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Natalia Shpiro
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Articles

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Open Access
Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen
Journal: Biochemical Journal
Biochem J (2022) 479 (20): 2195–2216.
https://doi.org/10.1042/BCJ20220401
Published: 21 October 2022
View articletitled, Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
Open the PDF for Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC in another window
Includes: Supplementary data
Articles

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Open Access
Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2016) 473 (17): 2671–2685.
https://doi.org/10.1042/BCJ20160557
Published: 30 August 2016
View articletitled, Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Open the PDF for Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors in another window
Includes: Supplementary data
Articles

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Open Access
Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2014) 463 (3): 413–427.
https://doi.org/10.1042/BJ20140889
Published: 10 October 2014
View articletitled, Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
Open the PDF for Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase in another window
Includes: Supplementary data
Articles

Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Open Access
Vanessa P. Houde, Maria Stella Ritorto, Robert Gourlay, Joby Varghese, Paul Davies, Natalia Shpiro, Kei Sakamoto, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2014) 458 (1): 41–56.
https://doi.org/10.1042/BJ20131324
Published: 20 January 2014
View articletitled, Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
Open the PDF for Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity in another window
Includes: Supplementary data
Articles

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Open Access
Sam Strickson, David G. Campbell, Christoph H. Emmerich, Axel Knebel, Lorna Plater, Maria Stella Ritorto, Natalia Shpiro, Philip Cohen
Journal: Biochemical Journal
Biochem J (2013) 451 (3): 427–437.
https://doi.org/10.1042/BJ20121651
Published: 12 April 2013
View articletitled, The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system
Open the PDF for The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system in another window
Includes: Supplementary data
Articles

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors

Available to Purchase
Ayaz Najafov, Natalia Shpiro, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2012) 448 (2): 285–295.
https://doi.org/10.1042/BJ20121287
Published: 07 November 2012
View articletitled, Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors
Open the PDF for Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors in another window
Includes: Supplementary data
Articles

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

Open Access
Roland Hjerpe, Yann Thomas, Jesse Chen, Aleksandra Zemla, Siobhan Curran, Natalia Shpiro, Lawrence R. Dick, Thimo Kurz
Journal: Biochemical Journal
Biochem J (2012) 441 (3): 927–939.
https://doi.org/10.1042/BJ20111671
Published: 16 January 2012
View articletitled, Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
Open the PDF for Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes in another window
Includes: Supplementary data
Articles

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Available to Purchase
Xu Huang, Stephan Wullschleger, Natalia Shpiro, Victoria A. McGuire, Kei Sakamoto, Yvonne L. Woods, Wendy Mcburnie, Stewart Fleming, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2008) 412 (2): 211–221.
https://doi.org/10.1042/BJ20080557
Published: 14 May 2008
View articletitled, Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
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Includes: Supplementary data
Articles

The selectivity of protein kinase inhibitors: a further update

Available to Purchase
Jenny Bain, Lorna Plater, Matt Elliott, Natalia Shpiro, C. James Hastie, Hilary Mclauchlan, Iva Klevernic, J. Simon C. Arthur, Dario R. Alessi, Philip Cohen
Journal: Biochemical Journal
Biochem J (2007) 408 (3): 297–315.
https://doi.org/10.1042/BJ20070797
Published: 28 November 2007
View articletitled, The selectivity of protein kinase inhibitors: a further update
Open the PDF for The selectivity of protein kinase inhibitors: a further update in another window
Includes: Supplementary data
Articles

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

Available to Purchase
James T. MURRAY, David G. CAMPBELL, Nicholas MORRICE, Gillian C. AULD, Natalia SHPIRO, Rodolpho MARQUEZ, Mark PEGGIE, Jenny BAIN, Graham B. BLOOMBERG, Florian GRAHAMMER, Florian LANG, Peer WULFF, Dietmar KUHL, Philip COHEN
Journal: Biochemical Journal
Biochem J (2004) 384 (3): 477–488.
https://doi.org/10.1042/BJ20041057
Published: 07 December 2004
View articletitled, Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3
Open the PDF for Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 in another window