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Michael J. Davies
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Articles

Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Rebecca H. J. Bloemen, Rafael Radi, Michael J. Davies, Eduardo Fuentes-Lemus
Journal: Biochemical Journal
Biochem J (2024) 481 (23): 1855–1866.
https://doi.org/10.1042/BCJ20240597
Published: 04 December 2024
View article titled, Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase
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Includes: Supplementary data
Articles

Protein oxidation and peroxidation

Michael J. Davies
Journal: Biochemical Journal
Biochem J (2016) 473 (7): 805–825.
https://doi.org/10.1042/BJ20151227
Published: 29 March 2016
View article titled, Protein oxidation and peroxidation
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Articles

Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells

Christine Y. Chuang, Georg Degendorfer, Astrid Hammer, John M. Whitelock, Ernst Malle, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2014) 459 (2): 313–322.
https://doi.org/10.1042/BJ20131471
Published: 28 March 2014
View article titled, Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells
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Includes: Supplementary data
Articles

The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction

Jihan Talib, Jair Kwan, Aldwin Suryo Rahmanto, Paul K. Witting, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2014) 457 (1): 89–97.
https://doi.org/10.1042/BJ20131135
Published: 10 December 2013
View article titled, The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction
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Articles

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

Katrina A. Hadfield, David I. Pattison, Bronwyn E. Brown, Liming Hou, Kerry-Anne Rye, Michael J. Davies, Clare L. Hawkins
Journal: Biochemical Journal
Biochem J (2013) 449 (2): 531–542.
https://doi.org/10.1042/BJ20121210
Published: 14 December 2012
View article titled, Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
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Includes: Supplementary data
Articles

Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

Ojia Skaff, David I. Pattison, Philip E. Morgan, Rushad Bachana, Vimal K. Jain, K. Indira Priyadarsini, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2012) 441 (1): 305–316.
https://doi.org/10.1042/BJ20101762
Published: 14 December 2011
View article titled, Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
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Articles

Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3

Alexander V. Peskin, Andrew G. Cox, Péter Nagy, Philip E. Morgan, Mark B. Hampton, Michael J. Davies, Christine C. Winterbourn
Journal: Biochemical Journal
Biochem J (2010) 432 (2): 313–321.
https://doi.org/10.1042/BJ20101156
Published: 12 November 2010
View article titled, Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3
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Includes: Supplementary data
Articles

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

Amanda E. Lane, Joanne T. M. Tan, Clare L. Hawkins, Alison K. Heather, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2010) 430 (1): 161–169.
https://doi.org/10.1042/BJ20100082
Published: 28 July 2010
View article titled, The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
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Articles

Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

Ojia Skaff, David I. Pattison, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2009) 422 (1): 111–117.
https://doi.org/10.1042/BJ20090276
Published: 29 July 2009
View article titled, Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance
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Articles

Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

Martin D. Rees, Steven E. Bottle, Kathryn E. Fairfull-Smith, Ernst Malle, John M. Whitelock, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2009) 421 (1): 79–86.
https://doi.org/10.1042/BJ20090309
Published: 12 June 2009
View article titled, Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides
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Includes: Supplementary data
Articles

Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

Anna L. P. Chapman, Ojia Skaff, Revathy Senthilmohan, Anthony J. Kettle, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2009) 417 (3): 773–781.
https://doi.org/10.1042/BJ20071563
Published: 16 January 2009
View article titled, Hypobromous acid and bromamine production by neutrophils and modulation by superoxide
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Includes: Supplementary data
Articles

Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

Clare L. Hawkins, David I. Pattison, Naomi R. Stanley, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2008) 416 (3): 441–452.
https://doi.org/10.1042/BJ20070941
Published: 26 November 2008
View article titled, Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation
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Articles

Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

Mitchell M. Lloyd, David M. van Reyk, Michael J. Davies, Clare L. Hawkins
Journal: Biochemical Journal
Biochem J (2008) 414 (2): 271–280.
https://doi.org/10.1042/BJ20080468
Published: 12 August 2008
View article titled, Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
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Articles

Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links

Marianne N. Lund, Catherine Luxford, Leif H. Skibsted, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2008) 410 (3): 565–574.
https://doi.org/10.1042/BJ20071107
Published: 27 February 2008
View article titled, Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links
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Articles

Degradation of extracellular matrix and its components by hypobromous acid

Martin D. Rees, Tane N. McNiven, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2007) 401 (2): 587–596.
https://doi.org/10.1042/BJ20061236
Published: 21 December 2006
View article titled, Degradation of extracellular matrix and its components by hypobromous acid
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Articles

Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols

Jingmin Zeng, Rachael A. Dunlop, Kenneth J. Rodgers, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2006) 398 (2): 197–206.
https://doi.org/10.1042/BJ20060019
Published: 15 August 2006
View article titled, Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols
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Articles

Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation

Martin D. Rees, David I. Pattison, Michael J. Davies
Journal: Biochemical Journal
Biochem J (2005) 391 (1): 125–134.
https://doi.org/10.1042/BJ20050630
Published: 26 September 2005
View article titled, Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation
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Includes: Supplementary data
Articles

Guanine-specific DNA damage induced by γ-irradiated histone

Ayako FURUKAWA, Yusuke HIRAKU, Shinji OIKAWA, Catherine LUXFORD, Michael J. DAVIES, Shosuke KAWANISHI
Journal: Biochemical Journal
Biochem J (2005) 388 (3): 813–818.
https://doi.org/10.1042/BJ20050186
Published: 07 June 2005
View article titled, Guanine-specific DNA damage induced by γ-irradiated histone
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Articles

Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

Martin D. REES, Clare L. HAWKINS, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (2004) 381 (1): 175–184.
https://doi.org/10.1042/BJ20040148
Published: 22 June 2004
View article titled, Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates
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Articles

Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides

Christine C. WINTERBOURN, Helena N. PARSONS-MAIR, Silvia GEBICKI, Janusz M. GEBICKI, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (2004) 381 (1): 241–248.
https://doi.org/10.1042/BJ20040259
Published: 22 June 2004
View article titled, Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides
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Articles

Fragmentation of extracellular matrix by hypochlorous acid

Alan A. WOODS, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (2003) 376 (1): 219–227.
https://doi.org/10.1042/bj20030715
Published: 15 November 2003
View article titled, Fragmentation of extracellular matrix by hypochlorous acid
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Articles

Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques

Alan A. WOODS, Stuart M. LINTON, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (2003) 370 (2): 729–735.
https://doi.org/10.1042/bj20021710
Published: 01 March 2003
View article titled, Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques
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Articles

Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein–DNA cross-links and DNA fragmentation

Clare L. HAWKINS, David I. PATTISON, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (2002) 365 (3): 605–615.
https://doi.org/10.1042/bj20020363
Published: 01 August 2002
View article titled, Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein–DNA cross-links and DNA fragmentation
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Articles

Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen

David M. SHAW, Andrew M. WOODS, Kevin A. MYERS, Caroline WESTWATER, Veena RAHI-SAUND, Michael J. DAVIES, David V. RENOUF, Elizabeth F. HOUNSELL, Peter L. STERN
Journal: Biochemical Journal
Biochem J (2002) 363 (1): 137–145.
https://doi.org/10.1042/bj3630137
Published: 22 March 2002
View article titled, Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen
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Articles

Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA

Catherine LUXFORD, Benedicte MORIN, Roger T. DEAN, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (1999) 344 (1): 125–134.
https://doi.org/10.1042/bj3440125
Published: 08 November 1999
View article titled, Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA
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Articles

Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

Clare L. HAWKINS, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (1999) 340 (2): 539–548.
https://doi.org/10.1042/bj3400539
Published: 25 May 1999
View article titled, Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation
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Articles

Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins

Linda J. HAZELL, Michael J. DAVIES, Roland STOCKER
Journal: Biochemical Journal
Biochem J (1999) 339 (3): 489–495.
https://doi.org/10.1042/bj3390489
Published: 26 April 1999
View article titled, Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins
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Articles

Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque

Shanlin FU, Michael J. DAVIES, Roland STOCKER, Roger T. DEAN
Journal: Biochemical Journal
Biochem J (1998) 333 (3): 519–525.
https://doi.org/10.1042/bj3330519
Published: 01 August 1998
View article titled, Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque
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Articles

Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation

Clare L. HAWKINS, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (1998) 332 (3): 617–625.
https://doi.org/10.1042/bj3320617
Published: 15 June 1998
View article titled, Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation
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Articles

Biochemistry and pathology of radical-mediated protein oxidation

Roger T. DEAN, Shanlin FU, Roland STOCKER, Michael J. DAVIES
Journal: Biochemical Journal
Biochem J (1997) 324 (1): 1–18.
https://doi.org/10.1042/bj3240001
Published: 15 May 1997
View article titled, Biochemistry and pathology of radical-mediated protein oxidation
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