PRICE, Dominikus A. LYSEK, Michael A. NOBLE, Stephen K. CHAPMAN, Andrew W. MUNRO

Biochem J (2000) 352 (2): 257–266.

https://doi.org/10.1042/bj3520257

Published: 24 November 2000

View article titled, Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase

Articles

Central modules of the vaccinia virus complement control protein are not in extensive contact

Marina D. KIRKITADZE, Colin HENDERSON, Nicholas C. PRICE, Sharon M. KELLY, Nicholas P. MULLIN, John PARKINSON, David T. F. DRYDEN, Paul N. BARLOW

Biochem J (1999) 344 (1): 167–175.

https://doi.org/10.1042/bj3440167

Published: 08 November 1999

View article titled, Central modules of the vaccinia virus complement control protein are not in extensive contact

Articles

Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments

Joyce MOORE, Lindsay McDERMOTT, Nicholas C. PRICE, Sharon M. KELLY, Alan COOPER, Malcolm W. KENNEDY

Biochem J (1999) 340 (1): 337–343.

https://doi.org/10.1042/bj3400337

Published: 10 May 1999

View article titled, Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments

Articles

The folding and assembly of the dodecameric type II dehydroquinases

Nicholas C. PRICE, Deborah J. BOAM, Sharon M. KELLY, Doris DUNCAN, Tino KRELL, David G. GOURLEY, John R. COGGINS, Richard VIRDEN, Alastair R. HAWKINS

Biochem J (1999) 338 (1): 195–202.

https://doi.org/10.1042/bj3380195

Published: 08 February 1999

View article titled, The folding and assembly of the dodecameric type II dehydroquinases

Articles

The role of the C-terminal region in phosphoglycerate mutase

Rebecca A. WALTER, Jacqueline NAIRN, Doris DUNCAN, Nicholas C. PRICE, Sharon M. KELLY, Daniel J. RIGDEN, Linda A. FOTHERGILL-GILMORE

Biochem J (1999) 337 (1): 89–95.

https://doi.org/10.1042/bj3370089

Published: 17 December 1998

View article titled, The role of the C-terminal region in phosphoglycerate mutase

Articles

Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids

Steven G. LOVE, Tom W. MUIR, Robert RAMAGE, Kevin T. SHAW, Dmitriy ALEXEEV, Lindsay SAWYER, Sharon M. KELLY, Nicholas C. PRICE, Jane E. ARNOLD, Maureen P. MEE, R. John MAYER

Biochem J (1997) 323 (3): 727–734.

https://doi.org/10.1042/bj3230727

Published: 01 May 1997

View article titled, Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids

Articles

Dissociation and unfolding of the pyruvate dehydrogenase complex by guanidinium chloride

S M West, J E Rice, E S Beaumont, S M Kelly, N C Price, J G Lindsay

Biochem J (1995) 308 (3): 1025–1029.

https://doi.org/10.1042/bj3081025

Published: 15 June 1995

View article titled, Dissociation and unfolding of the pyruvate dehydrogenase complex by guanidinium chloride

Articles

Probing the details of the HIV-1 Rev-Rev-responsive element interaction: effects of modified nucleotides on protein affinity and conformational changes during complex formation

S B Renwick, A D Critchley, C J Adams, S M Kelly, N C Price, P G Stockley

Biochem J (1995) 308 (2): 447–453.

https://doi.org/10.1042/bj3080447

Published: 01 June 1995

View article titled, Probing the details of the HIV-1 Rev-Rev-responsive element interaction: effects of modified nucleotides on protein affinity and conformational changes during complex formation

Articles

The role of tryptophan 97 of cytochrome P 450 BM3 from Bacillus megaterium in catalytic function. Evidence against the ‘covalent switching’ hypothesis of P -450 electron transfer

A W Munro, K Malarkey, J McKnight, A J Thomson, S M Kelly, N C Price, J G Lindsay, J R Coggins, J S Miles

