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Articles

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

Open Access
Tess R. Malcolm, Karolina W. Swiderska, Brooke K. Hayes, Chaille T. Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan
Journal: Biochemical Journal
Biochem J (2021) 478 (13): 2697–2713.
https://doi.org/10.1042/BCJ20210172
Published: 16 July 2021
View articletitled, Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
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Includes: Supplementary data
Articles

Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7

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Izabela Maluch, Justyna Grzymska, Scott J. Snipas, Guy S. Salvesen, Marcin Drag
Journal: Biochemical Journal
Biochem J (2021) 478 (12): 2233–2245.
https://doi.org/10.1042/BCJ20210255
Published: 18 June 2021
View articletitled, Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7
Open the PDF for Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7 in another window
Includes: Supplementary data
Articles

X-ray crystal structure and specificity of the Toxoplasma gondii ME49 Tg APN2

Open Access
Emilia M. Marijanovic, Karolina Weronika Swiderska, James Andersen, Jasmin C. Aschenbrenner, Chaille T. Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan
Journal: Biochemical Journal
Biochem J (2020) 477 (19): 3819–3832.
https://doi.org/10.1042/BCJ20200569
Published: 12 October 2020
View articletitled, X-ray crystal structure and specificity of the Toxoplasma gondii ME49 Tg APN2
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Includes: Supplementary data
Articles

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Available to Purchase
Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S. Bamert, Wioletta Rut, Khadija Mohamed, Natalie B. Vinh, Peter J. Scammells, Marcin Drag, Sheena McGowan
Journal: Biochemical Journal
Biochem J (2016) 473 (19): 3189–3204.
https://doi.org/10.1042/BCJ20160550
Published: 27 September 2016
View articletitled, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum
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Includes: Supplementary data
Articles

SARS hCoV papain-like protease is a unique Lys 48 linkage-specific di-distributive deubiquitinating enzyme

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In Collection
Coronavirus
Miklós Békés, Wioletta Rut, Paulina Kasperkiewicz, Monique P.C. Mulder, Huib Ovaa, Marcin Drag, Christopher D. Lima, Tony T. Huang
Journal: Biochemical Journal
Biochem J (2015) 468 (2): 215–226.
https://doi.org/10.1042/BJ20141170
Published: 22 May 2015
View articletitled, SARS hCoV papain-like protease is a unique Lys 48 linkage-specific di-distributive deubiquitinating enzyme
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Includes: Supplementary data
Articles

Mechanism and specificity of the human paracaspase MALT1

Open Access
Janna Hachmann, Scott J. Snipas, Bram J. van Raam, Erik M. Cancino, Emily J. Houlihan, Marcin Poreba, Paulina Kasperkiewicz, Marcin Drag, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2012) 443 (1): 287–295.
https://doi.org/10.1042/BJ20120035
Published: 14 March 2012
View articletitled, Mechanism and specificity of the human paracaspase MALT1
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Articles

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

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Efthalia Zervoudi, Athanasios Papakyriakou, Dimitra Georgiadou, Irini Evnouchidou, Anna Gajda, Marcin Poreba, Guy S. Salvesen, Marcin Drag, Akira Hattori, Luc Swevers, Dionisios Vourloumis, Efstratios Stratikos
Journal: Biochemical Journal
Biochem J (2011) 435 (2): 411–420.
https://doi.org/10.1042/BJ20102049
Published: 29 March 2011
View articletitled, Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
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Includes: Supplementary data
Articles

FLIP L induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

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Cristina Pop, Andrew Oberst, Marcin Drag, Bram J. Van Raam, Stefan J. Riedl, Douglas R. Green, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2011) 433 (3): 447–457.
https://doi.org/10.1042/BJ20101738
Published: 14 January 2011
View articletitled, FLIP L induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
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Includes: Supplementary data
Articles

Distribution and paralogue specificity of mammalian deSUMOylating enzymes

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Nagamalleswari Kolli, Jowita Mikolajczyk, Marcin Drag, Debaditya Mukhopadhyay, Nela Moffatt, Mary Dasso, Guy Salvesen, Keith D. Wilkinson
Journal: Biochemical Journal
Biochem J (2010) 430 (2): 335–344.
https://doi.org/10.1042/BJ20100504
Published: 13 August 2010
View articletitled, Distribution and paralogue specificity of mammalian deSUMOylating enzymes
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Includes: Supplementary data
Articles

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

Open Access
Jad Walters, Cristina Pop, Fiona L. Scott, Marcin Drag, Paul Swartz, Carla Mattos, Guy S. Salvesen, A. Clay Clark
Journal: Biochemical Journal
Biochem J (2009) 424 (3): 335–345.
https://doi.org/10.1042/BJ20090825
Published: 10 December 2009
View articletitled, A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
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Includes: Multimedia, Supplementary data
Articles

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)

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Marcin Drag, Jowita Mikolajczyk, Miklos Bekes, Francisca E. Reyes-Turcu, Jonathan A. Ellman, Keith D. Wilkinson, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2008) 415 (3): 367–375.
https://doi.org/10.1042/BJ20080779
Published: 15 October 2008
View articletitled, Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
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Articles

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

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Marcin Drag, Jowita Mikolajczyk, I. M. Krishnakumar, Ziwei Huang, Guy S. Salvesen
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 461–469.
https://doi.org/10.1042/BJ20070940
Published: 21 December 2007
View articletitled, Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
Open the PDF for Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family in another window
Includes: Supplementary data