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Muthusamy Thangaraju
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Articles

Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice

Open Access
Kevin Bass, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Muthusamy Thangaraju, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2024) 481 (4): 295–312.
https://doi.org/10.1042/BCJ20230403
Published: 19 February 2024
View articletitled, Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice
Open the PDF for Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice in another window
Includes: Supplementary data
Articles

Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis

Open Access
Sabarish Ramachandran, Souad R. Sennoune, Monica Sharma, Muthusamy Thangaraju, Varshini V. Suresh, Tyler Sneigowski, Yangzom D. Bhutia, Kevin Pruitt, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2021) 478 (21): 3957–3976.
https://doi.org/10.1042/BCJ20210585
Published: 12 November 2021
View articletitled, Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis
Open the PDF for Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis in another window
Includes: Supplementary data
Articles

SLC6A14, a Na + /Cl − -coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

Open Access
Mohd O. F. Sikder, Sathish Sivaprakasam, Timothy P. Brown, Muthusamy Thangaraju, Yangzom D. Bhutia, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2020) 477 (8): 1409–1425.
https://doi.org/10.1042/BCJ20200099
Published: 23 April 2020
View articletitled, SLC6A14, a Na + /Cl − -coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling
Open the PDF for SLC6A14, a Na + /Cl − -coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling in another window
Includes: Supplementary data
Articles

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

Available to Purchase
Yangzom D. Bhutia, Ellappan Babu, Sabarish Ramachandran, Shengping Yang, Muthusamy Thangaraju, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2016) 473 (9): 1113–1124.
https://doi.org/10.1042/BJ20150751
Published: 26 April 2016
View articletitled, SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms
Open the PDF for SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms in another window
Articles

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

Available to Purchase
Ellappan Babu, Yangzom D. Bhutia, Sabarish Ramachandran, Jaya P. Gnanaprakasam, Puttur D. Prasad, Muthusamy Thangaraju, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2015) 469 (1): 17–23.
https://doi.org/10.1042/BJ20150437
Published: 19 June 2015
View articletitled, Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer
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Articles

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function

Available to Purchase
Veena Coothankandaswamy, Selvakumar Elangovan, Nagendra Singh, Puttur D. Prasad, Muthusamy Thangaraju, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2013) 450 (1): 169–178.
https://doi.org/10.1042/BJ20121248
Published: 24 January 2013
View articletitled, The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function
Open the PDF for The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function in another window
Includes: Supplementary data
Articles

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger

Available to Purchase
Jaya P. Gnana-Prakasam, Muthusamy Thangaraju, Kebin Liu, Yonju Ha, Pamela M. Martin, Sylvia B. Smith, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2009) 424 (2): 243–252.
https://doi.org/10.1042/BJ20090424
Published: 11 November 2009
View articletitled, Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger
Open the PDF for Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger in another window
Includes: Supplementary data
Articles

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

Available to Purchase
Muthusamy Thangaraju, Kristina N. Carswell, Puttur D. Prasad, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2009) 417 (1): 379–389.
https://doi.org/10.1042/BJ20081132
Published: 12 December 2008
View articletitled, Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3
Open the PDF for Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3 in another window
Articles

Interaction of tryptophan derivatives with SLC6A14 (ATB 0,+ ) reveals the potential of the transporter as a drug target for cancer chemotherapy

Available to Purchase
Senthil Karunakaran, Nagavedi S. Umapathy, Muthusamy Thangaraju, Takahiro Hatanaka, Shiro Itagaki, David H. Munn, Puttur D. Prasad, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2008) 414 (3): 343–355.
https://doi.org/10.1042/BJ20080622
Published: 27 August 2008
View articletitled, Interaction of tryptophan derivatives with SLC6A14 (ATB 0,+ ) reveals the potential of the transporter as a drug target for cancer chemotherapy
Open the PDF for Interaction of tryptophan derivatives with SLC6A14 (ATB 0,+ ) reveals the potential of the transporter as a drug target for cancer chemotherapy in another window