Biochem J (1994) 303 (2): 423–428.

https://doi.org/10.1042/bj3030423

Published: 15 October 1994

View article titled, The role of tryptophan 97 of cytochrome P 450 BM3 from Bacillus megaterium in catalytic function. Evidence against the ‘covalent switching’ hypothesis of P -450 electron transfer

Articles

Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region

M F White, L A Fothergill-Gilmore, S M Kelly, N C Price

Biochem J (1993) 295 (3): 743–748.

https://doi.org/10.1042/bj2950743

Published: 01 November 1993

View article titled, Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region

Articles

Characterization of the type I dehydroquinase from Salmonella typhi

J D Moore, A R Hawkins, I G Charles, R Deka, J R Coggins, A Cooper, S M Kelly, N C Price

Biochem J (1993) 295 (1): 277–285.

https://doi.org/10.1042/bj2950277

Published: 01 October 1993

View article titled, Characterization of the type I dehydroquinase from Salmonella typhi

Articles

Substitution of His-181 by alanine in yeast phosphoglycerate mutase leads to cofactor-induced dissociation of the tetrameric structure

M F White, L A Fothergill-Gilmore, S M Kelly, N C Price

Biochem J (1993) 291 (2): 479–483.

https://doi.org/10.1042/bj2910479

Published: 15 April 1993

View article titled, Substitution of His-181 by alanine in yeast phosphoglycerate mutase leads to cofactor-induced dissociation of the tetrameric structure

Articles

On the role of the C-terminus of α -calcitonin-gene-related peptide ( α CGRP). The structure of des-phenylalaninamide 37 - α CGRP and its interaction with the CGRP receptor

J P O'Connell, S M Kelly, D P Raleigh, J A M Hubbard, N C Price, C M Dobson, B J Smith

Biochem J (1993) 291 (1): 205–210.

https://doi.org/10.1042/bj2910205

Published: 01 April 1993

View article titled, On the role of the C-terminus of α -calcitonin-gene-related peptide ( α CGRP). The structure of des-phenylalaninamide 37 - α CGRP and its interaction with the CGRP receptor

Articles

Transglutaminase catalyses the modification of glutamine side chains in the C -terminal region of bovine β -lactoglobulin

P J Coussons, N C Price, S M Kelly, B Smith, L Sawyer

Biochem J (1992) 283 (3): 803–806.

https://doi.org/10.1042/bj2830803

Published: 01 May 1992

View article titled, Transglutaminase catalyses the modification of glutamine side chains in the C -terminal region of bovine β -lactoglobulin

Articles

A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes

C Kleanthous, R Deka, K Davis, S M Kelly, A Cooper, S E Harding, N C Price, A R Hawkins, J R Coggins

Biochem J (1992) 282 (3): 687–695.

https://doi.org/10.1042/bj2820687

Published: 15 March 1992

View article titled, A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes

Articles

Factors that govern the specificity of transglutaminase-catalysed modification of proteins and peptides

P J Coussons, N C Price, S M Kelly, B Smith, L Sawyer

Biochem J (1992) 282 (3): 929–930.

https://doi.org/10.1042/bj2820929

Published: 15 March 1992

View article titled, Factors that govern the specificity of transglutaminase-catalysed modification of proteins and peptides

Articles

Structural properties of long- and short-chain alcohol dehydrogenases. Contribution of NAD + to stability

L Ribas De Pouplana, S Atrian, R Gonzàlex-Duarte, L A Fothergill-Gilmore, S M Kelly, N C Price

Biochem J (1991) 276 (2): 433–438.

https://doi.org/10.1042/bj2760433

Published: 01 June 1991

View article titled, Structural properties of long- and short-chain alcohol dehydrogenases. Contribution of NAD + to stability

Articles

The unfolding and refolding of pig heart fumarase

S M Kelly, N C Price

Biochem J (1991) 275 (3): 745–749.

https://doi.org/10.1042/bj2750745

Published: 01 May 1991

View article titled, The unfolding and refolding of pig heart fumarase

Articles

Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin

J A M Hubbard, S R Martin, L C Chaplin, C Bose, S M Kelly, N C Price

Biochem J (1991) 275 (3): 785–788.

https://doi.org/10.1042/bj2750785

Published: 01 May 1991

View article titled, Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin

Articles

Selective modification by transglutaminase of a glutamine side chain in the hinge region of the histidine-388→glutamine mutant of yeast phosphoglycerate kinase

P J Coussons, S M Kelly, N C Price, C M Johnson, B Smith, L Sawyer

Biochem J (1991) 273 (1): 73–78.

https://doi.org/10.1042/bj2730073

Published: 01 January 1991

View article titled, Selective modification by transglutaminase of a glutamine side chain in the hinge region of the histidine-388→glutamine mutant of yeast phosphoglycerate kinase

Articles

Long-term dosing studies using mutagenic carcinogens indicate a highly significant correlation between elevations in the level of rat glutathione S -transferase P messenger RNA and liver tumours of hepatocellular origin

S E H Russell, C Pearson, M Kelly, S McQuaid, P Humphries

Biochem J (1988) 249 (1): 105–109.

https://doi.org/10.1042/bj2490105

Published: 01 January 1988

View article titled, Long-term dosing studies using mutagenic carcinogens indicate a highly significant correlation between elevations in the level of rat glutathione S -transferase P messenger RNA and liver tumours of hepatocellular origin

Articles

Evidence on the conformation of HeLa-cell 5.8S ribosomal ribonucleic acid from the reaction of specific cytidine residues with sodium bisulphite

J M Kelly, J P Goddard, B E H Maden

Biochem J (1978) 173 (2): 521–532.

https://doi.org/10.1042/bj1730521

Published: 01 August 1978

View article titled, Evidence on the conformation of HeLa-cell 5.8S ribosomal ribonucleic acid from the reaction of specific cytidine residues with sodium bisulphite

Articles

Hydrogen-deuterium exchange reactions catalysed by nitrogenase

M Kelly

Biochem J (1968) 109 (2): 322–324.

https://doi.org/10.1042/bj1090322

Published: 01 September 1968

View article titled, Hydrogen-deuterium exchange reactions catalysed by nitrogenase

Articles

The kinetics of the reduction of isocyanides, acetylenes and the cyanide ion by nitrogenase preparation from Azotobacter chroococcum and the effects of inhibitors

M Kelly

Biochem J (1968) 107 (1): 1–6.

https://doi.org/10.1042/bj1070001

Published: 01 March 1968

View article titled, The kinetics of the reduction of isocyanides, acetylenes and the cyanide ion by nitrogenase preparation from Azotobacter chroococcum and the effects of inhibitors

Articles

Fractionation and storage of nitrogenase from Azotobacter vinelandii

M Kelly, R V Klucas, R H Burris

Biochem J (1967) 105 (1): 3C–5C.

https://doi.org/10.1042/bj1050003C

Published: 01 October 1967

View article titled, Fractionation and storage of nitrogenase from Azotobacter vinelandii

Articles

Reduction of Cyanide and Isocyanide by Nitrogenase of Azotobacter chroococcum

M. Kelly, J. R. Postgate, R. L. Richards

Biochem J (1967) 102 (1): 1C–3C.

https://doi.org/10.1042/bj1020001C

Published: 01 January 1967

View article titled, Reduction of Cyanide and Isocyanide by Nitrogenase of Azotobacter chroococcum

Articles

Purification and properties of acyltransferases from Pseudomonas aeruginosa

M Kelly, HL Kornberg

Biochem J (1964) 93 (3): 557–566.

https://doi.org/10.1042/bj0930557

Published: 01 December 1964

View article titled, Purification and properties of acyltransferases from Pseudomonas aeruginosa

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